The effect of poverty, stress and immune function on health across the life-course

贫困、压力和免疫功能对生命全程健康的影响

基本信息

批准号：
10015191
负责人：
Sudhanshu Handa
金额：
$ 53.02万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-15 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10015191
关键词：
19 year old Address Adolescence Adult Affect Africa Age Aging Alcohol consumption Behavioral Biological Biological Markers Blood Child Health Chronic Disease Chronic stress Comb animal structure Control Groups Country Data Data Set Disease Disease susceptibility Economics Elderly Evaluation Explosion Exposure to Female Goals Government Health Household Hypertension Immune System Diseases Immune response Immune system Immunologic Tests Income Individual Infection Inflammation Intervention Interview Kenya Knowledge Life Life Cycle Stages Link Low income Malawi Maps Measures Mediating Memory Mental Health National Institute on Aging Pathway interactions Personal Satisfaction Physiological Poverty Process Psychosocial Stress Public Policy Questionnaires Randomized Research Respondent Risk Role Rural Sampling Sampling Studies Schools Societal Factors Spottings Stress Structure Surveys Testing Time World Bank alcohol risk base behavioral economics beneficiary cognitive capacity cohort control trial design disorder risk experience healthy aging immune function immune health low and middle-income countries member middle age mortality risk physical conditioning post intervention poverty alleviation poverty reduction preference programs psychologic satisfaction social study population trial design young adult

项目摘要

Abstract This project will assess the medium-term impact of a large-scale national anti-poverty program on disease and health risk of mature adults (age 45+) and young adults (age 20-26). We build on a longitudinal randomized control trial designed to evaluate the impact of an unconditional cash transfer program in a low-income setting. A fourth wave of data on the study population will include new measures of immune response, disease risk, and cognitive capacity. Combing these measures with information from previous waves, including the pre- intervention period, will allow us to map out the biological, behavioral and economic pathways through which a cash transfer program influences health at two points in the life-cycle. Specifically, we will exploit the exogenous change in income evoked by random assignment to early-entry treatment condition to estimate the causal effect of income poverty on immune function, and the role of stress in mediating this relationship. We will also estimate the causal effect of the cash transfer on a range of indicators of disease risk. Half the young adults in our sample were exposed to the cash transfer during their critical adolescence years, allowing us to estimate the impact of the cash on their disease risk. By providing estimates for both mature and younger adults, we can observe whether the hypothesized relationship vary across the life-course. The proposal addresses the National Institute of Ageing's Goal B to `better understand the effects of personal, interpersonal, and societal factors on ageing, including mechanisms through which these factors exert their effects.' Within Goal B, the proposal responds to objective B1: `Illuminate the pathways by which social, psychological, economic, and behavioral factors affect health in middle-aged and older adults.'

抽象的该项目将评估大规模国家反贫困计划对疾病和贫困的中期影响。成年人（45 岁以上）和年轻人（20-26 岁）的健康风险。我们建立在纵向随机旨在评估无条件现金转移计划对低收入环境的影响的对照试验。关于研究人群的第四波数据将包括免疫反应、疾病风险、和认知能力。将这些措施与之前浪潮的信息相结合，包括预干预期，将使我们能够绘制出生物、行为和经济途径，通过这些途径现金转移计划在生命周期的两个阶段影响健康。具体来说，我们将利用随机分配早期进入所引起的收入外生变化用于估计收入贫困对免疫功能的因果影响的治疗条件以及压力的作用在调解这种关系的过程中。我们还将估计现金转移对一系列因素的因果影响疾病风险指标。我们样本中的一半年轻人在他们的童年时期接触过现金转移关键的青春期，使我们能够估计现金对其疾病风险的影响。通过提供对于成年人和年轻人的估计，我们可以观察假设的关系是否有所不同贯穿生命历程。该提案提出了国家老龄化研究所的目标 B“更好地了解个人、人际和社会因素对衰老的影响，包括衰老的机制这些因素发挥了作用。在目标 B 中，该提案回应了目标 B1：“照亮道路” 社会、心理、经济和行为因素影响中老年人的健康。