Development of Medical Multiphoton Microscopic Endoscopy
医用多光子显微内窥镜的发展
基本信息
- 批准号:7596376
- 负责人:
- 金额:$ 106.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-06-01 至 2012-03-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAnatomyAnimalsAreaAtlasesAustraliaBackBiologicalBiomedical EngineeringBiophysicsBiopsyBiopsy SpecimenBiotechnologyCaliberCancer DiagnosticsCellsCellular biologyCharacteristicsClassificationClinicalClinical MedicineCollaborationsCollagenColonoscopyColorComplexComputer Systems DevelopmentConceptionsConfocal MicroscopyCouplingCustomDataDatabasesDetectionDevelopmentDevicesDiagnosisDiagnosticDiagnostic ImagingDisadvantagedDiseaseDistalDocumentationEffectivenessEndoscopesEndoscopyEngineeringEnsureEvaluationFeedbackFiberFiber OpticsFluorescenceFoundationsFundingGastroenterologyGenerationsGrantHealthHealthcareHearingHistologyHumanHuman ResourcesHuman bodyImageImage AnalysisImaging technologyIn SituIndustryIntellectual PropertyJapanLabelLaboratoriesLaboratory ResearchLaser Scanning MicroscopyLasersLeadLegal patentLengthLibrariesLifeLightLightingLiteratureLocationLung noduleMalignant NeoplasmsMalignant neoplasm of ovaryManufacturer NameMechanicsMedicalMedical ImagingMedical TechnologyMedicineMetabolismMethodologyMethodsMicroscopeMicroscopicMicroscopyMicrotubule BundleMiniaturizationModern MedicineMotivationMusNanostructuresNational Institute of Biomedical Imaging and BioengineeringNatureNeedle biopsy procedureNeurodegenerative DisordersNeurosciencesNew York CityOccupationsOperative Surgical ProceduresOpticsOrganParticipantPathologistPathologyPathway interactionsPatientsPhysiciansPhysicsPhysiologic pulsePhysiologyPostdoctoral FellowPreparationProceduresProductionPropertyPublic HealthPublicationsPublishingQualifyingQuality ControlReportingResearchResearch SupportReservationsResolutionResourcesRoboticsSamplingSapphireScanningScientistServicesSignal TransductionSilicon DioxideSolidSourceSpectrum AnalysisStagingStaining methodStainsStructureSupervisionSurfaceSurgeonSurveysSystemTechniquesTechnologyTechnology TransferTestingTimeTissuesTokyoTrainingTransgenic MiceTransgenic ModelUncertaintyUnited States National Institutes of HealthUniversitiesValidationWorkabsorptionbasecancer imagingclinical Diagnosisdesigndigitaldirect applicationevidence baseexperienceflexibilityfollow-uphuman tissuein vivoinnovationinstrumentinstrumentationinterestlight transmissionmedical schoolsmedical specialistmedical specialtiesminiaturizeoptical communicationoptical fiberoptical imagingprofessorprogenitorprogramsquantumresearch and developmentresponserobotic devicesecond harmonicsuccesstechnology developmenttissue fixingtooltool developmenturologicuser-friendly
项目摘要
DESCRIPTION (provided by applicant): The ultimate objective of this Bioengineering Research Partnership is creation of significant advances in the functional effectiveness of medical endoscopy for public health care by enabling the real-time, in situ incorporation of the biophysical micro-imaging of the intrinsic diagnostic properties of tissue in vivo. The fluorescence and second harmonic generation in tissue images by multiphoton microscopy (MPM) without the need for extrinsic labeling are expected to enable effective medical utilization of the capabilities of MPM for in vivo detection and diagnostic recognition of maladies such as cancers, collagen structure damage, and fibrotic disease states, etc., by MPM Endoscopy. MPM Endoscopy will utilize the MPM imaging capabilities discovered and analyzed in biophysical laboratory research, including living preparations, and transgenic model animals displaying various disease states - with validation by histology. MPM was invented and continues to be advanced through associated research programs of the PI and key personnel at Cornell University, and now with Weill Medical College of Cornell University. The first essential aim is development of the data foundation for use in human medicine with MPM images of fresh medical biopsies compared to their appraisal and validation by collaborating pathologists' histology and clinical diagnoses, leading to production of atlases of diagnostic MPM images at Weill Medical's laboratory for eventual dissemination. To accomplish this transition of the MPM tissue imaging capabilities from the laboratory to medical application via MPM endoscopy, a representative cadre of physicians and surgeons at Cornell Weill Medical have assembled to partner in testing and evaluating this capability in their diverse specialties. Simultaneously, an essential aim is development of hyper-miniaturized, reliable MPM endoscopic apparati compatible with the diverse geometries required for various organs of human physiology, which can progress in parallel with more accessible designs for equipping of larger scale endoscopies. Despite published progenitors, instrumentation comprises the major developmental challenge of the program. To accomplish this objective, innovative research by our key personnel with established expertise in ultrafast optics and nanostructure fabrication is invoked to design, fabricate and test potential systems. Biomedical engineering of microscopy components installed in endoscopy apparati is required for testing, ultimately in human MPM Endoscopy applications initially by our collaborating MD's. Finally, technology transfer to commercial manufacturers to provide medical instrument availability is required to achieve the ultimate objective of this: new medical capability.
