THE EFFECTS OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART)

高活性抗逆转录病毒治疗 (HAART) 的效果

• 批准号: 7607863
• 负责人: Sharon A Nachman
• 金额: $ 1.15万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-23 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607863
• 关键词: Blood; Blood Cells; Blood typing procedure; Cells; Child; Computer Retrieval of Information on Scientific Projects Database; Disease; Drug Combinations; Funding; Grant; HIV; HIV Infections; Highly Active Antiretroviral Therapy; Immune; Immune system; Infection; Institution; Purpose; Research; Research Personnel; Resources; Source; United States Food and Drug Administration; United States National Institutes of Health; Vaccines; Virus; antiretroviral therapy; fighting

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV damages the immune system by infecting many different types of blood cells in the body. Some of the infected cells are supposed to protect the body from disease by helping to fight infections, such as HIV. When these cells become infected, they are not able to fight infections and eventually the cells die. As a result, a child's immune system gets weak. When a child takes a combination of drugs for the treatment of HIV infection (HAART), the virus is not able to multiple as quickly and the cells of the immune system can help fight infection. The purpose of this study is to tell how many immune cells return, and the amount of HIV in the blood while he/she is on HAART. In order to study a child's immune system, he/she will receive two different vaccines which are approved by the FDA for children.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 HIV 通过感染体内许多不同类型的血细胞来损害免疫系统。一些受感染的细胞应该通过帮助抵抗艾滋病毒等感染来保护身体免受疾病侵害。当这些细胞被感染时，它们无法抵抗感染，最终细胞死亡。结果，孩子的免疫系统变弱。 当儿童服用治疗艾滋病毒感染 (HAART) 的药物组合时，病毒无法快速繁殖，免疫系统细胞可以帮助抵抗感染。本研究的目的是了解在接受 HAART 治疗期间有多少免疫细胞恢复，以及血液中 HIV 的含量。为了研究儿童的免疫系统，他/她将接受 FDA 批准用于儿童的两种不同疫苗。