Center for 3D Imaging in Cancer Cell Biology

癌细胞生物学 3D 成像中心

• 批准号: 10375191
• 负责人: Denis Wirtz
• 金额: $ 4.67万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10375191
• 关键词: 3-Dimensional; Address; Administrative Coordination; Advisory Committees; Advocate; Architecture; Basic Science; Beds; Biomedical Research; Budgets; Cancer Biology; Cells; Cellular biology; Chemicals; Collaborations; Communication; Communities; Comprehensive Cancer Center; Computing Methodologies; Disease; Doctor of Medicine; Doctor of Philosophy; Documentation; Engineering; Ensure; Event; Faculty; Financial Support; Funding; Gene Expression; Goals; Human; Human Resources; Imaging technology; Individual; Infrastructure; Institutes; Institutional Review Boards; Lead; Leadership; Liver; Malignant Neoplasms; Mentors; Mission; Monitor; Occupational activity of managing finances; Oncology; Pancreas; Pathology; Patient-Focused Outcomes; Patients; Productivity; Progress Reports; Publications; Reporting; Research; Research Personnel; Role; Schedule; Schools; Strategic Planning; Testing; Three-Dimensional Imaging; Three-dimensional analysis; Time; TimeLine; Tissues; United States National Institutes of Health; Wood material; anticancer research; biophysical properties; cancer cell; cancer imaging; career; clinically relevant; experience; imaging modality; improved; innovation; materials science; medical schools; meetings; member; mid-career faculty; multidisciplinary; nanobiotechnology; next generation; outreach; pancreatic cancer cells; pre-clinical research; professor; skills; success; synergism; technology development; tumor; web site; 3-Dimensional; Address; Administrative Coordination; Advisory Committees; Advocate; Architecture; Basic Science; Beds; Biomedical Research; Budgets; Cancer Biology; Cells; Cellular biology; Chemicals; Collaborations; Communication; Communities; Comprehensive Cancer Center; Computing Methodologies; Disease; Doctor of Medicine; Doctor of Philosophy; Documentation; Engineering; Ensure; Event; Faculty; Financial Support; Funding; Gene Expression; Goals; Human; Human Resources; Imaging technology; Individual; Infrastructure; Institutes; Institutional Review Boards; Lead; Leadership; Liver; Malignant Neoplasms; Mentors; Mission; Monitor; Occupational activity of managing finances; Oncology; Pancreas; Pathology; Patient-Focused Outcomes; Patients; Productivity; Progress Reports; Publications; Reporting; Research; Research Personnel; Role; Schedule; Schools; Strategic Planning; Testing; Three-Dimensional Imaging; Three-dimensional analysis; Time; TimeLine; Tissues; United States National Institutes of Health; Wood material; anticancer research; biophysical properties; cancer cell; cancer imaging; career; clinically relevant; experience; imaging modality; improved; innovation; materials science; medical schools; meetings; member; mid-career faculty; multidisciplinary; nanobiotechnology; next generation; outreach; pancreatic cancer cells; pre-clinical research; professor; skills; success; synergism; technology development; tumor; web site

