Influences of Early and Later Life Events on Cognition and All-Cause Dementia in China

中国早年和晚年生活事件对认知和全因痴呆的影响

基本信息

批准号：
10017858
负责人：
James Patrick Smith
金额：
$ 53.95万
依托单位：
ROSE LI AND ASSOCIATES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-15 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10017858
关键词：
Adult Affect Age Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Americas Childhood China Chinese People Cognition Cognitive Communities Country Data Dementia Diabetes Mellitus Earthquakes Economics Education Elderly Employee Environmental Risk Factor Event Extended Family Family Famines Friends Funding Geography Goals Government Officials Growth Health Health and Retirement Study Impaired cognition Incidence Individual Interview Lead Life Life Cycle Stages Life Expectancy Link Literature Longitudinal Studies Measures Mental Depression Modeling Natural Disasters Obesity Older Population Paper Patients Physical environment Politics Population Population Study Publishing Recording of previous events Research Resources Respondent Retirement Risk Risk Factors Sampling Smoking Social isolation Societies Socioeconomic Status Stressful Event Surveys United States Visual impairment Woman cognitive ability cost dementia risk design drinking farmer follow-up gender difference hearing impairment improved life history lifestyle factors low income country men middle age novel outcome prediction physical inactivity protective factors public health relevance trend

项目摘要

Abstract Rising life expectancy is contributing to rapid increases in the size of the older population and is expected to lead to a sharp rise in Alzheimer’s disease and Alzheimer’s disease related dementias from about 47 million people worldwide today, to potentially more than 140 million in 2050. However, recent population studies have found that the incidence of Alzheimer’s disease and Alzheimer’s disease related dementias is lower than that indicated by previous projections in some countries, but greater in others. Lifestyle factors as well as environmental factors might reduce or increase an individual’s risk of developing dementia. We propose to advance our understanding of protective and risk factors for late-life cognitive decline and Alzheimer’s disease and Alzheimer’s disease-related dementias (hereafter referred to as dementia) in China. We propose a novel life-course model of risk factors, building on the recently proposed model by the Lancet commission, which links dementia risk to early and mid-life factors, within the context of historical, institutional, and physical environments, including obesity, diabetes hearing loss, visual impairment, smoking, drinking, depression, physical inactivity, social isolation, and socioeconomic status. Specifically, this project aims to further study early and mid-life personal, family, community, and external factors that may contribute to late-life cognition and dementia risk using new, retrospective life-history interview data in China.

抽象的预期寿命的延长导致老年人口规模迅速增加，预计将导致阿尔茨海默病和阿尔茨海默病相关痴呆症患者急剧增加，从目前全球约 4700 万人增加到 2050 年可能超过 1.4 亿。最近的人口研究发现，在一些国家，阿尔茨海默病和阿尔茨海默病相关痴呆的发病率低于之前的预测，但在其他国家，生活方式因素以及环境因素可能会降低或更高。我们建议加深对中国晚年认知能力下降和阿尔茨海默病以及阿尔茨海默病相关痴呆（以下简称痴呆）的保护和危险因素的了解。风险因素的课程模型，以柳叶刀委员会最近提出的模型为基础，该模型将痴呆症风险与早年和中年因素联系起来，在历史、制度和物理环境的背景下，包括肥胖、糖尿病、听力损失、视力障碍, 吸烟, 饮酒, 抑郁, 身体具体来说，该项目旨在通过新的回顾性生活史访谈进一步研究可能导致晚年认知和痴呆风险的早年和中年个人、家庭、社区和外部因素。中国的数据。