COCOA, POLYPHENOLS AND THE KIDNEY IN HEALTHY HUMANS

可可、多酚和健康人的肾脏

• 批准号: 7607364
• 负责人: NORMAN K HOLLENBERG
• 金额: $ 7.15万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607364
• 关键词: Blood; Cocoa Powder; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Human; Institution; Kidney; Measures; Metabolic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Urine; Vascular blood supply; hemodynamics; polyphenol

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To expose the possibility that the mechanism which polyphenol-rich cocoa influences renal hemodynamics involves activation of intrarenal nitric oxide synthase. To make that assessment, we are measuring the metabolic products of nitric oxide synthesis in urine and blood, and assessing the influence on the renal blood supply of blocking nitric oxide synthesis with L-NAME. This is an investigator-initiated study.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 揭示富含多酚的可可影响肾脏血流动力学的机制可能涉及激活肾内一氧化氮合酶。 为了进行评估，我们测量了尿液和血液中一氧化氮合成的代谢产物，并评估了用 L-NAME 阻断一氧化氮合成对肾脏血液供应的影响。 这是一项由研究者发起的研究。