Administration and Coordination Core - Project Summary: The Johns Hopkins Center for 3D Multiscale Cancer Imaging will facilitate innovation in advanced imaging technologies that could be applied to fundamental basic and pre-clinical research problems in cancer biology. The mission of our Administrative and Coordination (A&C) Core is to ensure that the individual Research Units combine with synergy beyond the individual parts, to contribute to the CCBIR Network with strength beyond the individual Center, to integrate with the NCI and the cancer research community, and to be a partner with patient advocates to connect basic research with improved patient outcomes. The Center brings together preeminent faculty from eight departments housed in two schools (Medicine and Engineering), three JHU Centers and Institutes, and a spatial omic expert at Yale. This multidisciplinary perspective enables us to bring the latest experimental and computational methods to bear on the most clinically relevant aspects of cancer. Center leadership are tremendously excited about the impact of the proposed Center and this is evident in substantial technical, administrative, and financial support provided to our team through scientific cores, administrative support from the Provost's office and Dean's office, and over $1M in matching funds. The leadership of the Center is strongly committed to mentoring the next generation of leaders in cancer research including those traditionally underrepresented in biomedical research. Our JH Center includes two early-stage investigators (ESI) as critical co-Leads of the first Technology Development Unit (Dr. Ho and Dr. Wu). Our Administrative Core will ensure the successful execution of our ambitious mission directed by two aims. Aim 1: Scientific and Financial Management of the Center. Drs. Wirtz and Wood will have overall responsibility for the scientific and administrative leadership of the Center, with support from an experienced Project Manager. A Steering Committee including the Multiple PIs, the Unit Leads and co-Leads, and the Project Manager will meet monthly to discuss scientific progress, challenges, and budgetary issues. The A&C Core will refine and monitor budgets, allocating funds to each unit to achieve overall center goals. They will also take the lead on preparing timely reports to the NIH, the Hopkins IRB, and other oversight regulatory bodies. Aim 2: Communication and Review: External Advisory Panel (EAP), Internal Advisory Committee (IAC), Patient Advocates, and NCI. The Core will develop and ensure timely communications and documentation within the Center and across all Centers within the network. In addition, the Core will monitor timelines and milestones, and assign tasks to the unit leaders to assure that milestones are met. Oversight will be provided by an EAP and the NCI. The A&C will gather annual progress reports from the units, address any potential major changes in direction, and with patient advocates, guide how our research relates to patient needs. The Center progress will be tracked using standard metrics in place for large projects at Hopkins, covering four domains (staffing, fiscal, productivity, and infrastructure).

管理与协调核心 - 项目摘要： 约翰·霍普金斯（Johns Hopkins）3D多尺度癌症成像中心将促进高级成像的创新 可以应用于癌症生物学的基本基础和临床前研究问题的技术。 我们的行政和协调的使命（A＆C）核心是确保单个研究单位 与超越各个部分的协同作用相结合，以超越强度为CCBIR网络做出贡献 个人中心，与NCI和癌症研究界集成，并与患者成为合作伙伴 主张将基础研究与改善患者结局联系起来。中心汇集了杰出的 来自两所学校（医学和工程），三个JHU中心的八个部门的教师 研究所，耶鲁大学的空间OMIC专家。这个多学科的观点使我们能够带来最新的 实验和计算方法涉及癌症最相关的方面。中心 领导力对拟议中心的影响非常兴奋，这在实质性方面很明显 通过科学核心提供的技术，行政和财政支持，行政管理 教务长办公室和院长办公室的支持，以及超过100万美元的匹配资金。领导 中心强烈致力于指导癌症研究的下一代领导者，包括 传统上，生物医学研究中的人为不足。我们的JH中心包括两个早期调查员 （ESI）作为第一技术开发部门的关键共同领导者（Ho博士和Wu博士）。我们的行政核心 将确保成功执行我们雄心勃勃的任务，该任务由两个目标执行。目标1：科学和财务 中心管理。博士。 Wirtz和Wood将对科学和 在经验丰富的项目经理的支持下，该中心的行政领导。转向 包括多个PI，单位线索和共同领导者在内的委员会，项目经理将每月满足 讨论科学进步，挑战和预算问题。 A＆C核心将完善和监控预算， 将资金分配给每个单位以实现总体中心目标。他们还将领导及时准备 向NIH，霍普金斯IRB和其他监督监管机构报告。目标2：沟通和审查： 外部咨询小组（EAP），内部咨询委员会（IAC），患者拥护者和NCI。核心意愿 开发并确保中心内以及内部所有中心的及时通信和文档 网络。此外，核心将监视时间表和里程碑，并将任务分配给单位领导者 确保满足里程碑。 EAP和NCI将提供监督。 A＆C将每年聚集 来自单位的进度报告，解决方向上的任何潜在重大变化，并与患者拥护者有关 指导我们的研究与患者需求的关系。中心的进度将使用标准指标在 在霍普金斯（Hopkins）进行大型项目的地方，涵盖了四个领域（人员配备，财政，生产力和基础设施）。