Clinical Core D

临床核心D

• 批准号: 10397172
• 负责人: Jordan E Lake
• 金额: $ 19.67万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-23 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10397172
• 关键词: Acquired Immunodeficiency Syndrome; Acute; Age-Years; Basic Science; Bioinformatics; Biomedical Research; Biometry; Biostatistics Core; Blood specimen; Client; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Consultations; Data; Data Analyses; Data Analytics; Data Collection; Development; Doctor of Philosophy; Ensure; Epidemic; Evaluation; Faculty; Female; Formulation; Foundations; Funding; Goals; HIV; HIV Seronegativity; HIV prevention trials network; Health; Health Sciences; Health Services Research; Home; Human; Institution; Jordan; Knowledge; Leadership; Medical center; Medicine; Mentors; Mentorship; Patient Recruitments; Persons; Policies; Population; Population Research; Positioning Attribute; Procedures; Process; Research; Research Design; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Respondent; Risk; Sampling; Services; Site; Solid; Specimen; Strategic Planning; Surveys; Texas; Tissue Sample; Translational Research; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; base; biobank; career; cohort; college; data management; design; experience; high risk; human tissue; interest; meetings; next generation; nonhuman primate; patient population; pre-exposure prophylaxis; recruit; repository; response; success; tool development; transgender

PROJECT SUMMARY – CLINICAL AND BIOSTATISTICS CORE D The Texas Developmental Center for AIDS Research (D-CFAR) is based at Baylor College of Medicine (Baylor) and University of Texas Health Science Center at Houston (UTHealth) and the Texas Biomedical Research Institute (TxBiomed) in San Antonio. A strategic planning process demonstrated need for clinical and biostatitistical research support among both established and early stage investigators at the home institutions. The Texas D-CFAR will therefore establish a Clinical and Biostatistics Core (CBC, Core D) to capiltalize on the resources and expertise of HIV investigators and biostatisticians to facilitate high-impact clinical, translational and basic science research aimed at Ending HIV and Optimizing HIV Health in Texas. The Core leadership team has extensive experience in study design, clinical research, and research implementation, and data management and analysis. It also is well connected with national biobanks and repositories and is thus positioned to reach and support a diverse array of investigators. Texas D-CFAR investigators and affiliated users, whether junior or new to HIV research or the participating institutions, may lack knowledge of how to design, initiate and implement studies; how to obtain or access clinical samples or data; and/or how to design and execute appropriate and reliable data management and analytic plans. The CBC goal is to fill that gap. To do this, Core D will provide project development and implementation services for investigators who are junior or new to HIV research or D-CFAR institutions; provide access to human tissue and blood samples, facilitating clinical, translational and basic science research; and provide data analysis, data management and consultative biostatistical services to investigators who are junior or new to HIV research or D-CFAR institutions. The D-CFAR CBC will stimulate through mentorship and recruitment and facilitate through project implementation high-impact research, meeting the current and anticipated clinical, translational and basic science research and educational needs of local investigators, the NIH and our local communities of people with and at risk for HIV. The Core leadership, in collaboration with the D-CFAR leadership, has identified a comprehensive action plan, set of activities, policies and procedures and evaluation metrics to ensure success. Through accomplishing our aims, we will move toward our goal of Ending HIV and Optimizing HIV Health in Texas and be able to transition to full CFAR funding in 5 years.

项目摘要 – 临床和生物统计学核心 D 德克萨斯州艾滋病研究发展中心 (D-CFAR) 位于贝勒医学院 （贝勒）和德克萨斯大学休斯顿健康科学中心 (UTHealth) 和德克萨斯生物医学中心 位于圣安东尼奥的研究所 (TxBiomed) 的战略规划过程证明了对临床和治疗的需求。 为本国机构的成熟和早期研究人员提供生物统计研究支持。 因此，德克萨斯州 D-CFAR 将建立临床和生物统计学核心（CBC，核心 D）以利用 HIV 研究人员和生物统计学家的资源和专业知识，以促进高影响力的临床、转化 旨在消除德克萨斯州艾滋病毒和优化艾滋病毒健康的基础科学研究。 团队在研究设计、临床研究、研究实施和数据方面拥有丰富的经验 它还与国家生物库和存储库有良好的联系，因此 德克萨斯州 D-CFAR 调查员及附属机构 用户，无论是艾滋病毒研究或参与机构的初级或新手，可能缺乏如何 设计、启动和实施研究；如何获取或访问临床样本或数据和/或如何设计； CBC 的目标是填补这一空白。 为此，Core D 将为初级研究人员提供项目开发和实施服务 或 HIV 研究或 D-CFAR 机构的新手；提供人体组织和血液样本的获取，促进 临床、转化和基础科学研究；并提供数据分析、数据管理和 为 HIV 研究或 D-CFAR 初级或新手的研究人员提供生物统计咨询服务 D-CFAR CBC 将通过指导和招聘进行激励，并通过项目提供便利。 实施高影响力的研究，满足当前和预期的临床、转化和基础 当地研究人员、美国国立卫生研究院 (NIH) 和当地社区的科学研究和教育需求 核心领导层与 D-CFAR 领导层合作，确定了感染艾滋病毒和面临感染艾滋病毒风险的人群。 全面的行动计划、一系列活动、政策和程序以及评估指标，以确保成功。 通过实现我们的目标，我们将朝着消除艾滋病毒和优化艾滋病毒健康的目标迈进。 德克萨斯州能够在 5 年内过渡到全额 CFAR 资助。