Organization and architecture of a Center for cellular resolution analysis of Alzheimer's disease

阿尔茨海默病细胞分辨率分析中心的组织和架构

• 批准号: 10375358
• 负责人: Ed Lein
• 金额: $ 42.44万
• 依托单位: ALLEN INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10375358
• 关键词: Achievement; Adherence; Adopted; Adoption; Advisory Committees; Alzheimer' s Disease; Alzheimer' s disease pathology; Architecture; Authorship; Brain; Budgets; Cells; Collaborations; Communication; Communities; Computer software; Data; Data Analyses; Ensure; Epigenetic Process; Feedback; Fostering; Generations; Goals; Health; Individual; Industry; Infrastructure; Institutes; Institution; Joints; Leadership; Manuscripts; Molecular; Monitor; Pathogenesis; Performance; Phase; Procedures; Process; Production; Progress Reports; Publications; Quality Control; Reporting; Research; Research Personnel; Research Project Grants; Resolution; Resources; Risk Management; Role; Science; Site; Software Tools; Standardization; Strategic Planning; Structure; Supervision; Technology; Time; Universities; Visualization; Washington; cell type; cohesion; computerized data processing; conflict resolution; data exchange; data integration; data mining; data quality; data resource; data sharing; data standards; design; epigenomics; experience; hackathon; member; neuropathology; organizational structure; programs; software development; tool; transcriptomics; web portal; working group

ABSTRACT (ADMIN CORE) The Center proposal “A platform for cell type-level transcriptomic, epigenomic and spatial interrogation of Alzheimer’s disease” proposal aims to combine expertise in AD pathology with expertise in new single cell molecular technologies to generate a new high resolution cellular and molecular understanding of the early pathogenesis of AD. The Center consists of three Research Projects, focusing on neuropathology, transcriptomics and epigenomics, and spatial transcriptomics; a Data Core, and an Administrative Core with seven PIs and three collaborative sites. Realizing the potential of this Center requires strong administrative leadership to integrate and synergize efforts across the collaborating researchers at the University of Washington, Kaiser/Group Health and the Allen Institute for Brain Science. The Administrative Core will provide the structure, leadership and operational management of the Center towards achievement of the overall Center goals to understand the cellular and molecular basis of the early pathogenesis of AD. This will include project management, strategic planning, progress reporting, fiscal management, and support for collaboration and communication. The Administrative Core will create an infrastructure that fosters communication and collaboration among the Center members, as well as garnering input from the external AD research community through the formation of an External Scientific Advisory committee. The Center will form a Steering Committee and Project Teams to oversee the collaborative, standardized, and on-time data generation, data analysis, and public data sharing process. Project management best practices, such as milestones, progress reporting and tracking, collaborative software programs, and a responsibility matrix will be applied to the Center to ensure achievement of performance objectives and milestones, optimized communication, and resource utilization and prioritization. In addition, the Core will foster joint data analysis efforts across projects and Institutions, including joint Analysis Working Groups and hackathons. Further, the Administrative Core will support the implementation of standard operating procedures and quality control standards for data generation, data processing, and analysis. To produce a high-quality data resource for high resolution neuropathological and omics analysis of Alzheimer’s disease, rigorous standardization and quality control practices will be adopted by all members. Finally, the Administrative Core will implement and maintain fiscal and subcontractor management processes for all members, manage publication and authorship decisions and conflict resolution. With the implementation of this entire infrastructure, we anticipate that this project and the resources it produces will have a broad and meaningful impact on gaining a deep molecular and cellular understanding of Alzheimer’s disease pathology and progression.

摘要（管理员核心） 中心提案“用于细胞类型级转录，表观基因组和空间询问的平台 阿尔茨海默氏病”的提案旨在将广告病理学专业知识与新单细胞的专业知识相结合 分子技术生成新的高分辨率细胞和分子理解 AD发病机理。该中心由三个研究项目组成，重点是神经病理学， 转录组学和表观基因组学以及空间转录组学；数据核心，以及具有的管理核心 七个PI和三个协作网站。意识到该中心的潜力需要强大的行政 在大学合作研究人员中整合和协同努力的领导才能 华盛顿，凯撒/集团健康和艾伦脑科学研究所。 行政核心将提供该中心的结构，领导和运营管理 实现总体中心目标，以了解早期的细胞和分子基础 AD发病机理。这将包括项目管理，战略规划，进度报告，财政 管理和支持协作和沟通。管理核心将创建一个 促进中心成员之间沟通和协作的基础设施以及获得 外部广告研究社区的输入通过形成外部科学咨询 委员会。该中心将组建一个指导委员会和项目团队，以监督合作伙伴 标准化以及准时数据生成，数据分析和公共数据共享过程。项目管理 最佳实践，例如里程碑，进度报告和跟踪，协作软件程序以及 责任矩阵将应用于中心，以确保绩效对象的实现和 里程碑，优化的通信以及资源利用和优先级。此外，核心将培养 跨项目和机构的联合数据分析工作，包括联合分析工作组和 黑客马拉松。此外，行政核心将支持标准操作程序的实施 以及数据生成，数据处理和分析的质量控制标准。产生高质量数据 高分辨率的神经病理学和奥症分析的资源，严格 所有成员将采用标准化和质量控制实践。最后，行政核心将 实施并维护所有成员的财政和分包商管理流程，管理出版物 以及作者的决策和解决冲突。随着整个基础架构的实施，我们 预计该项目及其生产的资源将对获得 对阿尔茨海默氏病病理学和进展的深层分子和细胞理解。