CARDIOVASCULAR CORE

心血管核心

• 批准号: 7638639
• 负责人: Douglas E Vaughan
• 金额: $ 25.66万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7638639
• 关键词: Aerobic; Animals; Atherosclerosis; Blood Pressure; Blood Vessels; Blood flow; Cardiac; Cardiovascular Diseases; Cardiovascular system; Caring; Chemistry; Complications of Diabetes Mellitus; Creatinine clearance measurement; Diabetes Mellitus; Echocardiography; Electrolytes; Exercise; Filtration; Functional disorder; Glycosylated Hemoglobin; Health; Hemoglobin; Histology; Human; In Vitro; Investigation; Kidney; Kidney Diseases; Lipids; Measurement; Metabolic; Methods; Modeling; Modification; Monitor; Morbidity - disease rate; Morphology; Mus; Patients; Performance; Phenotype; Postoperative Period; Purpose; Range; Rate; Regulation; Renal function; Rest; Risk; Screening procedure; Serum; Services; Stress Echocardiography; Stroke; Techniques; Telemetry; Testing; Urine; Vasomotor; diabetic cardiomyopathy; genetic manipulation; hemodynamics; indexing; mortality; mouse model; response; size

Cardiovascular and renal complications, including atherosclerosis and lipid abnormalities, diabetic cardiomyopathy, stroke and renal disease, comprise the major morbidity and mortality in diabetes. The complications of diabetes mellitus in mice appear to be largely the same as in humans. The purpose of the Cardiovascular Pathophysiology and Complications Core (CPCC) is to provide rapid, comprehensive, and accurate screening for cardiovascular disease and complications of diabetes in mouse models. The mouse phenotyping tests used by this Core are modeled after and directly translatable to tests used to assess patients with diabetes. Core services include assessment of a) cardiac morphology and function, including morphology, histology and echocardiography; b) vascular regulation, including resting measurement of blood pressure and response to vasomotor perturbations; c) exercise capacity and metabolic function; d) comprehensive renal function; e) microvascular function; and f) circulating markers of cardiovascular disease including electrolytes, indices of renal function, glycated hemoglobin, and serum lipids. The range of phenotyping tests performed by the CPCC allows for thorough investigation of the presence, correlation with, and modification or amelioration of cardiovascular disease, as well as diabetic complications associated with specific genetic manipulations in the mouse.

心血管和肾脏并发症，包括动脉粥样硬化和血脂异常、糖尿病 心肌病、中风和肾脏疾病是糖尿病的主要发病率和死亡率。这 小鼠糖尿病并发症似乎与人类大致相同。目的 心血管病理生理学和并发症核心 (CPCC) 旨在提供快速、全面和 在小鼠模型中准确筛查心血管疾病和糖尿病并发症。鼠标 该核心使用的表型测试是模仿并直接转化为用于评估的测试 糖尿病患者。核心服务包括评估 a) 心脏形态和功能，包括 形态学、组织学和超声心动图； b) 血管调节，包括静息血液测量 压力和对血管舒缩扰动的反应； c) 运动能力和代谢功能； d) 综合肾功能； e) 微血管功能； f) 心血管疾病的循环标志物 包括电解质、肾功能指数、糖化血红蛋白和血脂。范围为 CPCC 进行的表型测试可以彻底调查其存在、相关性、 心血管疾病的改变或改善，以及与糖尿病相关的并发症 对小鼠进行特定的基因操作。