TMS FOR PAIN IN CHRONIC PANCREATITIS

TMS 治疗慢性胰腺炎疼痛

• 批准号: 7606943
• 负责人: Steven David Freedman
• 金额: $ 5.99万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606943
• 关键词: Adverse effects; Analgesics; Computer Retrieval of Information on Scientific Projects Database; Equilibrium; Functional disorder; Funding; Glutamates; Grant; Institution; Intake; Magnetic Resonance Imaging; Measures; Pain; Patients; Physiological; Pilot Projects; Population; Protocols documentation; Purpose; Quality of life; Relative (related person); Research; Research Personnel; Resources; Safety; Source; United States National Institutes of Health; Visceral pain; Visual Analogue Pain Scale; chronic pancreatitis; experience; gamma-Aminobutyric Acid; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this protocol is to investigate a possible novel treatment for intractable visceral pain in patients with chronic pancreatitis. The first aim of this study is to examine whether slow repetitive TMS (rTMS) applied to SII in patients with pain and chronic pancreatitis has an analgesic effect as measured by changes in the Visual Analogue Scale (VAS) for pain and a decrease in analgesic intake, as well as an overall improvement in quality of life. The second aim of the study is to assess the safety of rTMS in this patient population. In the pilot study done previously none of the patients experienced any adverse effects of a single session of rTMS. The hypothesis of this aim is that the proposed rTMS protocol will be safe for this patient population. The third aim of the study is to study the physiologic mechanism of action of rTMS in these patients using magnetic resonance imaging (MRI). They hypothesize that the balance of GABA and glutamate will be abnormal in SII in patients with pain from chronic pancreatitis, with a relative decrease in GABA and increase in glutamate indication an abnormal, hyperexcitabile dysfunction. This abnormality will be normalized by rTMS in correlation with its analgesic effect.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该方案的目的是研究一种可能的治疗慢性胰腺炎患者顽固性内脏疼痛的新方法。本研究的首要目的是通过疼痛视觉模拟量表 (VAS) 的变化和镇痛药摄入量的减少来衡量，慢速重复 TMS (rTMS) 应用于疼痛和慢性胰腺炎患者的 SII 是否具有镇痛效果，以及生活质量的全面改善。 该研究的第二个目的是评估 rTMS 在该患者群体中的安全性。在之前进行的试点研究中，没有患者经历过单次 rTMS 的任何不良反应。该目标的假设是所提出的 rTMS 方案对于该患者群体是安全的。该研究的第三个目的是利用磁共振成像（MRI）研究 rTMS 在这些患者中作用的生理机制。他们推测慢性胰腺炎疼痛患者的 SII 中 GABA 和谷氨酸的平衡会出现异常，GABA 相对减少而谷氨酸增加表明存在异常的过度兴奋性功能障碍。这种异常现象将通过 rTMS 与其镇痛效果相关而正常化。