Prenatal stress and the development of inhibitory neurons in the forebrain

产前应激和前脑抑制性神经元的发育

基本信息

批准号：
8952328
负责人：
HANNA E STEVENS
金额：
$ 8.73万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2015-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8952328
关键词：
Acute Address Adolescent Adult Affect Amygdaloid structure Animal Model Animals Anxiety Apoptotic Area Award Behavior Behavior Disorders Behavioral Brain Brain-Derived Neurotrophic Factor Cell Count Cell Death Cell Maturation Cells Child Childhood Clinical Clinical Research Data Development Development Plans Disease Doctor of Philosophy Educational workshop Electrophysiology (science)Embryo Event Functional disorder Funding Gilles de la Tourette syndrome Goals Green Fluorescent Proteins Growth Factor Hippocampus (Brain)Human Hypothalamic structure In Situ Hybridization Individual Intervention K-Series Research Career Programs Laboratories Learning Limbic System Link Measures Medial Mediating Mediator of activation protein Mental disorders Mentors Molecular Mus Neonatal Neuroanatomy Neurobiology Neurons Neurosciences Neurosciences Research Neurosecretory Systems Parvalbumins Patients Performance Phenotype Population Prefrontal Cortex Pregnancy Pregnant Women Property Prosencephalon Psychiatric therapeutic procedure Psychiatry Recruitment Activity Regulation Research Research Proposals Schizophrenia Slice Somatostatin Staging Stress Structure Survival Analysis System Techniques Time Training United States National Institutes of Health Western Blotting Work base calretinin career career development cholinergic cingulate cortex depressive symptoms design developmental neurobiology experience functional outcomes gamma-Aminobutyric Acid in vitro activity in vivo inhibitory neuron interest knowledge base mature animal migration neurobiological mechanism neurodevelopment neuron development offspring postnatal prenatal prenatal exposure prenatal stress programs promoter research study response septohippocampal skills social stem cells symposium transcription factor

项目摘要

DESCRIPTION (provided by applicant: This application presents a career development award that integrates clinical child and adult psychiatry, animal models of developmental neuroscience, and stress neurobiology. The immediate goal is to create a program investigating the developmental mechanisms of the neurobiological effects of prenatal stress, focused on inhibitory neurons. The long term objective is to contribute to the understanding of early developmental events that contribute to severe childhood and adult psychiatric illness, the pathophysiology that underlies disorders such as schizophrenia and Tourette syndrome, and how interventions can modify early developmental changes. The candidate completed a Ph.D. in neuroscience with individual NIH funding and has now been involved in comprehensive training in clinical and research psychiatry for the past 5 years at the Yale Child Study Center (YCSC) and Department of Psychiatry. This award will provide critical support for the continuation of her integrated research in the YCSC Developmental Neurobiology Laboratory and the transition to an independent career in basic developmental neuroscience within the framework of understanding child and adult psychiatric illness. In the research proposal, an animal model of prenatal stress will be used to study the mechanisms of widespread, persistent effects on CNS structure and function. GABAergic systems will be the focus of the research plan, as patients with schizophrenia and other behavioral disorders linked to prenatal stress in humans have abnormal GABAergic neuron populations. Dr. Stevens will complete the first stage of the research plan on the anatomical effects of prenatal stress on inhibitory neurons with the support of this award and the skills she has developed in her postdoctoral work. She will then go on to make assessments of molecular mechanisms of prenatal stress affecting GABAergic populations both during the embryonic time period and during adult development. Functioning of inhibitory neuronal systems will be examined with behavioral and electrophysiological measures. This experimental work also comprises the career development plan for this candidate to obtain the necessary skills for an independent career in basic neuroscience research that can investigate important questions about the neurodevelopment of mental illness. The candidate has recruited an outstanding group of mentors and advisors that will guide the research plan in design, performance of experiments, and analysis of results. For career development, this mentor and advisor team will continue to support the candidate as she develops an independent laboratory program at the YCSC relevant to the neurodevelopment of mental illness and as she pursues additional training in molecular, behavioral, and electrophysiological techniques through coursework, intensive workshops and national conferences.

描述（由申请人提供：本申请颁发了一项职业发展奖，该奖项将临床儿童和成人精神病学，发育神经科学的动物模型和压力神经生物学模型整合在一起。直接的目标是制定一个计划，研究一个计划，调查产前压力的神经生物学效应的发育机制，重点是抑制儿童，以促进抑制性的事件。诸如精神分裂症和图雷特综合症之类的疾病的病理学是如何改变候选人的早期发展。在了解儿童和成人精神病的框架内，YCSC的发展神经生物学实验室以及向基本发展神经科学领域独立的职业过渡。在研究建议中，将使用产前应力的动物模型来研究对中枢神经系统结构和功能的广泛，持续影响的机制。 GABA能系统将成为研究计划的重点，因为精神分裂症患者和其他与人类产前压力相关的行为障碍患者患有异常的GABA能神经元种群。史蒂文斯（Stevens）博士将在研究计划的第一阶段就该奖项的支持以及她在博士后工作中发展的技能，对产前压力对抑制性神经元的解剖作用。然后，她将继续评估胚胎时期和成人发育期间影响GABA能种群的产前应激的分子机制。抑制性神经元系统的功能将通过行为和电生理学措施进行检查。这项实验工作还包括该候选人的职业发展计划，以获得基本神经科学研究中独立职业的必要技能，这些技能可以调查有关精神疾病神经发展的重要问题。该候选人招募了一群出色的导师和顾问，他们将指导设计计划，实验表现和结果分析。对于职业发展，该导师和顾问团队将继续支持该候选人，因为她在与精神疾病的神经发育有关的YCSC开发独立实验室计划时，以及她通过通过课程，强化工作室和国家会议进行分子，行为和电生理技术的额外培训。