TR&D 2: Quantitative multi-contrast MRI at 3T and 7T.

TR

• 批准号: 9535306
• 负责人: Peter CM Van Zijl
• 金额: $ 18.26万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9535306
• 关键词: Aging; Alzheimer' s Disease; Amides; Amines; Amplifiers; Anatomy; Atlases; Attention deficit hyperactivity disorder; Autistic Disorder; Biological Markers; Brain; Brain Neoplasms; Brain imaging; Cerebrum; Chemicals; Child; Childhood; Clinical; Collaborations; Deformity; Development; Disease; Early Diagnosis; Evaluation; Feedback; Frequencies; Glutamates; Goals; Grant; Hour; Human; Huntington Disease; Hydroxyl Radical; Image; Laboratories; Lesion; Magnetic Resonance Imaging; Magnetism; Measurement; Measures; Metabolic; Metabolism; Methodology; Methods; Motion; Multiple Sclerosis; Necrosis; Neurodegenerative Disorders; Neurologic; Noise; Onset of illness; Outcome; Oxygen; Pathologic Processes; Patients; Perfusion; Phase; Physiologic pulse; Physiological; Physiology; Predisposition; Principal Investigator; Process; Protons; Radiation; Radiology Specialty; Recurrent tumor; Relaxation; Research; Resolution; Resources; Scanning; Schizophrenia; Signal Transduction; Speed; Technology; Technology Transfer; Testing; Time; Tissue imaging; Tissues; Venous; Water; base; brain tissue; cerebral blood volume; chemical group; chemotherapy; clinical imaging; contrast enhanced; design; disability; disease diagnosis; imaging approach; magnetic field; magnetic resonance imaging biomarker; metabolic rate; method development; mid-career faculty; nervous system disorder; novel; novel strategies; nuclear Overhauser enhancement; pediatric patients; professor; radiofrequency; tissue biomarkers; treatment effect

TR&D 2. Quantitative multi-contrast MRI at 3T and 7T. Principal investigators: Peter C.M. van Zijl, Professor of Radiology Hanzhang Lu, Associate Professor of Radiology SUMMARY The discovery of tissue biomarkers that can provide early and more specific information regarding physiological or metabolic changes can be seen as the holy grail of clinical imaging. The availability of such biomarkers is one of the main issues that we are continuously being inquired about by our collaborative projects (CPs), which study such topics as autism spectum disorder (ASD), pediatric brain development, Attention Deficit Hyperactivity Disorder (ADHD), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Huntington's Disease (HD), Schizophrenia (SCZ), and brain tumors. Our overall goal is therefore to develop MRI methodologies at 3T and 7T that can provide the quantitative biomarkers needed by our CPs. Towards this goal, AIM 1 is focused on the development of exchange transfer imaging (ETI) of the brain. Based originally on chemical exchange saturation transfer (CEST) MRI, which uses pulse sequences similar to conventional magnetization transfer MRI, ETI is broader as it allows the assessment of tissue metabolites that contain exchangeable protons using not only radiofrequency saturation, but instead pulsed excitation sequences that can be used to edit out specific tissue components based on their exchange rate or transverse relaxation time. In addition, we will exploit multi-transmit capabilities of the scanner to avoid amplifier duty cycle limitations on the human scanners. In AIM 2, we will develop methods to determine quantitative magnetic susceptibilities of tissue independent of the orientation of the brain. The purpose of Aim 3 is to design technology that allows assessment of both relative (changes in) and absolute arterial and arteriolar cerebral blood volume (CBVa), venous cerebral blood volume (CBVv), and cerebral metabolic rate of oxygen metabolism (CMRO2).

TR＆D 2。 3T和7T的定量多对比度MRI。 主要研究人员： 彼得C.M.放射学教授Van Zijl Hanzhang Lu，放射学副教授 概括 发现组织生物标志物可以提供有关早期和更具体信息的组织生物标志物 生理或代谢变化可以看作是临床成像的圣杯。可用性 这样的生物标志物是我们不断询问的主要问题之一 协作项目（CPS），研究自闭症幽灵障碍（ASD）等主题，小儿 大脑发育，注意力缺陷多动症（ADHD），阿尔茨海默氏病（AD）， 多发性硬化症（MS），亨廷顿氏病（HD），精神分裂症（SCZ）和脑肿瘤。我们的 因此，总体目标是在3T和7T处开发MRI方法论，以提供定量 我们的CPS所需的生物标志物。 为了实现这一目标，AIM 1专注于开发交换转移成像（ETI） 脑。最初基于使用脉冲的化学交换饱和转移（CEST）MRI 类似于常规磁化转移MRI，ETI的序列更广泛，因为它允许 评估包含可交换质子的组织代谢物，不仅使用射频 饱和，而是脉冲激发序列，可用于编辑特定组织 组件基于其汇率或横向松弛时间。此外，我们将利用 扫描仪的多交易功能以避免对人类的放大器占空比限制 扫描仪。在AIM 2中，我们将开发方法来确定 组织独立于大脑的方向。目标3的目的是设计技术 允许评估相对（变化）和绝对动脉和动脉脑血液 体积（CBVA），静脉脑血体积（CBVV）和氧气代谢率 代谢（CMRO2）。