Ohio State University Neuroscience Center Core

俄亥俄州立大学神经科学中心核心

基本信息

批准号：
9568035
负责人：
Anthony Brown
金额：
$ 46.08万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9568035
关键词：
Address Adoption Anxiety Area Award Basic Science Behavior Behavioral Brain Brain Injuries Brain Neoplasms Budgets Cancer Grant Supplements (P30)Cells Circadian Rhythms Clinical Collaborations Color Communication Communities Consult Consultations Contusions Core Facility Cultured Cells Data Analyses Electrophysiology (science)Embryo Ensure Environment Equilibrium Equipment Expenditure Experimental Designs Fluorescence Fluorescence Microscopy Fluorescence Resonance Energy Transfer Fostering Funding Group Meetings Health Services Accessibility Hospitals Human Resources Image Image Analysis Individual Injury Institutes Investments Joints Laboratories Learning Lesion Locomotor Recovery Memory Microinjections Microscope Modeling Monitor Mus National Institute of Neurological Disorders and Stroke Nervous System Trauma Neurodegenerative Disorders Neuroglia Neuromuscular Diseases Neurons Neurosciences Neurosciences Research Ohio Peer Review Peripheral nerve injury Phenotype Policies Procedures Productivity Progress Reports Protocols documentation Publications Qualifying Rattus Research Research Infrastructure Research Institute Research Personnel Research Project Grants Research Support Rodent Rodent Model Running Scanning Schedule Sensory Service delivery model Services Slice Speed Spinal Standardization Surgical Injuries Technical Expertise Technology Testing Time Tissues Toxin Training Translational Research Traumatic Brain Injury United States National Institutes of Health Universities Vertebral column Work Zebrafish behavior test behavioral study catalyst cost depressive symptoms equipment training experience experimental study flexibility fluorescence imaging high standard image processing interdisciplinary approach meetings nervous system disorder new technology novel strategies operation optogenetics photoactivation response skills spinal cord and brain injury

项目摘要

The Ohio State University (OSU) Neuroscience Center Core, now in its 12th year of NINDS support, provides specialized expertise and services that support research into the causes and treatments of neurological disorders. The Center serves a total of more than 40 neuroscientists (20 NINDS-funded) from multiple departments, centers, and institutes, and has become a catalyst for neuroscience research and collaboration across campus. Areas of strength include basic and translational research on neurodegenerative and neuromuscular diseases, brain tumors and neurotrauma. The Center leverages substantial institutional investment and federal support in research infrastructure and neuroscience at OSU. This includes the recently formed Brain and Spine Hospital and the Neuroscience Research Institute, a multi-million dollar effort that aligns the activities of about 175 basic and clinical neuroscientists across campus. The Center comprises one Administrative Core and four Scientific Cores, all of which are established, functional and successful. The Scientific Cores provide access to services, equipment and expertise not otherwise available to individual PIs, enhancing their ability to execute the aims of their funded projects and facilitating their adoption of new approaches and technologies. This centralization of expertise and equipment in the Scientific Cores increases the efficiency and quality of NINDS-funded research at OSU by minimizing duplication of effort and equipment, and ensuring the uniform application of best practices. The Cores are directed by investigators with deep and proven expertise in the Core services. Core A (Administrative) sets policies, oversees the Core operations and budget, and facilitates communication of Core services to neuroscientists on campus. The Core arranges meetings of the Neuroscience User Group in order to promote core services, identify new needs, and promote cross-core collaborations. Core B (Injury) provides equipment, training and technical expertise, including standardized and well-characterized injury protocols, to support research on spinal cord and brain injury models in rodents. Core C (Behavior) provides access to the equipment and skilled technical expertise necessary to perform comprehensive behavioral phenotyping of rodent models, as well as expert training and consultation on the execution of behavioral experiments. Core D (Electrophysiology) provides specialized equipment, training and technical expertise necessary to monitor and record the electrical activity of neurons and glia. Core E (Imaging) provides access to confocal microscopes including expert training, consultation and assistance with fluorescence imaging of living and fixed cells, tissues and embryos. Collectively these Cores will support 23 NINDS-funded projects (including 12 qualifying R01 projects) totaling $7.5 million dollars in annual funding, plus 14 other NIH-funded neuroscience projects totaling $3.9 million in annual funding, enhancing the research environment for these projects and fostering a cooperative and interactive research environment in which multi-disciplinary approaches and joint research efforts are stimulated.

俄亥俄州立大学（OSU）神经科学中心的核心（现已获得NINDS的12年）提供专门的专业知识和服务，支持对神经学的原因和治疗的研究疾病。该中心总共提供40多个来自多个的神经科学家（20 Ninds资助）部门，中心和机构，已成为神经科学研究与协作的催化剂整个校园。强度领域包括有关神经退行性和转化的基础研究和转化研究神经肌肉疾病，脑肿瘤和神经肿瘤。中心利用大量机构 OSU研究基础设施和神经科学的投资和联邦支持。这包括最近成立了大脑和脊柱医院以及神经科学研究所，这是一项数百万美元的努力整理校园中大约175名基本和临床神经科学家的活动。中心包括一个行政核心和四个科学核心，所有这些核心都是建立，功能和成功的。这科学核心提供了获得服务，设备和专业知识的访问增强他们执行其资助项目目标并促进新的新目标的能力方法和技术。科学核心中专业知识和设备的集中化增加了通过最大程度地减少努力和设备的重复，在OSU上资助的NINDS资助研究的效率和质量，并确保最佳实践的统一应用。核心是由具有深度和深处的调查员指导的在核心服务方面有经过验证的专业知识。核心A（管理）设定策略，监督核心操作和预算，并促进了校园内神经科学家的核心服务的沟通。核心安排神经科学用户组的会议，以促进核心服务，确定新需求并促进跨核协作。核心B（伤害）提供设备，培训和技术专长，包括标准化且特征良好的伤害方案，以支持脊髓和脑损伤的研究啮齿动物中的模型。 Core C（行为）提供了对设备和熟练技术专长的访问对啮齿动物模型以及专家培训和专家培训的全面行为表型的必要就行为实验的执行咨询。核心D（电生理学）提供专业设备，培训和技术专长，以监测和记录神经元的电活动和神经胶质。核心E（成像）提供了对共聚焦显微镜的访问，包括专家培训，咨询以及对生物和固定细胞，组织和胚胎的荧光成像的辅助。集体这些核心将支持23个由Ninds资助的项目（包括12个合格的R01项目），总计750万美元在年度资金中，加上其他14个NIH资助的神经科学项目，总计390万美元的年度资金，增强这些项目的研究环境并培养合作和互动研究刺激了多学科方法和联合研究工作的环境。