Research Project 4 will develop novel, objective, and passive measures of Parkinson disease features

研究项目 4 将开发帕金森病特征的新颖、客观和被动的测量方法

• 批准号: 10459493
• 负责人: Earl Ray Dorsey
• 金额: $ 42.64万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10459493
• 关键词: 3-Dimensional; Accelerometer; Affect; Blinded; Caring; Cellular Phone; Clinic; Clinical assessments; Collection; Colon Carcinoma; Computers; Country; Data; Data Collection; Devices; Disease; Effectiveness; Electrical Engineering; Electrocardiogram; Elements; Exhibits; Facial Expression; Fingers; Gait; Gait speed; Home; Individual; Levodopa; Longitudinal Studies; Measures; Michigan; Middle Insomnia; Motor; Movement; Movement Disorder Society Unified Parkinson' s Disease Rating Scale; Natural History; Parkinson Disease; Participant; Pattern; Pharmaceutical Preparations; Radio Waves; Research; Research Personnel; Research Project Grants; Scientist; Severity of illness; Sleep; Socialization; Technology; Time; Universities; Voice; Walking; advanced analytics; analytical tool; heart rate variability; improved; insight; machine learning algorithm; motor disorder; next generation; novel; respiratory; response; sensor; smartphone Application; therapeutic development; therapeutic evaluation; tool; wearable sensor technology

SUMMARY New sensing devices can generate objective, frequent, sensitive assessments of PD. However, many devices, like smartphones, require individuals to complete activities. Because PD, unlike colon cancer, for example, has clear external features (e.g., slow gait, frequent sleep interruptions), it is well suited for passive assessment. In Research Project 4, we will evaluate three leading technologies to assess PD principally (but not exclusively) through passive means. These technologies include wearable sensors that can measure motor and autonomic function, a video analytical tool that can measure elements of the standard PD motor examination, and an “invisible” radio wave sensing tool that can assess the natural history of PD in the home. These three tools will enhance our understanding and generate objective measures of PD that can be used to accelerate therapeutic development and improve care. The first project will examine a wearable sensor that has embedded accelerometers, gyroscope, and ECG capabilities to assess function inside and outside the clinic. In one of the largest PD sensor studies, we will seek to confirm and extend findings that individuals with PD exhibit distinct diurnal activity patterns from controls (e.g., lie down more, walk less), evaluate autonomic function, and in partnership with the University of Michigan's Udall Center, explore whether gait function is worse in individuals with a hypocholinergic state. The second project will evaluate a recently developed video analytics tool that applies machine learning algorithms to evaluate motor assessments (e.g., facial expression, finger tapping) that are routinely assessed through the motor portion the MDS-UPDRS to see if these assessments, conducted without an investigator, can differentiate those with PD from those without and correlate with traditional assessments. The third project will evaluate motor and non-motor function of individuals with PD in their homes using a novel radio wave sensing device. This device can assess existing measures (e.g., gait speed, respiratory rate) and novel measures (e.g., path tortuosity, time alone) that will provide novel insights into the disease.

概括 新的传感设备可以客观地生成频繁、敏感的局部放电评估。然而，许多设备评估， 与智能手机一样，需要个人完成活动，因为 PD 与结肠癌不同。 清晰的外部特征（例如，缓慢的步态、频繁的睡眠中断），非常适合被动评估。 在研究项目4中，我们将评估三种领先的技术来主要评估PD（但不包括 这些技术包括可以测量电机的可穿戴传感器。 和自主功能，一种视频分析工具，可以测量标准 PD 电机的元件 检查，以及一种“隐形”无线电波传感工具，可以评估家中帕金森病的自然史。 这三个工具将增强我们的理解并生成可用于 PD 的客观衡量标准 加速治疗发展并改善护理。 第一个项目将检查嵌入加速度计、陀螺仪和心电图的可穿戴传感器 在最大的局部放电传感器研究之一中，我们将评估诊所内外的功能。 寻求证实并扩展 PD 患者表现出与其他患者不同的昼夜活动模式的发现 控制（例如，多躺，少走），评估自主功能，并与大学合作 密歇根州尤德尔中心探索胆碱能低下状态的个体步态功能是否更差。 第二个项目将评估最近开发的应用机器学习的视频分析工具 用于评估常规评估的运动评估（例如面部表情、手指敲击）的算法 通过 MDS-UPDRS 的运动部分来查看这些评估是否在没有研究者的情况下进行， 可以区分患有帕金森症的人和没有帕金森病的人，并与传统评估相关联。 第三个项目将使用一种新颖的方法在家中评估帕金森病患者的运动和非运动功能 无线电波传感设备。该设备可以评估现有的测量值（例如步态速度、呼吸频率）和 新的措施（例如，路径曲折、独处时间）将为疾病提供新的见解。