Emory/Georgia TB Research Advancement Center (TRAC)

埃默里/佐治亚州结核病研究促进中心 (TRAC)

基本信息

批准号：
10429404
负责人：
Rafick Pierre Sekaly
金额：
$ 19.73万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-23 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10429404
关键词：
ATAC-seq Address Area Basic Science Bioinformatics Biological Assay Biological Markers Cells Cellular Indexing of Transcriptomes and Epitopes by Sequencing Clinical Clinical Sciences Communicable Diseases Communities Complex Computational Biology Computer Models Consult Consultations Core Facility Data Data Analyses Data Set Development Diagnosis Disease Disease Progression Doctor of Philosophy Education Educational workshop Environment Experimental Designs Faculty Flow Cytometry Fostering Functional disorder Funding Genes Genomics Immune Evasion Immunity Immunology Immunology procedure Individual Infrastructure Institution Intake Interdisciplinary Study Investigation Knowledge Laboratories Lead Leadership Measurement Mentorship Metabolic Pathway Methods Modeling Multiomic Data Pathway Analysis Postdoctoral Fellow Prevention Records Research Research Design Research Personnel Research Training Resolution Resource Sharing Resources Services Structure System Systems Biology Technology Tissues Training Translational Research Tuberculosis United States National Institutes of Health World Health Organization computational pipelines cytokine data acquisition data integration education resources epigenomics experimental study graduate student high dimensionality innovation lipidome lipidomics member metabolic phenotype metabolome metabolomics microbiome analysis multidimensional data multiple omics multiscale data next generation novel single cell technology tool transcriptome sequencing transcriptomics uptake

项目摘要

The Bioinformatics and Integrated Systems Biology (Systems Biology) Core will represent an integral component of the Emory/Georgia TRAC. While individual members of the Emory/Georgia TB research community have strong records of collaborative TB research, access to cutting edge methods in systems biology have not been easily accessible. Although the partner institutions of the Emory/Georgia TRAC host a wide variety of Core facilities performing ‘-omics’ assays, expertise in computational biology needed to analyze and integrate the high-dimensional, multiscale data sets produced by these platforms is often not readily available. We propose to provide essential support for high-dimensional, multiscale data analysis and integration to facilitate use of ‘-omics’ technologies among Emory/Georgia TRAC investigators. The Systems Biology Core will accomplish this by serving as a single point of contact (concierge function) to investigators of the Emory/Georgia TRAC, and facilitating access to a wide array of ‘-omics’ technologies for specific experimental designs. Using established computational pipelines, we will provide training to new investigators on methods in high-dimensional data analysis and data integration in this increasingly essential area of basic and translational research. The specific aims of the BISB Core are: 1) to provide a single point of contact structure for data acquisition, management, and analysis for all ‘-omics’ platforms to TRAC investigators; 2) To provide training and educational resources to TRAC members to carry out cutting edge experiments using ‘- omics’ technologies and implement associated computational pipelines; and 3) to develop and implement novel multiomics assays and associated computational models to advance TB research. We will strive to nurture a collaborative research environment among Emory/Georgia TRAC investigators by facilitating the use and implementation of cutting edge multiomics assays to advance TB research and train the next generation of TB researchers.

生物信息学和集成系统生物学（系统生物学）核心将代表不可或缺的 Emory/Georgia Trac的组成部分。而埃默里/佐治亚州结核病研究的个人成员社区有协作结核病研究的强大记录，系统中获得最先进方法的记录生物学不容易获得。尽管Emory/Georgia Trac的合作机构主持了A 进行“ - 组”评估的各种核心设施，分析所需的计算生物学专业知识并整合这些平台生产的高维，多尺度数据集通常不容易可用的。我们建议为高维，多尺度数据分析和集成以促进Emory/Georgia TRAC研究人员中使用“ -omics”技术。系统生物学核心将通过作为单个接触点（礼宾功能）来实现这一目标 Emory/Georgia Trac，并支持访问广泛的特定“ - 组”技术实验设计。使用既定的计算管道，我们将向新调查人员提供培训关于基本越来越重要领域的高维数据分析和数据集成的方法并翻译研究。 BISB核心的具体目的是：1）提供单个接触点为TRAC调查人员提供所有“ - 组”平台的数据获取，管理和分析的结构； 2）到向TRAC成员提供培训和教育资源，以使用' - OMICS的技术并实施相关的计算管道； 3）开发和实施新型的多层分析和相关的计算模型，以推进结核病研究。我们将努力护理Emory/Georgia Trac调查人员之间的协作研究环境以及实施最先进的多组学测定法以推进结核病研究并培训下一代结核病研究人员。