Social Stress, Adiposity, and Breast Cancer

社会压力、肥胖和乳腺癌

• 批准号: 10379021
• 负责人: Jennifer Wright Bea
• 金额: $ 17.62万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-02 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10379021
• 关键词: Address; Adipose tissue; Biological Markers; Blood; Body Composition; Breast Cancer Prevention; Coupled; Development; Diagnosis; Functional disorder; Goals; Immune System Diseases; Incidence; Inflammatory; Literature; Malignant Neoplasms; Measures; Menopause; Metabolic dysfunction; Obesity; Pathway interactions; Population; Postmenopause; Prognostic Marker; Research Activity; Research Personnel; Resources; Risk Factors; Role; Stress; Training; Training Activity; Underrepresented Minority; United States; Visceral; Woman; advanced breast cancer; anticancer research; cancer prevention; carcinogenicity; cardiometabolism; career; design; malignant breast neoplasm; mortality; social relationships; social stress; subcutaneous

Project Summary Breast cancer persists as being the leading form of cancer among women in the United States (U.S.) with 1 in 8 women receiving the diagnosis in their lifetime. Body composition, notably visceral adipose tissue (VAT), is both a salient risk factor and prognostic indicator for breast cancer in post-menopausal women. Less is known about the role of subcutaneous adipose tissue (SAT) in breast cancer in this population. Accumulation of VAT coupled with menopause drives a pathophysiology of inflammatory, metabolic, and immunological dysfunction, measured by blood biomarkers, which are associated with cancer genesis. The role of social stress in the development of VAT is well established in the cardiometabolic literature. Yet, there is a paucity of literature on the intersection of social stress, body composition, and breast cancer. The specific aims of this Diversity Supplement are designed to address this critical gap in the breast cancer and body composition literature. These aims will: 1. Examine the relationship of social stress, adiposity types (VAT vs. SAT), and breast cancer incidence and mortality; 2. Examine the relationship of blood biomarkers and social stress to explore cancer promoting mechanisms of stress in post-menopausal women; 3. Provide training and professional development opportunities to Dr. Valencia, an underrepresented minority early-stage investigator. Through participation in the proposed research and training activities, Dr. Valencia will gain fundamental expertise in body composition, cancer promoting pathophysiological pathways, and social stress to help her achieve her ultimate career goals to continue to perform impactful cancer research.

项目摘要 乳腺癌一直是美国妇女（美国）中癌症的主要形式，其中1分之一 妇女一生接受诊断。身体成分，尤其是内脏脂肪组织（VAT），都是 绝经后妇女中乳腺癌的显着危险因素和预后指标。少知道 皮下脂肪组织（SAT）在该人群中的作用。增值税耦合的积累 更年期驱动炎症，代谢和免疫功能障碍的病理生理学，测量 由血液生物标志物与癌症起源相关。社会压力在发展中的作用 增值税在心脏代谢文献中已很好地确定。然而，关于交集的文献很少 社会压力，身体组成和乳腺癌。这种多样性补充的具体目的是设计的 解决乳腺癌和人体组成文献中的这一关键差距。这些目标将：1。检查 社会压力，肥胖类型（VAT与SAT）以及乳腺癌的发病率和死亡率的关系； 2。 检查血液生物标志物和社会压力的关系，以探索促进癌症的促进机制 绝经后妇女的压力； 3。为博士提供培训和专业发展机会。 瓦伦西亚（Valencia），一位代表性不足的少数族裔早期调查员。通过参与拟议的研究 和培训活动，瓦伦西亚博士将获得身体成分，癌症的基本专业知识 病理生理途径和社会压力，以帮助她实现她的最终职业目标 进行有影响力的癌症研究。