The Sylvester Cancer Center Support Grant

西尔维斯特癌症中心支持补助金

• 批准号: 9789579
• 负责人: Stephen D. Nimer
• 金额: $ 214.9万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-10 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9789579
• 关键词: Achievement; Address; Advanced Malignant Neoplasm; Affect; Argentina; Award; Basic Science; Behavioral Research; Bioinformatics; Biometry; Cancer Biology; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Research Program; Cancer Etiology; Cancer Patient; Caribbean region; Catchment Area; Clinical; Clinical Research; Clinical Sciences; Communities; Community Outreach; Competence; Comprehensive Cancer Center; County; Cultural Backgrounds; Cultural Diversity; Development; Diagnosis; Discipline; Education; Ensure; Environment; Environmental Risk Factor; Epigenetic Process; Extramural Activities; Florida; Flow Cytometry; Fostering; Funding; Future; Grant; Growth; Health Professional; Heterogeneity; Home environment; Human; Individual; Intervention; Investments; Knowledge; Latin America; Leadership; Learning; Malignant Neoplasms; Mission; National Cancer Institute; Outcome; Outreach Research; Patient Care; Patients; Peer Review; Play; Population Research; Population Sciences; Positioning Attribute; Prevention; Research; Research Infrastructure; Research Personnel; Resource Sharing; Rewards; Role; SECTM1 gene; Schools; Scientific Advances and Accomplishments; Scientist; Services; Source; Strategic Planning; Training; Training and Education; Translational Research; Translations; Tumor Biology; United States National Institutes of Health; Universities; anticancer research; base; bench to bedside; cancer genomics; cancer health disparity; cancer prevention; cancer risk; college; community based participatory research; community center; ethnic identity; ethnic minority population; health equity; innovation; insight; interest; multidisciplinary; novel; novel strategies; oncology; outreach; post-doctoral training; pre-doctoral; programs; racial and ethnic; recruit; research facility; socioeconomics

PROJECT SUMMARY: OVERALL The Sylvester Comprehensive Cancer Center (Sylvester) at the University of Miami seeks National Cancer Institute (NCI) designation to support its mission to reduce the human burden from cancer through research, education, prevention, and the delivery of quality patient care. Sylvester, the only academic Cancer Center located in South Florida, serves one of the most diverse catchment areas in the US. This four-county region (Broward, Miami-Dade, Monroe, and Palm Beach Counties), commonly known as South Florida, is home to more than six million residents and is characterized by substantial ethnic, cultural, racial, and socioeconomic diversity, reflected in the individuals treated by Sylvester and those affected by its outreach efforts. Led by Stephen D. Nimer, MD since 2012, Sylvester leadership has assembled a highly collaborative group of investigators that now includes 114 cancer scientists from three University Schools and Colleges. Sylvester’s research is organized into three Research Programs—Cancer Control, Cancer Epigenetics, and Tumor Biology. These programs are unified by crosscutting scientific themes and by Sylvester’s broader mission to address the cancer burden and disparities prevalent in its catchment area. Sylvester has invested heavily in these Research Programs and in four state-of-the-art shared resources that support Sylvester’s cancer researchers: the Biostatistics and Bioinformatics, Onco-Genomics, Flow Cytometry, and Behavioral and Community-Based Research Shared Resources. Sylvester has also invested heavily in its clinical research infrastructure, which has led to a dramatic increase in interventional treatment accruals (from 75 in 2011 to 509 in 2017), with more than 50% of the 4,568 patient accruals in 2017 representing racial/ethnic minorities. The University has made a substantial commitment to advancing Sylvester’s research capabilities since 2012, supporting the recruitment of 41 cancer researchers and doubling Cancer Center space. Sylvester has also expanded its pre- and post-doctoral training efforts across the clinical, basic, translational, and population sciences, which have been rewarded with five recently awarded NIH or NCI-funded T32 training grants, a U54 grant with a significant training component, and a Paul Calabresi K12 grant. Finally, Sylvester has invested roughly $5.7M in its Intramural Funding Program from 2014 to 2018, which has yielded $25.2M in peer-reviewed funding. Today, Sylvester has $38M in extramural research funding (including training grants), which includes $11M from the NCI; this represents a 12% and 64% increase, respectively, over the past year. These impressive achievements have created a culture and environment that enable Sylvester scientists to make valuable contributions to the understanding of cancer biology and the development of novel approaches to cancer prevention, diagnosis, and treatment.

项目概要：总体 迈阿密大学西尔维斯特综合癌症中心（西尔维斯特）寻求国家癌症 研究所 (NCI) 指定支持其通过研究减轻人类癌症负担的使命， 西尔维斯特是唯一的学术癌症中心。 位于南佛罗里达州，服务于美国最多元化的集水区之一。 （布劳沃德县、迈阿密戴德县、门罗县和棕榈滩县）通常称为南佛罗里达州，是 超过 600 万居民，具有显着的民族、文化、种族和社会经济特征 多样性，体现在西尔维斯特治疗的个人以及受其外展工作影响的人身上。 自 2012 年以来，Sylvester 领导层由医学博士 Stephen D. Nimer 领导，组建了一个高度协作的团队 研究人员目前包括来自三所西尔维斯特大学学院的 114 名癌症科学家。 研究分为三个研究项目——癌症控制、癌症表观遗传学和肿瘤 这些项目通过交叉的科学主题和西尔维斯特更广泛的使命来统一。 西尔维斯特已投入巨资解决其流域内普遍存在的癌症负担和差异。 这些研究项目和四个支持西尔维斯特癌症的最先进的共享资源 研究人员：生物统计学和生物信息学、肿瘤基因组学、流式细胞术以及行为和 基于社区的研究共享资源。 西尔维斯特还对其临床研究基础设施进行了大量投资，这导致了临床研究基础设施的大幅增长 介入治疗应计患者数（从 2011 年的 75 例增加到 2017 年的 509 例），占 4,568 名患者的 50% 以上 2017 年代表种族/族裔的应计项目做出了重大承诺。 自 2012 年起提升西尔维斯特的研究能力，支持招募 41 名癌症研究人员 西尔维斯特癌症中心的空间增加了一倍，还扩大了博士前和博士后培训工作。 涵盖临床、基础、转化和人口科学，最近获得了 5 项奖励 获得 NIH 或 NCI 资助的 T32 培训补助金、包含重要培训内容的 U54 补助金以及 Paul 最后，Sylvester 为其校内资助计划投资了约 570 万美元。 2014 年至 2018 年，已获得 2520 万美元的同行评审资金，如今，西尔维斯特拥有 3800 万美元的外部资金。 研究经费（包括培训补助金），其中包括来自 NCI 的 1100 万美元，占 12%； 较去年分别增长 64%。 这些令人印象深刻的成就创造了一种文化和环境，使西尔维斯特科学家能够 为理解癌症生物学和开发新方法做出宝贵贡献 到癌症的预防、诊断和治疗。