Ohio State University Neuroscience Center Core

俄亥俄州立大学神经科学中心核心

基本信息

批准号：
9568035
负责人：
Anthony Brown
金额：
$ 46.08万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9568035
关键词：
Address Adoption Anxiety Area Award Basic Science Behavior Behavioral Brain Brain Injuries Brain Neoplasms Budgets Cancer Grant Supplements (P30)Cells Circadian Rhythms Clinical Collaborations Color Communication Communities Consult Consultations Contusions Core Facility Cultured Cells Data Analyses Electrophysiology (science)Embryo Ensure Environment Equilibrium Equipment Expenditure Experimental Designs Fluorescence Fluorescence Microscopy Fluorescence Resonance Energy Transfer Fostering Funding Group Meetings Health Services Accessibility Hospitals Human Resources Image Image Analysis Individual Injury Institutes Investments Joints Laboratories Learning Lesion Locomotor Recovery Memory Microinjections Microscope Modeling Monitor Mus National Institute of Neurological Disorders and Stroke Nervous System Trauma Neurodegenerative Disorders Neuroglia Neuromuscular Diseases Neurons Neurosciences Neurosciences Research Ohio Peer Review Peripheral nerve injury Phenotype Policies Procedures Productivity Progress Reports Protocols documentation Publications Qualifying Rattus Research Research Infrastructure Research Institute Research Personnel Research Project Grants Research Support Rodent Rodent Model Running Scanning Schedule Sensory Service delivery model Services Slice Speed Spinal Standardization Surgical Injuries Technical Expertise Technology Testing Time Tissues Toxin Training Translational Research Traumatic Brain Injury United States National Institutes of Health Universities Vertebral column Work Zebrafish behavior test behavioral study catalyst cost depressive symptoms equipment training experience experimental study flexibility fluorescence imaging high standard image processing interdisciplinary approach meetings nervous system disorder new technology novel strategies operation optogenetics photoactivation response skills spinal cord and brain injury

项目摘要

The Ohio State University (OSU) Neuroscience Center Core, now in its 12th year of NINDS support, provides specialized expertise and services that support research into the causes and treatments of neurological disorders. The Center serves a total of more than 40 neuroscientists (20 NINDS-funded) from multiple departments, centers, and institutes, and has become a catalyst for neuroscience research and collaboration across campus. Areas of strength include basic and translational research on neurodegenerative and neuromuscular diseases, brain tumors and neurotrauma. The Center leverages substantial institutional investment and federal support in research infrastructure and neuroscience at OSU. This includes the recently formed Brain and Spine Hospital and the Neuroscience Research Institute, a multi-million dollar effort that aligns the activities of about 175 basic and clinical neuroscientists across campus. The Center comprises one Administrative Core and four Scientific Cores, all of which are established, functional and successful. The Scientific Cores provide access to services, equipment and expertise not otherwise available to individual PIs, enhancing their ability to execute the aims of their funded projects and facilitating their adoption of new approaches and technologies. This centralization of expertise and equipment in the Scientific Cores increases the efficiency and quality of NINDS-funded research at OSU by minimizing duplication of effort and equipment, and ensuring the uniform application of best practices. The Cores are directed by investigators with deep and proven expertise in the Core services. Core A (Administrative) sets policies, oversees the Core operations and budget, and facilitates communication of Core services to neuroscientists on campus. The Core arranges meetings of the Neuroscience User Group in order to promote core services, identify new needs, and promote cross-core collaborations. Core B (Injury) provides equipment, training and technical expertise, including standardized and well-characterized injury protocols, to support research on spinal cord and brain injury models in rodents. Core C (Behavior) provides access to the equipment and skilled technical expertise necessary to perform comprehensive behavioral phenotyping of rodent models, as well as expert training and consultation on the execution of behavioral experiments. Core D (Electrophysiology) provides specialized equipment, training and technical expertise necessary to monitor and record the electrical activity of neurons and glia. Core E (Imaging) provides access to confocal microscopes including expert training, consultation and assistance with fluorescence imaging of living and fixed cells, tissues and embryos. Collectively these Cores will support 23 NINDS-funded projects (including 12 qualifying R01 projects) totaling $7.5 million dollars in annual funding, plus 14 other NIH-funded neuroscience projects totaling $3.9 million in annual funding, enhancing the research environment for these projects and fostering a cooperative and interactive research environment in which multi-disciplinary approaches and joint research efforts are stimulated.

俄亥俄州立大学 (OSU) 神经科学中心核心现已进入 NINDS 支持的第 12 个年头，提供支持神经系统疾病病因和治疗研究的专业知识和服务失调。该中心总共为来自多个国家的 40 多名神经科学家（其中 20 名由 NINDS 资助）提供服务。部门、中心和研究所，并已成为神经科学研究和合作的催化剂穿过校园。优势领域包括神经退行性疾病和神经退行性疾病的基础和转化研究神经肌肉疾病、脑肿瘤和神经外伤。该中心利用大量机构俄勒冈州立大学研究基础设施和神经科学的投资和联邦政府支持。这包括最近成立了脑与脊柱医院和神经科学研究所，耗资数百万美元协调校园内约 175 名基础和临床神经科学家的活动。该中心包括一行政核心和四个科学核心均已建立、正常运行且取得成功。这科学核心提供个人 PI 无法获得的服务、设备和专业知识，提高他们执行资助项目目标的能力，并促进他们采用新的方法和技术。科学核心中专业知识和设备的集中化增强了通过最大限度地减少工作和设备的重复，提高俄勒冈州立大学 NINDS 资助研究的效率和质量，并确保最佳实践的统一应用。核心由具有深厚知识的调查员指导核心服务方面经过验证的专业知识。核心 A（行政）制定政策，监督核心运营和预算，并促进核心服务与校园神经科学家的沟通。核心安排召开神经科学用户组会议，以促进核心服务、确定新需求并促进跨核心合作。核心 B（伤害）提供设备、培训和技术专业知识，包括标准化且特征明确的损伤方案，以支持脊髓和脑损伤的研究啮齿动物模型。核心 C（行为）提供对设备和熟练技术专业知识的访问对啮齿动物模型进行全面的行为表型分析以及专家培训和关于行为实验执行的咨询。核心D（电生理学）提供专门的监测和记录神经元电活动所需的设备、培训和技术专业知识和神经胶质细胞。 Core E（成像）提供共焦显微镜的使用，包括专家培训、咨询并协助活细胞和固定细胞、组织和胚胎的荧光成像。统称为这些核心将支持 23 个 NINDS 资助的项目（包括 12 个合格的 R01 项目），总额达 750 万美元年度资助，加上 NIH 资助的其他 14 个神经科学项目，年度资助总额为 390 万美元，改善这些项目的研究环境并促进合作和互动研究激发多学科方法和联合研究努力的环境。