Development of New Technologies at Roswell Park to Further Cancer-Based Research and Treatment Through Genome Modification

罗斯威尔公园开发新技术，通过基因组修饰进一步开展基于癌症的研究和治疗

• 批准号: 10733275
• 负责人: Aimee B Stablewski
• 金额: $ 32.49万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733275
• 关键词: Animal Model; Applications Grants; Area; Biology; Cancer Center; Cancer Center Support Grant; Cell Line; Cells; Collaborations; Comprehensive Cancer Center; Consult; Consultations; Dedications; Development; Developmental Therapeutics Program; Doctor of Philosophy; Ensure; Funding; Gene Targeting; Genetic; Genetically Modified Animals; Genome; Grant; Infrastructure; Investments; Laboratories; Malignant Neoplasms; Modification; Positioning Attribute; Principal Investigator; Privatization; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Scientist; Specialist; Stress; Technology; Transgenic Organisms; United States National Institutes of Health; Wages; base; cancer research center director; career; experience; genome editing; member; neoplasm immunotherapy; new technology; programs; tool; tumor immunology

Abstract The current application seeks salary support for Aimee Stablewski, PhD who serves as the Director of the Gene Targeting and Transgenic Shared Resource (GeTT) of Roswell Park Comprehensive Cancer Center (Roswell Park). This position was created in 1999 to oversee the research applications of the various genome editing platforms available in the resource and to apply her extensive experience in these areas in collaborations and consultations with the GeTT investigator user base. With over 25 years of experience in research applications of the creation of genetically modified animals and cells (23 years at Roswell Park), Dr. Stablewski throughout her career has collaborated with many investigators at the Cancer Center on NIH funded projects. The GeTT is an integral part of Roswell Park's Cancer Center Support grant (P30CA016056) for which the cancer center Director, Dr. Johnson, serves as the Principal Investigator. All three CCSG programs (Developmental Therapeutics (DT), Tumor Immunology and Immunotherapy (TII) and Cancer Stress Biology (CSB) equally make up the user base of the GeTT; and numerous NIH-funded researchers in these programs actively collaborate and consult with Dr. Stablewski. Dr. Stablewski' s contributions to Roswell Parks research enterprise have been significant and impactful specifically with regards to the NIH-funded research of the members of the TII program. As of September 2022, there are thirty-nine grant applications that cited use of the GeTT shared resources. There were twenty-six NIH/ NCI, two DOD, and the remaining applications include private and public funding sponsors, eleven of whom were TII Program members, fourteen are CSB members and nine are DT members. The cancer center has also made significant investments in the GeTT with regards to advancing technology in genetic modifications. With the changes in the R50 program now making the distinction between Laboratory (PAR-20-288) and Core (PAR-20-287) based scientists and with the GeTT being an integral part of the Roswell Park CCSG infrastructure, Dr. Johnson as the PI of the CCSG grant, will now serve as the Unit Director for the application.

抽象的 当前申请寻求薪资支持Aimee Stablewski，博士，担任主任 罗斯威尔公园综合癌症中心的基因靶向和转基因共享资源（GETT） （罗斯威尔公园）。该立场是在1999年创建的，目的是监督各种基因组的研究应用 资源中可用的编辑平台，并在这些领域中运用她丰富的经验 与GETT调查员用户群的协作和咨询。拥有超过25年的经验 创建转基因动物和细胞的研究应用（罗斯威尔公园23年），博士 Stablewski在她的整个职业生涯中都与NIH癌症中心的许多调查员合作 资助的项目。 Gett是Roswell Park癌症中心支持补助金的组成部分（P3SCA016056） 癌症中心主任约翰逊博士担任首席研究员。这三个CCSG 计划（发育疗法（DT），肿瘤免疫学和免疫疗法（TII）和癌症压力 生物学（CSB）平均构成了Gett的用户群；以及许多NIH资助的研究人员 计划积极合作并与Stablewski博士进行协商。 Stablewski博士对罗斯威尔公园的贡献 研究企业在NIH资助的研究方面具有重要的影响力 TII计划的成员。截至2022年9月，有39个赠款申请引用了使用 GETT共享资源。有二十六个NIH/ NCI，两个DOD和其余的应用 包括私人和公共资助赞助商，其中11名是TII计划成员，14名是CSB 成员和九个是DT成员。 癌症中心还在推进技术方面对Gett进行了大量投资 遗传修饰。随着R50计划的变化现在使实验室之间的区别 （PAR-20-288）和Core（Par-20-287）科学家，而Gett是不可或缺的一部分 罗斯威尔公园CCSG基础设施，约翰逊博士担任CCSG Grant的PI，现在将担任该单位 申请主任。