The Administrative Core will support Udall Center activities at the University of Rochester

行政核心将支持罗切斯特大学尤德尔中心的活动

基本信息

批准号：
10017334
负责人：
Earl Ray Dorsey
金额：
$ 24.44万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10017334
关键词：
Advocacy Big Data Caring Cellular Phone Clinical Markers Clinical Research Clinical Sciences Clinical Trials Clinical and Translational Science Awards Communities Computational Science Computers Country Data Science Data Scientist Development Disease Progression Disease model Electrical Engineering Enrollment FDA approved Fellowship Fellowship Program Funding Generations Genetic Markers Grant Health Health Technology Individual Infrastructure Institutes Institution Interdisciplinary Study Investigational Therapies Leadership Mission Movement Disorders Neurology Participant Pharmacologic Substance Positioning Attribute Randomized Controlled Trials Recording of previous events Research Research Personnel Resources Role Scientist Technology Telemedicine Therapeutic Training Training Programs Translational Research United States National Institutes of Health Universities University resources advanced analytics advocacy organizations career development clinical center health professional shortage areas human capital innovation multidisciplinary novel novel strategies outreach research and development research study tool virtual wearable sensor technology

项目摘要

SUMMARY The UR-Udall Center's Administrative Core will utilize the established resources of the University of Rochester's Center for Health + Technology (CHeT). Over the past 25 years, CHeT has pioneered multi-center research studies that have enrolled 40,000 individuals in 120 studies that have led to seven FDA-approved therapies, including four for PD. More recently, CHeT has used technology to transform PD research and care. Among these PD initiatives are disease models that have identified novel clinical and genetic markers of disease progression, the first two virtual PD research studies, the two largest smartphone studies in PD, the first longitudinal wearable sensor study for PD, and the only national randomized controlled trial of telemedicine for PD. The University's Goergen Data Science Institute and the University of Rochester's Clinical and Translational Science Institute will support the Administrative Core. In addition, a multidisciplinary network of leading investigators from top institutions, including Johns Hopkins, Aston University, and MIT, and innovative collaborators, such as 23andMe and Sage Bionetworks, will guide and assist with executing the UR-Udall Center's activities. The Administrative Core will conduct unparalleled outreach at the state, national, and global level. CHeT will utilize its statewide telemedicine network, which cares for hundreds in health professional shortage areas, to bring research opportunities to individuals in their communities. Working with the nation's largest advocacy organizations, the Core will enable national participation in research. Using its recently launched ParkinsonTV, the UR-Udall Center will reach 100,000's of individuals globally to educate them about PD and novel research. Finally, the Core will leverage the Department of Neurology's T32 fellowship program in experimental therapeutics, as well as extensive research and career development opportunities, to assemble and cross-train clinician-scientists and 10-20 computer scientists, mathematicians, and electrical engineers in PD research to create the first collaborative group of PD investigators with both clinical research and computational science expertise. This influx and development of scarce human capital will be one of the UR-Udall Center's many enduring and valuable contributions to the field.

概括 UR-尤德尔中心的行政核心将利用大学的现有资源罗切斯特健康+技术中心 (CHeT)。在过去的 25 年里，CHeT 开创了多中心 120 项研究招募了 40,000 名受试者，其中 7 项研究已获得 FDA 批准疗法，包括四种针对帕金森病的疗法。最近，CHeT 利用技术来改变 PD 研究和护理。在这些 PD 计划中，有一些疾病模型已确定了新的临床和遗传标记疾病进展、前两项虚拟 PD 研究、两项最大的 PD 智能手机研究、第一个针对帕金森病的纵向可穿戴传感器研究，也是唯一的国家随机对照试验 PD 远程医疗。该大学的格尔根数据科学研究所和罗切斯特大学的临床和转化科学研究所将支持行政核心。此外，还建立了一个多学科网络来自约翰霍普金斯大学、阿斯顿大学和麻省理工学院等顶级机构的领先研究人员和创新 23andMe 和 Sage Bionetworks 等合作者将指导和协助执行 UR-Udall 中心的活动。行政核心将在州、国家和全球层面开展无与伦比的外展活动。切特将利用其全州远程医疗网络，为卫生专业人员短缺地区的数百人提供护理，为社区中的个人带来研究机会。与全国最大的倡导组织合作组织，核心将使国家参与研究。使用最近推出的 ParkinsonTV， UR-Udall 中心将覆盖全球 100,000 人，向他们提供有关 PD 和新颖研究的教育。最后，核心将利用神经病学系的 T32 研究金计划进行实验疗法以及广泛的研究和职业发展机会，以进行组装和交叉训练临床医生科学家和 10-20 名计算机科学家、数学家和电气工程师参与 PD 研究，创建第一个由临床研究和计算科学领域的 PD 研究人员组成的合作小组专业知识。稀缺人力资本的涌入和发展将成为 UR-Udall 中心的众多优势之一对该领域做出持久且有价值的贡献。