Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE)

通过基于神经可塑性的计算机化运动 (INHANCE) 改善衰老过程中的神经健康

• 批准号: 10019442
• 负责人: Mouna Attarha
• 金额: $ 59.39万
• 依托单位: POSIT SCIENCE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10019442
• 关键词: Acetylcholine; Address; Adopted; Age-associated memory impairment; Aging; Alzheimer' s Disease; American; Attention; Automobile Driving; Behavioral; Benchmarking; Biological Assay; Brain; Cognition; Cognitive; Dementia; Dementia caregivers; Deterioration; Devices; Dose; Double-Blind Method; Economics; Elderly; Emotions; Epidemiology; Exercise; Family; Financial cost; Funding; Goals; Hand; Health; Healthcare Systems; Imaging ligands; Impairment; Individual; Internet; Intervention; Light; Longevity; Measures; Medical; Minor; Moods; Nervous System Physiology; Neurodegenerative Disorders; Neurologic; Neuronal Plasticity; Neuropsychology; Outcome; Pathologic; Patients; Persons; Pharmacotherapy; Phase; Pilot Projects; Placebos; Positron-Emission Tomography; Prevention; Price; Process; Prosencephalon; Quality of life; Randomized Clinical Trials; Research; Research Personnel; Resources; Schedule; Sleep; Small Business Innovation Research Grant; Societies; System; Task Performances; Therapeutic; Time; Training; Training Programs; Translations; United States National Institutes of Health; Universities; Up-Regulation; active control; aging population; alertness; arm; attentional control; base; brain health; care costs; cholinergic; clinically significant; cognitive performance; cognitive training; cohort; comparative efficacy; comparison intervention; computerized; computerized tools; cost; dementia risk; design; dosage; executive function; follow-up; geriatric depression; improved; indexing; instrumental activity of daily living; neurophysiology; neuroregulation; normal aging; primary outcome; processing speed; productivity loss; programs; skill acquisition; success; tool

PROJECT ABSTRACT Advancing age is often accompanied by a decline of key neuromodulatory centers of the brain that support adaptive neuroplasticity. Deterioration of the underlying neurophysiology of the brain predisposes the individual to pathological and age-related cognitive decline. We propose to deploy a computerized cognitive training program (INHANCE) developed via two successful SBIR-funded phase II programs (R44AG039965; R44NS071780). The program will combine two previously validated, but historically independent, exercises that based on prior research may interact to reduce the long-term risk of dementia onset. We shall conduct a double-blind, parallel-arm, placebo-controlled, randomized clinical trial that will assess the short- and long-term efficacy of the program to improve neuromodulatory status (via positron-emission tomography) and neuropsychological outcomes (via standard assessment measures). The broader objectives of the project are two-fold. One is to address the rapid rise in neurodegenerative disease and the other is to shed light on the underlying neuromodulatory mechanism(s) through which certain forms of cognitive training achieve neuropsychological improvement. An effective, low-cost, and highly-scalable program available on the most popular internet-connected devices offers global reach and the possibility of extending the cognitive health of older adults. With effective computerized tools in hand we can enrich the lives of patients and their families, alleviate the enormous financial cost associated with minor and major forms of impairment, and progress swiftly toward the goal of creating a healthier society and a more efficient healthcare system.

项目摘要 增长年龄通常伴随着支持适应性的关键神经调节中心的下降 神经可塑性。大脑的潜在神经生理学恶化使人偏见病理学和 与年龄有关的认知下降。我们建议部署通过计算机化的认知培训计划（Inhance） 两个成功的SBIR资助II期计划（R44AG039965; R44NS071780）。该程序以前将结合两个 经过验证但历史上独立的，基于先前研究的练习可能会互动以减少长期风险 痴呆发作。我们将进行双盲，平行臂，安慰剂对照，随机临床试验，以评估 该计划改善神经调节状态的短期和长期疗效（通过正电子发射断层扫描） 和神经心理学结果（通过标准评估措施）。该项目的更广泛的目标是两个方面。 一种是解决神经退行性疾病的快速上升，另一种是阐明潜在的神经调节性 某些形式的认知训练实现神经心理学改善的机制。有效， 在最受欢迎的Internet设备上可用的低成本且高度可观的程序可提供全球范围和 扩展老年人认知健康的可能性。借助有效的计算机工具，我们可以丰富 患者及其家人的生活减轻了与次要和主要形式相关的巨大财务成本 损害，并迅速朝着建立更健康的社会和更有效的医疗体系的目标迅速发展。