METABOLIC CONSEQUENCE OF SICKLE CELL ANEMIA IN ADOLESCENCE

青少年镰状细胞贫血症的代谢后果

• 批准号: 7605530
• 负责人: MACIEJ S BUCHOWSKI
• 金额: $ 0.9万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605530
• 关键词: Adolescence; Adolescent; Cardiac Output; Computer Retrieval of Information on Scientific Projects Database; Daily; Energy Metabolism; Funding; Grant; Growth; Institution; Metabolic; Pathway interactions; Physical activity; Proteins; Rate; Research; Research Personnel; Resources; Sickle Cell Anemia; Source; United States National Institutes of Health; protein degradation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESIS: The central hypothesis of this GCRC proposal is that increased whole-body protein turnover and increased cardiac output, resulting in increased energy expenditure for basal needs and physical activity, divert energy and protein from normal growth pathways in HbSS adolescents. SPECIFIC AIMS: 1) To determine how much energy and protein is needed for optimal growth in adolescents w/HbSS. 2) To explain how growth rate in HbSS adolescents is altered by increased demands for energy caused by higher whole-body protein turnover and increased cardiac output. 3) To quantify how much energy and protein is required for daily physical activity in adolescents w/HbSS.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 假设： 该 GCRC 提案的中心假设是，全身蛋白质周转率增加和心输出量增加，导致基础需求和体力活动的能量消耗增加，从而使 HbSS 青少年的能量和蛋白质从正常生长途径转移。 具体目标： 1) 确定患有 HbSS 的青少年最佳生长需要多少能量和蛋白质。 2) 解释 HbSS 青少年的生长速度如何因全身蛋白质周转率升高和心输出量增加而引起的能量需求增加而改变。 3) 量化 HbSS 青少年日常体力活动需要多少能量和蛋白质。