DEVELOPMENT OF MEDICAL COUNTERMEASURES TO MITIGATE AND/OR TREAT RADIATION-INDUCED LUNG INJURY AFTER A RADIOLOGICAL/NUCLEAR INCIDENT

制定医疗对策以减轻和/或治疗放射/核事件后辐射引起的肺损伤

• 批准号: 9478659
• 负责人: JIM HARRIS
• 金额: $ 138.02万
• 依托单位: LIGNAMED, LLC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9478659
• 关键词: Animal Model; Animals; Chemicals; Chest; Clinical; Contracts; Development; Drug Kinetics; Exposure to; Goals; Hour; Inflammatory; Injury; Ionizing radiation; Lung; Medical; Morbidity - disease rate; Nuclear; Nuclear Radiology; Oral; Pharmacodynamics; Pre-Clinical Model; Preclinical Testing; Process; Property; Radiation; Radiology Specialty; Research Support; Structure of parenchyma of lung; Therapeutic; Tissues; in vivo; lung injury

This contract will support research to accelerate the development of safe and effective medical products to mitigate and/or treat pulmonary injury arising from exposure to ionizing radiation from a radiological or nuclear incident, thereby leading to a reduction in lung-associated morbidities that can impact survival. Currently, there are no approved therapeutic products in the Strategic National Stockpile (SNS) to be used specifically for radiation-induced pulmonary injury.

该合同将支持研究，以加速安全有效的医疗产品，以减轻和/或治疗来自放射线或核事件的电离辐射引起的肺部损伤，从而导致肺相关的病原体降低，从而影响生存率。目前，在战略国家库存（SNS）中尚无批准的治疗产品，专门用于辐射引起的肺部损伤。