Vasoactive Peptides that Stimulate Smooth Muscles

刺激平滑肌的血管活性肽

• 批准号: 7728646
• 负责人: ERVIN G ERDOS
• 金额: $ 39.25万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7728646
• 关键词: Agonist; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Antihypertensive Agents; Binding; Bradykinin; Cardiovascular Diseases; Cell surface; Development; Diabetic Nephropathy; Endothelial Cells; Enhancers; Enzymes; Generations; Grant; Heart; Human; Hydrophobic Surfaces; Hypertension; Investigation; Kidney Diseases; Kinins; Ligands; Mediating; Molecular; National Heart, Lung, and Blood Institute; Nitric Oxide; Output; Patients; Peptide Receptor; Peptides; Peptidyl-Dipeptidase A; Pharmaceutical Preparations; Receptor Activation; Receptor Signaling; Resistance; Roentgen Rays; Signal Pathway; Signal Transduction; Site; Smooth Muscle; Structure; Therapeutic; Therapeutic Agents; Zinc; combat; hypertensive heart disease; novel; peptide analog; receptor; receptor function; stem

We are applying for the renewal of our grant, continuously supported by NHLBI for about 47 years. The Aims stem from our initial investigations of enzymes that metabolize peptides such as bradykinin (BK), angiotensins and others. lilhibitors of angiotensin I converting enzyme (kininase II; ACE) are currently used to treat millions of patients with hypertension and various cardiovascular diseases. Although their therapeutic actions were thought to be due solely to blocking the generation of hypertensive angiotensin I and inactivation of hypotensive BK, ACE inhibitors enhance the effect of BK and its ACE-resistant peptide analogues on their receptors (B2, B1) by indirect and direct modes of actions.

我们正在申请续签我们的赠款，该赠款已由 NHLBI 持续支持了约 47 年。这些目标源于我们对代谢肽（如缓激肽 (BK)、血管紧张素等）的酶的初步研究。血管紧张素I转换酶（激酶II；ACE）的抑制剂目前用于治疗数百万高血压和各种心血管疾病患者。尽管ACE抑制剂的治疗作用被认为仅仅是由于阻断高血压血管紧张素I的产生和使低血压BK失活，但ACE抑制剂通过间接和直接增强BK及其ACE抗性肽类似物对其受体（B2、B1）的作用。行动方式。