描述(申请人提供):这种生物工程研究伙伴关系的最终目标是通过实现实时纳入生物物理微型图像的实时纳入,从而在医疗内窥镜检查对公共卫生保健的功能有效性方面取得了重大进步。通过多光子显微镜(MPM)在组织图像中的荧光和第二次谐波生成,而无需外在标签,预计将有效地医学利用MPM在体内检测和诊断识别的能力,例如癌症,cANCERS,例如CANCER,COLLAGEN结构损坏,纤维化疾病状态等。 MPM内窥镜检查将利用在生物物理实验室研究中发现和分析的MPM成像功能,包括生活制剂以及表现出各种疾病状态的转基因模型动物 - 通过组织学验证。 MPM是通过PI的相关研究计划和康奈尔大学的关键人员以及康奈尔大学的Weill Medical College的。第一个基本目的是开发与新鲜医疗活检MPM图像的数据基础相比,与他们通过合作的病理学家的组织学和临床诊断相比,将其评估和验证与验证相比,从而在Weill Medical的实验室中生产了诊断MPM图像的地图集。为了通过MPM内窥镜检查从实验室到医疗应用的MPM组织成像能力的过渡,康奈尔·威尔医学公司(Cornell Weill Medical)的医师和外科医生的代表干部已召集了与他们在各种专业中进行测试和评估这种能力的合作伙伴。同时,一个重要的目的是开发超时性,可靠的MPM内窥镜设备与人类生理学各种器官所需的多种几何形状兼容,这可以与更易于使用的较大规模内窥镜的设计同行进行。尽管发表了祖细胞,但仪器还是该计划的主要发展挑战。为了完成我们的关键人员的目标,具有超快光学和纳米结构制造方面的专业知识的创新研究,以设计,制造和测试潜在的系统。测试中需要安装在内窥镜检查中的显微镜组件的生物医学工程,最终是在人类MPM内窥镜应用中,最初是由我们的合作MD进行的。最后,需要技术转移到商业制造商以提供医疗工具的可用性,以实现这一目标的最终目标:新的医疗能力。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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WATT W WEBB其他文献
WATT W WEBB的其他文献
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{{ truncateString('WATT W WEBB', 18)}}的其他基金
Development of Medical Multiphoton Microscopic Endoscopy
医用多光子显微内窥镜的发展
- 批准号:
7425824 - 财政年份:2007
- 资助金额:
$ 106.27万 - 项目类别:
Development of Medical Multiphoton Microscopic Endoscopy
医用多光子显微内窥镜的发展
- 批准号:
7800442 - 财政年份:2007
- 资助金额:
$ 106.27万 - 项目类别:
Development of Medical Multiphoton Microscopic Endoscopy
医用多光子显微内窥镜的发展
- 批准号:
7172760 - 财政年份:2007
- 资助金额:
$ 106.27万 - 项目类别:
Development of Medical Multiphoton Microscopic Endoscopy
医用多光子显微内窥镜的发展
- 批准号:
8048113 - 财政年份:2007
- 资助金额:
$ 106.27万 - 项目类别:
Nascent Dynamic Intermediates in Amyloid Aggregation
淀粉样蛋白聚集中的新生动态中间体
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6963283 - 财政年份:2005
- 资助金额:
$ 106.27万 - 项目类别:
Nascent Dynamic Intermediates in Amyloid Aggregation
淀粉样蛋白聚集中的新生动态中间体
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7140349 - 财政年份:2005
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$ 106.27万 - 项目类别:
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多光子显微镜应用咨询
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6349480 - 财政年份:2000
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电话咨询:大鼠脑部成像 (10
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