Administrative Core

行政核心

基本信息

批准号：
10731711
负责人：
DENNIS J. HARTIGAN-O'CONNOR
金额：
$ 8.22万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-22 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10731711
关键词：
Address Administrator Anti-Retroviral Agents Antigens Award Chronic Clinical Trials Collaborations Communication Data Data Analyses Decision Making Disputes Elements Ensure Environment Fostering Funding Future Geography Goals Grant HIV HIV Infections HIV vaccine Human Human Resources Immune response Immune system Ingestion International Medicine National Institute of Allergy and Infectious Disease Online Systems Peer Review Pharmaceutical Preparations Process Program Research Project Grants Publications Reporting Research Resolution Resource Sharing Resources Sampling Scientist Specialist Structure T cell response Testing Therapeutic United States National Institutes of Health Vaccine Therapy Work cohort data management data sharing experience improved innovation mid-career faculty multidisciplinary multiple omics nonhuman primate novel strategies organizational structure programs somatic cell gene editing synergism

项目摘要

This Research Program Project, titled Omics signatures of transformative T-cell responses to therapeutic vaccination against HIV (OmiT-HIV), will use samples from human clinical trials and synergistic non-human primate studies to ask how therapeutic HIV vaccines can best elicit effective T- cell responses from the chronically infected and antigen-exposed host immune system. The Program has a strong multidisciplinary and international character, established by a team of expert PIs who are longstanding collaborators and have access to unique human cohorts and novel approaches to therapeutic vaccination of non-human primates. Such diversity, including geographic diversity, requires a strong administrative structure to promote synergy between the programmatic elements by facilitating regular, structured communication. This Administrative Core will provide overall organizational structure for the Program Project, perform administrative functions, interface with NIH/NIAID staff, foster cooperation between projects and with the Data Management and Analysis Core, encourage criticism and advice from its scientists and ESAB, promote fiscal responsibility, and assure the continued excellence of the Project and its ability to address the Specific Aims. The Administrative Core will be based at UC Davis and led by Dr. Hartigan-O’Connor, one of the project’s two MPIs. Dr. Hartigan-O’Connor previously led the administrative core for the RETIRE-HIV P01 at UC Davis, which engaged many of the same personnel and performed similar functions. He is also co-PI of the large U42 grant funding the Nonhuman Primate Testing Center for the NIH’s Somatic Cell Genome Editing Consortium. Thus, Dr. Hartigan-O’Connor has abundant experience in management of large collaborative projects such as this. The Core’s organization is supplemented by administrators, specialists, the External Scientific Advisory Board, and an Internal Steering Committee. The specific aims of the Administrative Core are: 1. Provide an organizational and programmatic structure to promote scientific excellence. 2. Provide organizational and financial oversight and future planning, establish decision-making processes, set priorities, and resolve disputes 3. Ensure efficient data, information, and resource sharing.

该研究项目的标题为“变革性 T 细胞反应的组学特征” HIV 治疗性疫苗（OmiT-HIV）将使用人体临床试验的样本和协同非人类灵长类动物研究探讨治疗性 HIV 疫苗如何才能最好地引发有效的 T- 来自慢性感染和抗原暴露的宿主免疫系统的细胞反应。具有很强的多学科和国际化特征，由专家 PI 团队建立，他们长期合作者，可以接触到独特的人类群体和新颖的治疗方法非人类灵长类动物的疫苗接种需要强大的多样性，包括地理多样性。行政结构，通过促进定期、该行政核心将为组织提供总体组织结构。计划项目，履行行政职能，与 NIH/NIAID 工作人员联系，促进之间的合作项目以及数据管理和分析核心，鼓励科学家的批评和建议和 ESAB，促进财政责任，并确保项目的持续卓越性及其能力解决具体目标。行政核心将设在加州大学戴维斯分校，并由 Hartigan-O’Connor 博士领导，他是该项目的两名负责人之一 Hartigan-O’Connor 博士曾领导加州大学戴维斯分校 RETIRE-HIV P01 的行政核心工作。该公司雇用了许多相同的人员并履行类似的职能，他也是该大型公司的联合 PI。 U42 拨款资助 NIH 体细胞基因组编辑非人类灵长类动物测试中心因此，Hartigan-O’Connor博士在大型协作管理方面拥有丰富的经验。诸如此类的项目，核心组织由管理员、专家和外部人员进行补充。科学顾问委员会和内部指导委员会。行政核心的具体目标是： 1. 提供组织和计划结构以促进科学卓越。 2. 提供组织和财务监督以及未来规划，建立决策流程，制定确定优先事项并解决争议 3. 确保数据、信息和资源的高效共享。