MOIR - Administrative Core

MOIR - 行政核心

• 批准号: 10731662
• 负责人: Rafick Pierre Sekaly
• 金额: $ 9.62万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-03 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10731662
• 关键词: Adherence; Agreement; Applications Grants; Budgets; Clinical; Clinical Research; Collaborations; Communication; Communities; Data; Data Set; Data Storage and Retrieval; Databases; Deposition; Disputes; Ensure; Environment; Ethics; Fostering; Funding; Future; Goals; Grant; HIV; Human; Immunity; Immunology; Immunotherapy; Infrastructure; Institution; Institutional Review Boards; Intellectual Property; Laboratories; Lead; Leadership; Link; Machine Learning; Metabolic; Modeling; Postdoctoral Fellow; Productivity; Program Evaluation; Program Research Project Grants; Progress Reports; Property Rights; Recommendation; Regulatory Pathway; Reproducibility; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Role; Sampling; Students; Validation; Viral; Work; clinical research site; collaborative environment; community engagement; conflict resolution; data infrastructure; data management; data sharing; education resources; epigenomics; immunological intervention; innovation; material transfer agreement; meetings; member; microbiome; multiple omics; organizational structure; programs; synergism; timeline; tool; transcriptomics; web site

ABSTRACT – ADMINISTRATIVE CORE The Administrative core of the P01 program grant entitled “Multi-OMIcs identification and validation of mechanisms triggered by Immune interventions aimed at reducing the size of the replication competent Reservoir “ (Multiomics Immunity Reservoir- MOIR) will provide scientific, fiscal, and regulatory oversight for all components of the P01 program across the participating institutions and clinical sites. This P01 contains 3 Research Projects, an Administrative Core, and a Machine Learning and Modeling Core. The overall goal of the administrative core is to establish an organized research environment that will foster collaborative interactions between investigators, promote innovative research, and meet the key objectives of the P01. The administrative core will thrive to ensure that scientific work plans are performed according to the highest ethical standards and follow the most stringent principles of rigor and reproducibility. The Administrative core will accomplish these goals through the following three specific aims: 1) Create an infrastructure plan for the overall management and coordination of the P01 activities; 2) Provide scientific and fiscal oversight, and generate annual progress reports to ensure that the P01 is in compliance with the stated milestones and timelines; and 3) Facilitate effective communication and foster productive interactions among Projects and Cores. The organizational infrastructure of the Administration core consists of an Administration Core Council (ACC), a scientific steering committee (SC), and a Scientific Advisory Board (SAB). The members of the SC (project and core leaders) will be responsible for scientific oversight, evaluation of program activities, ethical, scientific integrity and regulatory oversight. The ACC members, which consist of the Project and Core Lead PIs of the P01 and the program manager, will coordinate the highly integrative scientific agenda, provide financial oversight, manage data storage and data sharing among the scientific and lay community and establish a centralized website to facilitate communication both within and outside the P01 community. To facilitate interactions between PIs, postdoctoral fellows, students, and research support staff, the administrative core will organize monthly and annual meetings to discuss scientific progress and program activities. In addition, the administrative team will ensure the proper execution and adherence to all contractual agreements (MTA and IRBs) associated with the P01. Together the ACC and SC will serve to maximize the synergy between projects and cores, promote community engagement, assist in resolving conflicts and disputes, and implement a strategic approach to accomplish the Program goals.

摘要 - 行政核心 P01计划授予的行政核心名为“多派标识和验证 旨在减少复制大小的免疫干预措施触发的机制 水库“（多构疫苗储量 - 莫尔）将为所有人提供科学，财政和监管监督 参与机构和临床场所的P01计划的组成部分。这个p01包含3 研究项目，行政核心以及机器学习和建模核心。总体目标 行政核心是建立有组织的研究环境，以促进协作互动 在研究人员之间，促进创新研究并符合P01的关键对象。行政 核心将蓬勃发展，以确保根据最高道德标准执行科学工作计划 遵循最严格和可重复性的最严格原则。行政核心将完成这些 通过以下三个特定目标进行目标：1）为整体管理制定基础架构计划 和P01活动的协调； 2）提供科学和财政监督，并产生年度 进度报告以确保P01符合既定的里程碑和时间表；和 3）促进项目和核心之间有效的沟通并促进富有成效的互动。这 行政核心的组织基础设施由行政核心委员会（ACC）组成 科学指导委员会（SC）和科学顾问委员会（SAB）。 SC的成员（项目和 核心领导者）将负责科学监督，计划活动的评估，道德，科学 诚信和监管监督。 ACC成员，由项目和核心铅PI组成 P01和计划经理将协调高度集成的科学议程，提供财务 监督，管理数据存储和科学和外行社区之间的数据共享，并建立一个 集中网站，以促进P01社区内外的通信。促进 PI，博士后研究员，学生和研究支持人员之间的互动，行政核心将 组织每月和年度会议，讨论科学进步和计划活动。另外， 行政团队将确保适当执行和遵守所有合同协议（MTA和 IRB）与P01相关。 ACC和SC一起将有助于最大化项目之间的协同作用 以及核心，促进社区参与，协助解决冲突和争议，并实施战略 实现计划目标的方法。