Understanding and testing recovery processes for PTSD and alcohol use following sexual assault

了解和测试性侵犯后创伤后应激障碍和酗酒的恢复过程

基本信息

批准号：
10021535
负责人：
MICHELE A BEDARD-Gilligan
金额：
$ 48.6万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10021535
关键词：
Address Affective Alcohol consumption Alcohols Anhedonia Animals Behavioral Biological Chronic Chronic Post Traumatic Stress Disorder Clinical Clinical Trials Design Depression and Suicide Development Early Intervention Exposure to Extinction (Psychology)Fright Health Care Costs Human Impairment Individual Intervention Lead Learning Link Maintenance Measures Memory Mental Health Outcome Participant Patient Self-Report Patients Performance Phase Post-Traumatic Stress Disorders Process Psychopathology Randomized Randomized Clinical Trials Recovery Regulation Reporting Research Research Design Resistance Rewards Risk Role Safety Signal Transduction Stress Survivors Symptoms System Testing Time Trauma Treatment Efficacy Woman Yin-Yang active control alcohol misuse alcohol use disorder assault base binge drinking brief intervention clinical decision-making comparative efficacy coping design drinking effective intervention efficacy testing experience follow-up improved intervention effect neurotransmission novel personalized predictions post-traumatic stress prevent response sexual assault skills skills training substance misuse telehealth trauma exposure

项目摘要

PROJECT SUMMARY Following sexual assault, many individuals will develop chronic problems including posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD). Intervention provided soon after assault can decrease the risk of developing chronic psychopathology and associated negative consequences. Interventions that address common underlying mechanisms of PTSD and alcohol use, such as fear and reward systems, have strong potential utility as efficacious and accessible interventions for clinicians treating patients recently exposed to sexual assault. This proposal is designed to test fear and reward as crucial processes underlying recovery following sexual assault and elucidate the most efficacious treatment targets. Employing experimental tasks (safety-signal learning paradigm and probabilistic reward task) to capture baseline underlying vulnerabilities in fear and reward systems respectively will allow for exploration of how these processes impact recovery. A randomized clinical trial (N = 180) will be conducted to test efficacy of intervention approaches that target PTSD or alcohol use compared to supportive telehealth. In addition, a phased study design will allow for exploration of efficacy of primary and secondary intervention approaches to test the questions of 1) whether it is more efficacious to target PTSD or alcohol use first; and 2) whether it is necessary to target both PTSD and alcohol use to facilitate recovery or if one is sufficient. This proposal is significant in exploring transdiagnostic mechanisms implicated in recovery following sexual assault, fear and reward, and using a novel design to compare efficacy, ordering, and necessity of two distinct intervention approaches.

项目摘要性侵犯后，许多人会遇到慢性问题，包括创伤后压力疾病（PTSD）和酒精使用障碍（AUD）。攻击后不久提供的干预可以减少发展慢性心理病理学和相关的负面后果的风险。解决的干预措施 PTSD和饮酒的常见基本机制，例如恐惧和奖励系统，具有强大的潜在的效用作为治疗最近接触的患者的临床医生的有效且可及的干预措施性侵犯。该提案旨在测试恐惧和奖励，因为恢复的基础关键过程性侵犯并阐明了最有效的治疗目标。采用实验任务（安全信号学习范式和概率奖励任务）捕获基准的基准漏洞恐惧和奖励系统将分别允许探索这些过程如何影响恢复。一个将进行随机临床试验（n = 180），以测试针对目标的干预方法的功效与支持性远程医疗相比，PTSD或酒精使用。此外，分阶段的研究设计将允许探索主要和次要干预方法测试问题的功效1）是否首先针对PTSD或酒精饮酒更有效； 2）是否有必要针对PTSD和饮酒以促进恢复或是否足够。该提议对于探索转诊的意义很重要在性侵犯，恐惧和奖励之后与恢复有关的机制，并使用新颖的设计来比较两种不同的干预方法的功效，有序和必要性。