INTRODUCTION TO BIOINFORMATICS

生物信息学导论

• 批准号: 8364383
• 负责人: Shalun Lewis
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364383
• 关键词: Algorithms; Arabidopsis; Area; Bacillus subtilis; Base Sequence; Bioinformatics; Biology; Biomedical Research; Chemistry; Collection; Computers; Culicidae; DNA; Data; Databases; Discipline; Educational process of instructing; Escherichia coli; Exercise; Faculty; Funding; Genes; Genome; Genomics; Goals; Grant; High Performance Computing; Human; Human Genome; Internet; Internships; Laboratories; Legal patent; Mathematics; Medicine; Methods; Minority; Molecular; Molecular Biology; Mus; National Center for Research Resources; Operating System; Pattern; Phylogenetic Analysis; Plants; Polymerase Chain Reaction; Principal Investigator; Pythons; Rattus; Research; Research Infrastructure; Resources; Rice; Schedule; Scientist; Sequence Alignment; Source; Students; Technology; United States National Institutes of Health; Universities; Withdrawal; Writing; career; computer science; cost; experience; interest; journal article; lectures; meetings; member; microorganism; rat genome; statistics; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. CATALOG DESCRIPTION Bioinformatics is a collection of methods used for analyzing molecular biology data with a computer. A team of Langston University faculty from various disciplines (chemistry, biology, mathematics, computer science, and research) will teach this course with the goal of cultivating research-oriented minority students for careers in bioinformatics. Interested students can compete for summer internships at PSC. RATIONALE Bioinformatics is an area of research developing as a result of the Human Genome Initiative and the advent of the World Wide Web, shortly thereafter. Once patented technology such as the polymerase chain reaction and the DNA sequencer were developed, molecular biologist began sequencing entire genomes from human, rat, and mouse to plants, such as rice and Arabidopsis, to microorganisms such as E. coli and Bacillus subtilis. The scientist quickly realized that someone needed to provide tools for collection, storage, and analysis of this exponentially growing amount of nucleotide sequences. Computer scientist were needed to write scripts to allow for the assembly of entire genomes and comparison of genes within the genomes and between genomes (rat with human with mosquitos. Computer scientist quickly realized that mathematicians were needed for the intricate details of statistics, algorithms, and matrices. Bioinformatics is a multi-disciplinary field that is constantly evolving to meet the demands of the post-genomic area, if there is one, aiming for the diminishless field of personalized medicine. COURSE OBJECTIVES The student should: 1. Define Bioinformatics and understand how this discipline evolved. 2. Complete the Unix Operating System Hands- On Exercise. 3. Retrieve Sequences from Databases and Complete Hands- On Exercise. 4. Complete the Database Searching and Alignment Hands-On Exercise. 5. Complete the Multiple Sequence Alignment Hands-On Exercise. 6. Complete the Pattern Identification and Matching Hands-On Exercise. 7. Complete the Python Exercises. 8. Complete the Phylogenetic Analysis Hands-On Exercises. 9. Complete the Finding Features in Groups of Sequences Hands-On Exercises. METHOD OF INSTRUCTION This class will be taught by a team of faculty who have experience in their fields of research. The faculty will use hands-on exercises, powerpoint presentations, and journal articles when presenting their information. COURSE REQUIREMENTS Each student should: 1. Attend all classes, punctually. 2. Complete all hands-on exercises. Take all exams or quizzes. 3. Complete your project. 4. Present your project. METHOD OF EVALUATION- Points for course requirements Each faculty member will assess the students as the subject matter lends itself. Minimum Grade Requirement: A = 90%; B = 80%; C = 70%; D = 60%; F = below 59% 3. Class Attendance It is imperative that students attend all lectures and labs. Material covered during each session is critical and is prerequisite to subsequent material. Material missed in one lecture can seriously hinder the student(s ability to comprehend related material. An attendance sheet will circulate at the beginning of class. Classes will be held daily. If no laboratory assignments are scheduled, then classes will be held in the recitation room. Six (6) absentees can result in an administrative withdrawal.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。对该子项目的主要支持和子弹的主要研究者可能由其他来源（包括其他NIH来源）提供。 该子项目列出的总成本可能代表了子项目使用的估计中心基础设施的估计数量，而不是NCRR赠款向子项目或副标理人员提供的直接资金。 目录描述生物信息学是用于使用计算机分析分子生物学数据的方法的集合。来自各个学科（化学，生物学，数学，计算机科学和研究）的兰斯顿大学教师团队将教授这门课程，目的是培养以研究为导向的少数族裔学生从事生物信息学的职业。有兴趣的学生可以在PSC竞争暑期实习。 理性生物信息学是由于人类基因组倡议和万维网的出现而发展的研究领域。一旦开发了专利的技术（例如聚合酶链反应和DNA测序仪），分子生物学家就开始对整个基因组进行从人，大鼠和小鼠到植物的整个基因组，例如水稻和拟南芥，例如大肠杆菌和枯草菌等微生物。科学家很快意识到，有人需要提供用于收集，存储和分析的工具，以呈指数增长的核苷酸序列。需要编写脚本来编写计算机科学家，以允许整个基因组组装和基因组中的基因和基因组之间的比较（与人类与蚊子的大鼠。计算机科学家很快意识到，数学家需要数学家才能获得统计学，算法，算法和矩阵的复杂细节。因此，生物信息是一个多difipial的领域，不断地符合Is的要求，而不是与众多的领域相遇，而不是与统计学家相遇，并且需要与之相遇。一个，旨在实现个性化医学的无限领域。 课程目标应该：1。定义生物信息学并了解该学科的发展方式。 2。完成锻炼时完成UNIX操作系统。 3。从数据库中检索序列，并完成锻炼。 4。完成数据库搜索和对齐动手练习。 5。完成多个序列对齐动手练习。 6。完成模式识别和匹配的动手练习。 7。完成Python练习。 8。完成系统发育分析动手练习。 9。完成一组序列动手练习的发现功能。 教学方法这堂课将由在研究领域有经验的教师团队教授。在介绍信息时，教师将使用动手练习，PowerPoint演示文稿和期刊文章。课程要求每个学生应：1。准时参加所有课程。 2。完成所有动手练习。参加所有考试或测验。 3。完成您的项目。 4。介绍您的项目。课程要求的评估方法 - 每个教职员工都会在主题上评估学生。最低等级要求：A = 90％； B = 80％; C = 70％； d = 60％; F =低于59％3。上课的学生必须参加所有讲座和实验室。每次会议期间涵盖的材料至关重要，并且是随后材料的先决条件。一个讲座中错过的材料可能会严重阻碍学生（S理解相关材料的能力。出勤表将在上课开始时流通。每天举行课程。如果没有安排实验室任务，则将在朗诵室中举行课程。六（6）个缺席者可以导致行政撤回。