Engaging Young People who Inject Drugs into HCV and HIV Care

让注射毒品的年轻人参与丙型肝炎和艾滋病毒护理

• 批准号: 10392902
• 负责人: Sabrina A Assoumou
• 金额: $ 18.15万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392902
• 关键词: Acquired Immunodeficiency Syndrome; Acute; Address; Affect; Age-Years; Boston; Caring; Case Management; Client; Clinical; Clinical Trials; Communicable Diseases; Continuity of Patient Care; Data Set; Development; Development Plans; Disease Outbreaks; Drug Metabolic Detoxication; Environment; Epidemic; Evidence based intervention; Faculty; Feasibility Studies; Fellowship; Foundations; Funding; Future; Goals; HIV; HIV diagnosis; HIV/HCV; Health Personnel; Healthcare Systems; Hepatitis C; Hepatitis C Therapy; Hepatitis C virus; Hospitals; Human immunodeficiency virus test; Indiana; Individual; Infection; Injecting drug user; Institute of Medicine (U.S.); Internal Medicine; Intervention; Interview; Israel; Learning; Link; Location; Medical center; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Modeling; Newly Diagnosed; Outcome; Patients; Pediatrics; Persons; Pharmaceutical Preparations; Phase; Pilot Projects; Population; Preparation; Prevention; Procedures; Publications; Publishing; Qualitative Research; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Resources; Scientist; Self Efficacy; Social Work; Statistical Methods; Target Populations; Techniques; Testing; Training; Twin Multiple Birth; United States; United States National Institutes of Health; Universities; Vulnerable Populations; Work; World Health Organization; acceptability and feasibility; addiction; aged; base; career; career development; cost effectiveness; design; drug testing; effective therapy; evidence base; experience; health care availability; health care delivery; implementation intervention; improved; improved outcome; injection drug use; innovation; medical schools; meetings; pilot test; prevention service; programs; skills; substance use; substance use treatment; success; therapy development; transmission process; treatment services; young adult

PROJECT SUMMARY / ABSTRACT Background: Recent human immunodeficiency virus (HIV) and hepatitis C virus (HCV) outbreaks, including the one in Indiana, illustrate that these infections should be addressed simultaneously to improve outcomes. In the United States most of the new HCV infections are among young people who inject drugs (PWID). Studies at detoxification centers have shown that linkage to care is problematic. Social services support such as case management has the potential to improve linkage to care; however, little is known about its potential influence on the care of young PWID. Candidate: I am a clinician scientist trained in combined internal medicine/pediatrics and infectious diseases (ID). I am committed to investigating strategies to improve health care delivery to HCV- and HIV-infected individuals. After completing an ID fellowship at Harvard's Beth Israel Deaconess Medical Center, I joined the faculty at Boston University (BU) School of Medicine, where I have gained experience working with substance using patients. I am applying for a 5-year K23 award to acquire the necessary skills and experience to become an independently funded clinician investigator with expertise to design, implement and analyze clinical interventions. Research: I will use the ADAPT-ITT framework to modify strengths-based case management (SBCM), an evidence-based linkage to care intervention, to address the needs of PWID aged 18 to 30 tested for HCV and HIV at a detoxification center. I will then pilot test the adapted intervention. The specific aims are to (1) To use in-depth, qualitative interviews to identify facilitators and barriers to linkage and retention in HIV and/or HCV care; (2) To use findings from Aim 1 to adapt SBCM to improve linkage and retention in care; 3) To conduct a feasibility study of the adapted intervention in preparation for a future trial. Training: The career development plan includes training in the development of interventions, clinical trials, advanced statistical methods, and substance use research. The BU ID department, the Centers for AIDS Research (CFAR) and the NIH-funded Learning for Early Careers in Addiction and Diversity program provide a rich research environment. Mentorship: My primary mentor, Dr. Samet, has expertise in substance use, HIV and HCV. Dr. Linas, my co-mentor, has expertise in HCV, HIV and linkage to care. Advisors are Drs. Bernstein (qualitative research), Horsburgh (HCV and HIV) and Sorensen (substance use and HIV). At the completion of my K23, I will have gained the skills necessary to become an independent clinician investigator focusing on HCV and HIV linkage to care among individuals with a history of substance use.

项目摘要 /摘要 背景：最近的人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）暴发，包括 印第安纳州的一个说明，应同时解决这些感染以改善结果。在 美国大多数新的HCV感染都是注射毒品的年轻人（PWID）。研究 在排毒中心，与护理的联系是有问题的。社会服务支持诸如案件 管理层有可能改善护理的联系；但是，对它的潜在影响知之甚少 在年轻的PWID的照顾下。候选人：我是一名临床医生，接受了内部联合培训 医学/儿科和传染病（ID）。我致力于调查改善健康的策略 护理给HCV和HIV感染的人。在哈佛的贝丝以色列完成ID奖学金之后 执事医疗中心，我加入了波士顿大学（BU）医学院的教职员工 获得了使用患者使用物质的经验。我正在申请5年K23奖励以获取 必要的技能和经验，成为一名具有专业知识的独立资助的临床研究者 设计，实施和分析临床干预措施。研究：我将使用Adapt-Itt框架修改 基于优势的案例管理（SBCM），是基于证据的护理干预措施的联系，以解决 在排毒中心对HCV和HIV测试的18至30岁的PWID的需求。然后，我将试行测试 改编干预措施。具体目的是（1）使用深入的定性访谈来确定促进者 以及在艾滋病毒和/或HCV护理中连接和保留的障碍； （2）使用AIM 1的调查结果将SBCM调整为 改善关联和保留的护理； 3）进行适应性干预的可行性研究 为将来的试验做准备。培训：职业发展计划包括开发的培训 干预措施，临床试验，先进的统计方法和药物使用研究。 BU ID部门， 艾滋病研究中心（CFAR）和NIH资助的成瘾和职业的NIH资助 多样性计划提供了丰富的研究环境。指导：我的主要导师Samet博士有 艾滋病毒和HCV的药物使用方面的专业知识。我的院长Linas博士在HCV，HIV和联系方面具有专业知识 关心。顾问是Drs。 Bernstein（定性研究），Horsburgh（HCV和HIV）和Sorensen（物质 使用和艾滋病毒）。在我的K23完成时，我将获得成为独立的必要技能 关注HCV和HIV联系的临床医生研究者与具有物质史的个体的护理 使用。

项目成果

Development and Validation of the HIV-CARDIO-PREDICT Score to Estimate the Risk of Cardiovascular Events in HIV-Infected Patients.

• DOI: 10.3390/cells12040523
• 发表时间: 2023-02-05
• 期刊: CELLS
• 影响因子: 6
• 作者: Karanika, Styliani;Karantanos, Theodoros;Carneiro, Herman;Assoumou, Sabrina A.
• 通讯作者: Assoumou, Sabrina A.

Sexually Transmitted and Blood-borne Infections Among Patients Presenting to a Low-barrier Substance Use Disorder Medication Clinic.

• DOI: 10.1097/adm.0000000000000801
• 发表时间: 2021-11-01
• 期刊: Journal of addiction medicine
• 影响因子: 5.5
• 作者: Harvey L;Taylor JL;Assoumou SA;Kehoe J;Schechter-Perkins EM;Bernstein E;Walley AY
• 通讯作者: Walley AY