Chronic graft-versus-host disease

慢性移植物抗宿主病

• 批准号: 10014723
• 负责人: Edward Cowen
• 金额: $ 132.61万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10014723
• 关键词: Calcinosis; Case Series; Clinical; Clinical Trials; Cutaneous; Functional disorder; Imatinib; Institutes; Output; Publications; Research Personnel; Risk Factors; Role; Skin; Skin Manifestations; Specialist; Specimen; United States National Institutes of Health; Whole-Body Irradiation; chronic graft versus host disease; multidisciplinary; novel; skin disorder

This effort continues to be very productive as evidenced by the yearly publication output related to GVHD, including publication of the Branch initiated imatinib clinical trial. In addition, I have made several important contributions to the identification of novel skin manifestations of cGVHD, as well as identified the role of total body irradiation as a risk factor for cGVHD. Current projects including ssRNA analysis of cutaneous GVHD specimens to better understand the pathophysiology of skin disease. Clinical projects including the first topical study of ruxolitinib for skin GVHD and a case series on cutaneous calcinosis in skin GVHD.

与GVHD有关的年度出版产出所证明的，这项工作仍然非常有生产力，包括发表该分支机构发起的伊马替尼临床试验。此外，我为鉴定CGVHD的新型皮肤表现做出了一些重要的贡献，并确定了全身照射为CGVHD的危险因素的作用。当前的项目包括皮肤GVHD标本的SSRNA分析，以更好地了解皮肤病的病理生理。临床项目，包括针对皮肤GVHD的首次鲁唑替尼的主题研究和皮肤GVHD皮肤钙化的病例系列。