Catalytic C-C bond forming hydrogenation for synthesis of anti-tumor natural prod

催化C-C键形成氢化合成抗肿瘤天然产物

基本信息

批准号：
8205271
负责人：
David J. Del Valle
金额：
$ 3.13万
依托单位：
UNIVERSITY OF TEXAS AT AUSTIN
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-24 至 2013-08-23
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The primary goal of the proposed funding period resides in the training of Mr. David Del Valle, such that he becomes competitive in the field of organic chemistry at the highest national level. The paramount training ground for a synthetic organic chemist is through total synthesis. Embarking on such an endeavor allows for the development of skills needed to synthesize complex molecules. These include the problem solving skills involved in synthesis planning, reaction optimization and the interpretation of results. He will develop in improve his abilities in these areas by working on the total synthesis of the ansamycin class of antitumor antibiotics. This research project will improve his abilities for independent thinking, interpretation of data and results, presentation of scientific data, and technical skill in organic chemistry. Two years of funding should be enough for David to train at the graduate student level. He will be the only student trained under the funding opportunity, and there will be about 20 students in the Krische group that he will interact with. PUBLIC HEALTH RELEVANCE: This research-training program will provide the basic chemistry research needed to begin investigating a new potential treatment for cancer. The program will also train a scientist how to make new medicines that will have a positive impact on public health.

描述（由申请人提供）：拟议资助期的主要目标在于培训 David Del Valle 先生，使他在国家最高水平的有机化学领域具有竞争力。合成有机化学家最重要的训练基地是全合成。开展这样的努力可以发展合成复杂分子所需的技能。其中包括合成计划、反应优化和结果解释中涉及的问题解决技能。他将通过研究安沙霉素类抗肿瘤抗生素的全合成来提高自己在这些领域的能力。该研究项目将提高他的独立思考、数据和结果解释、科学数据呈现以及有机化学技术技能的能力。两年的资金应该足以让大卫接受研究生级别的培训。他将是唯一接受该资助机会培训的学生，他将与 Krische 小组中大约 20 名学生进行互动。公共健康相关性：该研究培训计划将提供开始研究新的潜在癌症治疗方法所需的基础化学研究。该计划还将培训科学家如何制造对公众健康产生积极影响的新药物。