NIDCD R21/R33 Phased Infrastructure Grant for Patient-Oriented Research

NIDCD R21/R33 针对以患者为导向的研究的分阶段基础设施拨款

• 批准号: 7599120
• 负责人: DAVID L WITSELL
• 金额: $ 57.21万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7599120
• 关键词: Academic Medical Centers; Address; Ally; Businesses; Bylaw; Characteristics; Classification; Clinical; Clinical Research; Collaborations; Commit; Communication; Communication impairment; Communities; Conflict of Interest; Data; Databases; Development; Diagnostic; Disease; Education; Effectiveness; Elements; Environment; Equipment and supply inventories; Evaluation; Foundations; Funding; Goals; Grant; Health Professional; Healthcare; Hearing; Home environment; Information Technology; Institution; Internet; Learning; Level of Evidence; Manuscripts; Mission; Modeling; Monitor; National Institute on Deafness and Other Communication Disorders; Online Systems; Operations Research; Otolaryngologist; Otolaryngology; Participant; Patient Recruitments; Patients; Phase; Physicians; Policies; Primary Health Care; Publications; Recommendation; Research; Research Ethics; Research Infrastructure; Research Institute; Research Methodology; Research Personnel; Resources; Role; Science; Site; Specialist; Strategic Planning; Structure; System; Testing; Therapeutic Intervention; Time; Training; Training and Education; Translational Research; United States National Institutes of Health; Vision; Work; Writing; base; beneficiary; clinical practice; community based practice; cost; data acquisition; design; empowered; equilibration disorder; experience; human subject; implementation research; innovation; interdisciplinary collaboration; interest; interoperability; medical specialties; member; novel strategies; organizational structure; patient oriented; patient oriented research; practice-based research network; programs; success; tool

DESCRIPTION (provided by applicant): The OBJECTIVE of the plan outlined for the next five years is to plan, develop, and put into place the infrastructure elements that will result in a more efficient, patient-oriented research network that phases out the existing disconnect between discovery and implementation, research and practice. It is our CENTRAL HYPOTHESIS that a network organized and focused on regional dynamic research alliances will have increased appeal to community-based health care professionals and patients, resulting in enhanced communications, interoperability, and success in the conduct of multi-center clinical research. In PHASE 1 (R21) of this project, we will establish the foundation for development of an effective and successful research administrative infrastructure at the Duke Clinical Research Institute (DCRI) that can operate at the center of an integrated, multi-institutional, nationwide network to support clinical and translational research in hearing and balance disorders. Our network, called CHEER, Creating Healthcare Excellence through Education and Research, will be a dynamic alliance of central coordination with regional academic partners and community-based health care professional. The community otolaryngologist and his/her ancillary health care professionals will be an integral part of the CHEER network. Our SPECIFIC AIMS include: 1. Collect comprehensive information on relevant research programs from our co-investigators and their corresponding institution, consultants, and other organizations engaged in multi-center patient- oriented research, 2. Collect comprehensive information from established practice-based research networks in otolaryngology, networks funded by NIH Roadmap initiatives, and selected networks included in the Inventory and Evaluation of Clinical Research Networks (IECRN) database, and 3. Finalize and submit for publication strategic and business plans for building the central research network administrative infrastructure for hearing and balance disorders, based at the DCRI. In PHASE 2 (R33), we will utilize the groundwork and strategic plan developed in PHASE 1 of the project to guide the systematic, stepwise implementation of systems, and educational programs using a multifunctional information technology platform. This platform, called Research about Research (RaR), is easily adaptable, HIPPA compliant and supports the use of common data standards. We will utilize the experience of the DCRI, PI and our co-investigators to adapt RaR to support effective communications among regional and community-based collaborators, development of central and regional research administration, and implementation of educational programs to operationalize the CHEER network.

描述（由申请人提供）：未来五年计划的目标是规划、开发和落实基础设施要素，从而形成更高效、以患者为导向的研究网络，逐步消除现有的脱节发现与实施、研究与实践之间。我们的中心假设是，一个组织并专注于区域动态研究联盟的网络将增加对社区医疗保健专业人员和患者的吸引力，从而增强沟通、互操作性并促进多中心临床研究的成功。在该项目的第一阶段 (R21)，我们将为杜克临床研究所 (DCRI) 建立有效且成功的研究管理基础设施的发展奠定基础，该基础设施可以在综合、多机构、全国网络的中心运行支持听力和平衡障碍的临床和转化研究。我们的网络名为 CHEER（通过教育和研究创造卓越医疗保健），将成为与区域学术合作伙伴和社区医疗保健专业人员进行中央协调的动态联盟。社区耳鼻喉科医生及其辅助医疗保健专业人员将成为 CHEER 网络不可或缺的一部分。我们的具体目标包括： 1. 从我们的共同研究者及其相应机构、顾问和其他从事以患者为中心的多中心研究的组织收集相关研究项目的综合信息， 2. 从已建立的基于实践的研究中收集综合信息耳鼻喉科网络、NIH 路线图计划资助的网络以及临床研究网络清单和评估 (IECRN) 数据库中包含的选定网络，以及 3. 最终确定并提交出版战略和业务计划以 DCRI 为基础，建设听力和平衡障碍的中央研究网络管理基础设施。在第二阶段（R33）中，我们将利用项目第一阶段制定的基础工作和战略计划，利用多功能信息技术平台来指导系统、逐步实施系统和教育计划。该平台称为 Research about Research (RaR)，易于适应、符合 HIPPA 标准并支持通用数据标准的使用。我们将利用 DCRI、PI 和我们的联合研究人员的经验来调整 RaR，以支持区域和社区合作者之间的有效沟通、中央和区域研究管理的发展以及教育计划的实施，以运营 CHEER 网络。