Regional Training Center for Tropical Disease Research in Quito-Ecuador

厄瓜多尔基多热带病研究区域培训中心

• 批准号: 8130665
• 负责人: MARIO J GRIJALVA
• 金额: $ 14.9万
• 依托单位: OHIO UNIVERSITY ATHENS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-12 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8130665
• 关键词: Algorithms; Biological; Chagas Disease; Clinical; Collaborations; Communicable Diseases; Country; Detection; Development; Diagnostic; Disease; Ecuador; Evaluation; Faculty; Fostering; Genotype; Health; Health Policy; Housing; Human Resources; Infectious Diseases Research; Institution; Knowledge; Lead; Methods; Morbidity - disease rate; Ohio; Pattern; Population Distributions; Positioning Attribute; Principal Investigator; Public Health; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Role; Scientist; Solid; South America; Training; Training Programs; Tropical Disease; Trypanosoma cruzi; Universities; disorder control; improved; mortality; neglect; pre-doctoral; programs; sound; square foot; transmission process

DESCRIPTION (provided by applicant): The lack of adequately trained scientists and research infrastructure is the under lying cause of the lack of basic knowledge to guide the implementation and evaluation of effective public health programs as well as informed health policies in Ecuador. The overall objective of this proposal is to obtain biological and clinical information that will improve current Chagas disease control efforts in Ecuador, while implementing a sound and sustainable training program in infectious disease research. The training program proposed herein will take advantage of the strong collaborative relationship established in the 1990's between Ohio University (OU) and Catholic University of Ecuador (PUCE), and the track record of successful research and training collaboration carried out by these institutions. The program will focus on long term training at the postdoctoral and predoctoral levels. Trainee research projects will be nested into three ongoing interrelated research initiatives currently led by the P.D. and collaborating faculty in Ecuador. These initiatives include: 1. the development of improved standardized genotyping methods for T. cruzi, and their use for Trypanosoma cruzi strain characterization; 2. determination of Triatomine distribution and population flow, including house infestation and re-infestation patterns, and their relationship with T. cruzi genotypes; and 3. determination of the relationship between Chagas disease morbidity and mortality with T. cruzi strains present in the country and improvement of current case detection and diagnostic algorithms. The proposal contains a solid plan for the recruitment of trainees into technical and faculty positions that will be at PUCE. In addition, the program provides a framework for the recruitment of Ecuadorians who have received advanced degrees outside of Ecuador. The increase of in-house research expertise will lead to the establishment of a "Regional Training Center for Tropical Disease Research" in Quito-Ecuador. The program will be housed in a new 70,000 square feet building being constructed by PUCE in its new campus near Quito, to be completed by 2013. This facility will have the capacity to house the labs and offices of 16 principal investigators, associated staff, and research trainees. Overall, the proposed training program will help alleviate the severe lack of well trained technical personnel and researchers in Ecuador, foster the role of scientists as efficient public health policymakers, and have an important effect in the research capability of Ecuador. PULBIC HEALTH RELEVANCE: Ecuador lags far behind other countries of South America in terms of control of transmission of Chagas disease and other infectious diseases due in part to the lack of adequate research infrastructure and trained personnel. This training program will build the capacity of Catholic University of Ecuador to conduct high level research that can contribute to the control of this and other neglected diseases.

描述（由申请人提供）：缺乏经过足够培训的科学家和研究基础设施是缺乏基本知识来指导和评估有效公共卫生计划的实施和评估以及厄瓜多尔知情的健康政策的谎言。该提案的总体目的是获得生物学和临床信息，以改善厄瓜多尔当前的Chagas疾病控制工作，同时在传染病研究中实施合理和可持续的培训计划。本文提出的培训计划将利用俄亥俄州大学（OU）和厄瓜多尔天主教大学（PUCE）之间在1990年代建立的牢固的合作关系，以及这些机构进行的成功研究和培训合作的记录。该计划将重点介绍博士后和杂物级别的长期培训。受训人员研究项目将嵌套到目前由P.D.并在厄瓜多尔合作。这些举措包括：1。用于改进的克鲁齐（T. Cruzi）的标准化基因分型方法的发展及其用于锥虫菌株菌株表征的使用； 2。确定三局分布和人口流量，包括房屋的侵扰和重新侵入模式，及其与克鲁兹基因型的关系；和3。确定Chagas疾病发病率与死亡率与该国存在的T. Cruzi菌株之间的关系以及当前病例检测和诊断算法的改善。该提案包含一个可靠的计划，可以将学员招募到PUCE的技术和教职员工职位。此外，该计划为招募厄瓜多尔以外获得高级学位的厄瓜多尔人提供了一个框架。内部研究专业知识的提高将导致在Quito-Ecuador建立“热带疾病研究中心”。该计划将安置在PUCE在基多附近的新校园中建造的新的70,000平方英尺的建筑中，该建筑将于2013年完成。该设施将有能力容纳16名主要调查员，关联员工和相关人员和办公室的实验室和办公室研究学员。总体而言，拟议的培训计划将有助于减轻厄瓜多尔训练有素的技术人员和研究人员的严重缺乏，促进科学家作为有效的公共卫生决策者的作用，并对厄瓜多尔的研究能力产生重要影响。 PULBIC健康相关性：厄瓜多尔落后于南美其他国家的控制，就chagas疾病的传播和其他传染病的控制而言，部分原因是由于缺乏足够的研究基础设施和训练有素的人员。该培训计划将建立厄瓜多尔天主教大学的能力进行高水平研究，以控制这种疾病和其他被忽视的疾病。