EXTRACTING WIRING DIAGRAMS FROM NEURONAL CIRCUITS

从神经元电路中提取接线图

• 批准号: 8364225
• 负责人: R CLAY REID
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364225
• 关键词: Biomedical Research; Brain; Data Set; Electron Microscopy; Funding; Grant; High Performance Computing; Image; National Center for Research Resources; Nerve Tissue; Neurons; Principal Investigator; Process; Research; Research Infrastructure; Resolution; Resources; Source; United States National Institutes of Health; Work; cost; nanometer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The wiring diagrams of neuronal circuits may be obtained from electron microscopy (EM) images of serially cut, ultrathin (<50 nm) sections through nervous tissue. In the mammalian brain, even local circuits may span hundreds to thousands of microns in space. Images spanning hundreds of microns at nanometer resolution consume many gigabytes of storage. We are working with people at PSC to develop a high throughput pipeline for processing and analysis of these very large data sets.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 神经元电路的接线图可以从通过神经组织的串行切割，超薄（<50 nm）切片的电子显微镜图（EM）图像获得。在哺乳动物的大脑中，即使是当地电路也可能跨越空间中数百至数千微米。在纳米分辨率下跨越数百微米的图像消耗了许多千兆字节的存储空间。我们正在与PSC的人员合作，开发高吞吐量管道来处理和分析这些非常大的数据集。