Songmaking in a Group (SING): Music, Hallucinations & Predictive Coding

团体歌曲制作（SING）：音乐、幻觉

• 批准号: 10015353
• 负责人: PHILIP CORLETT
• 金额: $ 40.76万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-10 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10015353
• 关键词: Analysis of Variance; Auditory Hallucination; Behavior; Behavioral; Belief; Biological Assay; Brain; Cells; Chemosensitization; Clinical Trials; Code; Complex; Computational Linguistics; Computer Models; Cues; Distress; Event; Expectancy; Family member; Friends; Functional disorder; Future; Hallucinations; Hearing; Impairment; Individual; Intervention; Interview; Laboratories; Language; Learning; Light; Linguistics; Measures; Meta-Analysis; Mind; Modeling; Music; Neurons; Overweight; Ownership; Participant; Perception; Performance; Periodicity; Personal Satisfaction; Pharmacotherapy; Phase; Procedures; Property; Psychiatrist; Psychiatry; Psychotherapy; Psychotic Disorders; Publishing; Qualitative Research; Quality of life; Recording of previous events; Recovery; Research; Research Personnel; Rewards; Scheme; Self Concept; Series; Stimulus; Symptoms; Synaptic plasticity; Task Performances; Testing; Toes; Uncertainty; Update; Voice; Work; base; design; expectation; experience; follow-up; improved; lexical; musician; power analysis; psychotic symptoms; severe mental illness; social; social engagement; social learning

Abstract People with psychotic illnesses perceive and believe things about themselves, the outside world and other people that do not obtain. This can be very distressing for them, their family members and friends. Listening to and performing music can help mitigate this distress, but we do not know why. This project aims to find out. Perceiving and believing, about self and others, is achieved by making predictions and updating those predictions in light of new evidence, particularly if that new evidence is very reliable or precise. One way that music might help psychosis involves this precision. By making one set of predictions more precise—predictions about music— other predictions can change. This might be why we tap our toes or sing along to music we enjoy. We propose that experiencing more reliable predictions about ones’ actions (by singing) and other people (by singing along with them) will help to change the predictions that underwrite the symptoms of psychosis. We will test whether this is true in an initial R61 study, tracking the change in performance of a series of prediction-based tasks as a result of musical experience by prosecuting three specific aims: Specific Aim 1 will examine the impact of song- making in a group (SING) on conditioned hallucination task performance, a procedure that safely and reliably engenders hallucinations in the laboratory. We predict SING will reduce the number and mechanisms of hallucinations in the laboratory. Specific Aim 2 will examine how social learning changes with SING. Using a reputation learning task, we will measure social learning rates. We predict they will increase with SING. Specific Aim 3 will examine participants’ subjective experience of self-hood and how they change with SING using computational linguistic analysis. We predict SING will decrease linguistic markers of distress. If those studies prove successful, we will – in a follow-up R33 study – use metrics from the R61 to decompose the musical intervention into its key ingredients – asking whether it is important to be active (or merely passively experience music), and whether owning the music produced is important to its impact on precision of processing. These studies will help us refine whether, how and to whom we deliver musical intervention for serious mental illness.

抽象的 患有精神病的人会感知并相信自己，外界的事情 和其他未获得的人。这对他们来说可能非常痛苦，他们的家人 和朋友。聆听和表演音乐可以帮助减轻这种困扰，但我们没有 知道为什么。该项目旨在找出答案。关于自我和他人的感知和相信是 通过做出预测并根据新证据更新这些预测来实现 特别是如果新证据非常可靠或精确。音乐可能会有所帮助的一种方式 精神病涉及这种精度。通过使一组预测更加精确 - 预测 关于音乐 - 其他预测可能会改变。这可能就是为什么我们敲脚趾或唱歌 我们喜欢的音乐。我们建议对自己的行为进行更可靠的预测（通过 唱歌）和其他人（通过与他们一起唱歌）将有助于改变预测 承保精神病的症状。我们将在最初的R61研究中测试这是否是正确的， 跟踪音乐的一系列基于预测任务的性能的变化 通过起诉三个具体目标的经验：特定目标1将检查歌曲的影响 - 在有条件的幻觉任务绩效的小组中（唱歌），该程序 安全可靠的实验室幻觉。我们预测Sing将减少 实验室幻觉的数量和机制。特定目标2将检查如何 社交学习随着唱歌而变化。使用声誉学习任务，我们将衡量社交 学习率。我们预测他们会随着唱歌而增加。具体目标3将检查 参与者的自我自我的主观经验以及他们如何随着唱歌而改变 计算语言分析。我们预计Sing将减少遇险的语言标志。如果 这些研究证明了成功，我们将在一项后续R33研究中使用R61的指标 将音乐干预分解成其关键成分 - 询问它是否重要 保持活跃（或仅仅是被动体验音乐），以及是否拥有所产生的音乐是 对其对处理精度的影响很重要。这些研究将帮助我们完善是否，是否 我们如何以及向谁提供音乐干预，以解决严重的精神疾病。