MARC - DEVELOPING BIOINFORMATICS PROGRAMS, JULY 2009

MARC - 开发生物信息学项目，2009 年 7 月

• 批准号: 8364394
• 负责人: HUGH B NICHOLAS
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364394
• 关键词: Algorithms; Bioinformatics; Biological; Biology; Biomedical Research; CCL7 gene; Chemistry; Databases; Educational process of instructing; Educational workshop; Engineering; Evaluation; Faculty; Foundations; Funding; Goals; Grant; High Performance Computing; Homology Modeling; Individual; Institutes; Institution; Internet; Mathematics; Methods; National Center for Research Resources; Participant; Pattern; Physics; Positioning Attribute; Principal Investigator; Programming Languages; Research; Research Infrastructure; Resources; Sequence Alignment; Source; Structure; Students; Trees; United States National Institutes of Health; Weight; computer science; cost; interest; markov model; molecular dynamics; programs; statistics; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Summer Institute in Bioinformatics is a two-week course, directed towards faculty, students and staff at MARC program institutions. The Summer Institute has the goal of preparing the participants to teach bioinformatics courses at their local campuses. Interested individuals associated with a MARC program institution are encouraged to apply, including faculty from diverse departments, including biology, chemistry, physics, mathematics, statistics, computer science, and engineering. The workshop will introduce participants to the computational, mathematical and biological issues surrounding bioinformatics. A number of fundamental topics in bioinformatics will be discussed including inferring structures and functions; database searching and pairwise sequence alignment; multiple sequence alignments; pattern identification. Special emphasis will be placed on parameter selection, and the mathematical, statistical, and biological foundations of the algorithms and methods presented. Information will also be provided on hidden Markov models, advanced position-specific weight matrices, bayesian estimation, homology modeling, structural biology, molecular dynamics simulations, and phylogenic tree creation and evaluation. The use of internet resources and remote computing facilities will also be discussed as will an introduction Biology for non-biologists and an introduction to the PERL programming language for biologists.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 生物信息学的夏季学院是为期两周的课程，针对MARC计划机构的教职员工和员工。夏季学院的目标是准备参与者在当地校园教生物信息学课程。鼓励与MARC计划机构相关的有兴趣的人申请，包括来自不同部门的教职员工，包括生物学，化学，物理，数学，统计学，计算机科学和工程。 研讨会将向参与者介绍有关生物信息学的计算，数学和生物学问题。将讨论许多生物信息学的基本主题，包括推断结构和功能；数据库搜索和成对序列对齐；多个序列比对；模式识别。特别重点将放在参数选择上，以及介绍的算法和方法的数学，统计和生物基础。还将在隐藏的马尔可夫模型，高级位置特异性重量矩阵，贝叶斯估计，同源性建模，结构生物学，分子动力学模拟以及系统发育树创造和评估上提供信息。还将讨论Internet资源和远程计算设施的使用，这将是针对非生物学家的生物学介绍，并介绍了生物学家Perl编程语言的介绍。