SIDE-VIEWING RAMAN OPTICAL FIBER PROBE FOR BIOMEDICAL SPECTROSCOPY

用于生物医学光谱学的侧视拉曼光纤探头

• 批准号: 8364148
• 负责人: NARAHARA CHARI DINGARI
• 金额: $ 2.97万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364148
• 关键词: Biomedical Research; Breast; Breast Microcalcification; Calcium; Clinical Research; Core Biopsy; Deposition; Devices; Fiber; Fiber Optics; Funding; Grant; Lasers; Light; Mammary Gland Parenchyma; Mammography; Minerals; National Center for Research Resources; Needle biopsy procedure; Needles; Principal Investigator; Raman Spectrum Analysis; Research; Research Infrastructure; Resources; Salts; Screening procedure; Side; Signal Transduction; Source; Spectrum Analysis; Time; United States National Institutes of Health; clinically significant; cost; design; in vivo; optical fiber

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are investigating the usage of Raman spectroscopy to guide stereotactic core needle biopsies of the breast for suspicious microcalcifications discovered at screening mammography. Microcalcifications are deposits of calcium mineral salts within breast tissue that mammographically localize the most clinically significant abnormality and are, therefore, a target for subsequent needle biopsy. Raman spectroscopy is exquisitely sensitive to the presence of calcium-containing minerals, and thus can be used to detect and localize microcalcifications in the breast. This can be done in vivo, in real-time, in a non-destructive manner, via optical fiber probes that are compatible with existing needle biopsy devices. The side-viewing Raman fiber optic probe provides capability of utilizing the excitation light from Raman source and delivering to and collecting the light from the breast tissue while the probe inserted into needle device. The probe is designed to fit into 9 gauge needle device most commonly used during stereotactic core needle biopsies. Similar to the front-viewing Raman probe that has been successfully used in the in vivo and ex vivo clinical studies, the side-viewing probe incorporate excitation and emission filters with coatings to suppress fiber background and enable efficient extraction of the Raman signal.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 我们正在研究拉曼光谱法的使用，以指导乳房的立体定向核心针活检，以进行筛查乳房X线摄影时发现的可疑微钙化。微钙化是乳腺组织中钙矿物质盐的沉积物，在乳房组织中定位最显着的异常，因此是随后的针头活检的靶标。 拉曼光谱法对含钙的矿物质的存在非常敏感，因此可用于检测和定位在乳房中的微钙化。这可以通过与现有针头活检装置兼容的光纤探针实时实时实时实时进行。侧观看拉曼光纤探针提供了利用拉曼源的激发灯，并从乳腺组织中传递并收集光线，而探测器插入针头装置。该探针的设计旨在适合9号针头装置，最常用于立体定向的核心针活检中。类似于在体内和离体临床研究中成功使用的前视拉曼探针，侧视图探针与涂层一起融合了激发和发射过滤器，以抑制纤维背景并有效提取拉曼信号。