A stable path for a core based scientist to advance imaging and cytometry in basic and preclinical research at the Karmanos Cancer Institute

为核心科学家在卡马诺斯癌症研究所的基础和临床前研究中推进成像和细胞计数提供了一条稳定的道路

• 批准号: 10026380
• 负责人: KAMIAR MOIN
• 金额: $ 28.06万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-13 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10026380
• 关键词: Applications Grants; Basic Science; Cancer Center; Cancer Center Support Grant; Capital; Collaborations; Communities; Computers and Advanced Instrumentation; Confocal Microscopy; Consultations; Continuing Education; Core Facility; Cytometry; Dependence; Educational workshop; Flow Cytometry; Funding; Grant; Image Cytometry; Individual; Institutes; International; Investigator-Initiated Research; Malignant Neoplasms; Methodology; Microscopy; Mission; Multimodal Imaging; Peer Review; Publications; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Resources; Role; Scientist; Services; Study Section; Techniques; Technology; Time; Tissue imaging; Travel; United States National Institutes of Health; Universities; analytical method; animal imaging; base; career; cellular imaging; confocal imaging; cost; experience; instrument; meetings; member; method development; microscopic imaging; operation; parent grant; pre-clinical research; ranpirnase; research facility; skills; symposium; technology development; technology validation; training opportunity

Abstract This proposal support for a core-based scientist with our Cancer Center Support Grant (CCSG) as the parent grant, seeks career stability for Dr. Kamiar Moin the Director of the Microscopy, Imaging and Cytometry Resources core (MICR) of the Karmanos Cancer Institute (KCI). MICR is the largest facility core of KCI and is funded, in part, by the CCSG (P30-CA022453, Dr. Gerold Bepler PI/Unit Director; Dr. Moin is a co-investigator). Dr. Moin established MICR in 1994 as the Confocal Imaging Core in the Cancer Center and provided cutting- edge expertise and state-of-the-art technology in fluorescent microscopy, confocal microscopy and related techniques. From the beginning with only a 200 ft2 space and one instrument, Dr. Moin has expanded and significantly upgraded the MICR a number of times culminating into the current premier multimodal imaging and flow cytometry service center with over 4000 ft2 space and 22 capital instruments. Dr. Moin’s mission through MICR is to support and enhance the peer reviewed funded research activities of our scientific community whose research requires advanced cytometry as well as cellular, tissue, and animal imaging and analysis. To fulfill this mission, Dr. Moin strives to consistently meet several objectives, which are to: 1) provide expertise in analytical methods development, technology development and validation, imaging and cytometry study design; 2) provide collaboration and consultation for grant proposals and publications; 3) provide and maintain state-of-the-art advanced instrumentation in flow cytometry, microscopy and imaging; 4) promote opportunities for intra- and inter-programmatic interaction among our scientific members; 5) minimize cost and effort for KCI investigators while increasing efficiency and 6) provide educational and training opportunities in microscopy, imaging and flow cytometry. Dr. Moin is a nationally and internationally recognized expert and leader in imaging and cytometry, evident by his service on 18 NIH study sections and numerous presentations and workshops, with over 30 years of experience and more than two decades of facility core management and administrative skills. His expertise in imaging and cytometry with a proven track record in technology and methods development is critical to the CCSG and the 25 NCI funded investigator-initiated research projects utilizing MICR. This application, if funded, will support 100% of his efforts and will offset some of the costs incurred by the individual NCI funded projects by reducing the chargeback rates. The R50 will provide career stability without dependence on individual grant and allows him to prioritize his effort on those projects that require methodology and technology development. The funds requested for travel will enable Dr. Moin to attend conferences in imaging and cytometry and/or core facility management meetings such as the Association of the Biomolecular Research Facilities (ABRF), to continue his education in imaging/cytometry and core management to be effective in his role to support the NCI funded projects.

抽象的 这项建议支持我们的核心科学家，我们的癌症中央支持补助金（CCSG）作为 父母格兰特（Grant Grant），为显微镜，成像和细胞仪主管Kamiar Moin博士寻求职业稳定 Karmanos癌症研究所（KCI）的资源核心（MICR）。 部分由CCSG（P30-CA022453）资助，Gerold Bepler Pi/单位主任； Moin博士是共同的遗物者）。 Moin博士于1994年建立了MICT，成为癌症中心的共聚焦成像核心，并提供了剪裁 荧光显微镜，共聚焦显微镜和相关的边缘专业知识和最先进的技术 从一开始就只有200 ft2空间，Moin博士扩大了 显着升级了MICT的数量，达到当前主要的多模式成像和 流式的cyottry服务中心，拥有超过4000 ft2空间和22个资本仪器。 MIC将支持和增强我们科学界的经过审查的资助的研究激活性 研究需要高级细胞仪以及细胞，组织和动物成像和分析。 任务，Moin博士努力始终达到几个目标，这些目标是：1）提供分析方面的专业知识 方法开发，技术开发和验证，成像和细胞仪研究设计； 为赠款和出版物提供协作和咨询； 3 流式细胞仪，显微镜和成像中的先进仪器促进 我们的科学成员之间的国内和国际互动的机会； KCI调查人员的成本和精力在提高效率的同时和6）提供教育和培训 显微镜，影像学和流式冠军的机会。 公认的成像和胞元学专家和领导者，他的服务于18个NIH研究部分的服务证明了这一点 众多的天堂和讲习班，拥有30多年的经验和超过二十年的设施 核心管理和行政技能。 技术和方法开发对CCSG和25个NCI资助的研究者发起的至关重要 使用MICR的研究项目（如果资助）将支持他的100％ NCI基金会降低R50的成本 提供职业稳定性并依赖个人赠款，并允许他优先考虑自己的努力 那些需要方法和技术开发的项目。 使Moin博士能够参加成像和细胞仪和/或核心设施管理会议的会议会议 作为生物分子研究设施（ABRF）的协会，继续他的教育 成像/细胞仪和核心管理有效地支持NCI资助的项目。