5-D Image Guided Cardiac Ablation Therapy

5 维图像引导心脏消融治疗

• 批准号: 7618125
• 负责人: RICHARD A ROBB
• 金额: $ 44.19万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-20 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7618125
• 关键词: Ablation; Algorithms; Anatomy; Animal Experiments; Animals; Arrhythmia; Atrial Fibrillation; Biomedical Engineering; Cardiac; Cardiac ablation; Catheters; Clinical; Computer software; Computers; Data; Development; Devices; Evaluation; Generations; Health; Heart; Human; Image; Imagery; Maintenance; Maps; Methods; Modeling; Morbidity - disease rate; Motion; Operative Surgical Procedures; Outcome; Pacemakers; Patients; Performance; Pharmaceutical Preparations; Physiological; Physiology; Procedures; Process; Production; Pulmonary vessels; Reproduction; Robotics; Scientist; Signal Transduction; Solutions; Specific qualifier value; System; Technology; Testing; Thoracic Surgical Procedures; Time; Update; Validation; Work; base; computer generated; cost; design; design and construction; flexibility; human subject; imaging modality; improved; mortality; novel; prototype; radiologist; respiratory; treatment strategy

DESCRIPTION (provided by applicant): Cardiac arrythmias are a major clinical health problem. We have developed a significant and unique solution. We have designed and constructed a novel prototype system which integrates, in real-time, all image and associated physiological variables, device signals and computer generated data derived therefrom required for accurate and precise navigation and targeting in catheter-based ablation of cardiac arrhythmias. The system will render obsolete or unnecessary current approaches to treatment of cardiac arrhythmias, including present ablation methods, open chest surgery and pacemakers and medications in the many cases they don't work. The system design is open and flexible, permitting ready integration of new imaging modalities, interventional devices and physiologic signals as they become available. This system has achieved, for the first time, real-time performance in fusing dynamic cardiac anatomy with physiologic signals. Based on preliminary progress, we now can specify the enhancements required for seamless clinical implementation and application. These improvements include hardware upgrades for performance optimization and interface expansion, new and advanced algorithms for segmentation and registration, precise interactive catheter-to-anatomy navigation using image-guided robotic manipulators, and continuous tracking of respiratory and cardiac cycles for more precise mapping of physiology to anatomy, with more accurate rendering and display of time-patient-specific models of the heart throughout the cardiac cycle. We propose to thoroughly evaluate the enhanced system in both animal experiments and human studies. During this evaluation we will refine and optimize the user interface and procedure flow. We will then specify and assemble a "production" system fully compatible with the clinical procedure room. This production unit will be reproducible and transportable. The multi-disciplinary team of biomedical engineers, cardiologists, radiologists and computer scientists will continue to focus on atrial fibrillation where current treatment strategies are especially ineffective. But the system will be readily adaptable to treatment of any cardiac arrythmias that can be reached by a catheter. This system will herald a new generation of technology for treatment of cardiac arrhythmias resulting in significant clinical benefits, including reduced morbidity, mortality, procedure time, x-ray exposure and cost, with dramatically improved performance and outcomes.

描述（由申请人提供）：心脏雅典是一个主要的临床健康问题。我们已经开发了一个重要而独特的解决方案。我们设计并构建了一个新型的原型系统，该系统将实时集成所有图像和相关的生理变量，设备信号和计算机生成的数据，从中得出，以精确，精确的导航和靶向基于导管的心律心律失常的消融所需的数据。该系统将使心脏心律不齐的治疗方法过时或不必要的方法，包括目前的消融方法，开放性胸部手术以及起搏器以及在许多情况下无法使用的情况。系统设计是开放且灵活的，允许在可用时准备好将新成像方式，介入设备和生理信号整合。该系统首次实现了与生理信号融合动态心脏解剖结构的实时性能。基于初步进展，我们现在可以指定无缝临床实施和应用所需的增强功能。这些改进包括用于性能优化和界面扩展的硬件升级，用于细分和注册的新算法，使用图像引导的机器人机器人操纵器进行精确的互动导管到解剖学导航，以及呼吸道和心脏周期的持续跟踪，以更精确地绘制呼吸道和心脏周期，以进行整个循环，并在整个范围内进行整个循环范围，并进行整个模型，并进行整个过程，并进行整个过程。我们建议在动物实验和人类研究中彻底评估增强系统。在此评估期间，我们将完善并优化用户界面和过程流。然后，我们将指定并组装与临床程序室完全兼容的“生产”系统。该生产单元将是可再现和可运输的。生物医学工程师，心脏病学家，放射科学家和计算机科学家的多学科团队将继续专注于当前治疗策略尤为无效的房颤。但是，该系统将很容易适应导管可以达到的任何心脏芳香族的治疗。该系统将预示新一代的技术治疗心律不齐，从而带来明显的临床益处，包括降低发病率，死亡率，程序时间，X射线曝光和成本，并有了显着改善的性能和结果。