Core 1: Clinicopathological Analysis and Disease Modeling

核心 1：临床病理学分析和疾病建模

• 批准号: 10705098
• 负责人: Iman Osman
• 金额: $ 26.09万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705098
• 关键词: American; Animal Model; Artificial Intelligence; Award; Biological; Clinical; Collaborations; Data; Disease model; Ensure; Generations; Genetic Engineering; Goals; Health; Human; Human Resources; Imaging technology; Immunofluorescence Immunologic; Institution; International; Link; Mission; Modeling; Molecular; Mus; Neoplasm Metastasis; New York; Pathogenicity; Pathologic; Pathologist; Pathology; Patients; Pilot Projects; Process; Quality Control; Research; Research Infrastructure; Research Project Grants; Resources; Role; Sampling; Services; Societies; Technology; Testing; Translational Research; Universities; Validation; Work; Xenograft procedure; animal tissue; cancer type; college; community center; cost effective; cost effectiveness; digital; human tissue; innovation; melanoma; member; mouse model; new technology; novel; programs; prospective; repository; success; transcriptomics; tumor

CLINICOPATHOLOGICAL ANALYSIS AND DISEASE MODELING CORE SUMMARY The primary objective of the Clinicopathological Analysis and Disease Modeling Core (Core B) is to catalyze the New York University Langone Health (NYULH) Metastasis Research Network Center’s research goals by providing high-quality, clinically annotated melanoma biospecimens, expertise in human and animal tissue analyses, and cutting-edge technological resources. To execute the central scientific strategy of the NYULH Metastasis Research Network Center, Core B will 1) procure both retrospective and prospective melanoma patient samples needed for cross-validation of murine data and hypothesis generation for animal model testing, 2) refine cutting-edge imaging technologies for multispectral immunofluorescence analyses, and 3) provide expertise in the pathological assessment of post- experimental mouse and human tissues to support the 3 main projects as well as pilot projects. Through a governance committee, Core B will also provide oversight of biospecimen use. Leveraging the resources of NYULH Melanoma Program including the recently awarded SPORE, Core B will serve both the NYULH Metastasis Research Network Center community as well as other Centers of the Network, avoiding duplication of efforts and maximizing cost-effectiveness and efficiency. Overall, Core B will provide high quality, annotated melanoma patient biospecimens, cutting-edge technological resources, and pathological expertise to all Center studies to support the NYULH Metastasis Research Network Center’s mission to uncover determinants of melanoma metastasis, focused on drivers of early dissemination and cross-talk with micro-environmental components.

临床病理分析和疾病建模核心摘要 临床病理分析和疾病建模核心（核心 B）的主要目标是催化 纽约大学朗格健康中心 (NYULH) 转移研究网络中心的研究目标 提供高质量、临床注释的黑色素瘤生物样本、人类和动物组织方面的专业知识 分析和尖端技术资源。 为了执行 NYULH 转移研究网络中心的中央科学战略，核心 B 将 1) 获取小鼠交叉验证所需的回顾性和前瞻性黑色素瘤患者样本 动物模型测试的数据和假设生成，2）完善尖端成像技术 多光谱免疫荧光分析，3) 提供术后病理评估的专业知识 实验小鼠和人体组织通过一个项目支持 3 个主要项目以及试点项目。 治理委员会，核心 B 还将利用生物样本的资源进行监督。 NYULH 黑色素瘤计划，包括最近授予的 SPORE，核心 B 将服务于 NYULH 转移研究网络中心社区以及网络的其他中心，避免重复 努力并最大限度地提高成本效益和效率。 总体而言，Core B 将提供高质量、带注释的黑色素瘤患者生物样本、尖端技术 为所有中心研究提供资源和病理学专业知识，以支持 NYULH 转移研究网络 该中心的使命是揭示黑色素瘤转移的决定因素，重点关注早期传播的驱动因素 以及与微环境成分的串扰。