Alcohol Center Of Research -- Nebraska (ACORN)

内布拉斯加州酒精研究中心 (ACORN)

• 批准号: 10526252
• 负责人: Carol A. Casey
• 金额: $ 156.95万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-28 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10526252
• 关键词: Address; Age; Aging; Alcohol consumption; Alcoholic Fatty Liver; Alcoholic Liver Diseases; Alcohols; Aldehydes; Animals; Area; Bacterial Pneumonia; Basic Science; Biology; Brain; Categories; Cell model; Cigarette; Collaborations; Dedications; Development; Disease; Disease Progression; Environment; Environmental Exposure; Environmental Risk Factor; Etiology; Event; Exposure to; Faculty; Foundations; Functional disorder; Funding; Funding Opportunities; Future; Goals; Grant; Health; Heart Injuries; Hepatic; Hepatitis B Infection; Human; Immune; Immunity; Incidence; Individual; Infection; Institution; Interdisciplinary Study; Investigation; Knowledge; Liver; Lung; Marijuana Smoking; Medical center; Molecular; National Institute on Alcohol Abuse and Alcoholism; Natural Immunity; Nature; Nebraska; Nutritional; Nutritional status; Obesity; Occupational; Organ; Physiology; Pilot Projects; Predisposition; Research; Research Personnel; Research Project Grants; Resources; Role; Scientist; Services; Shapes; Signal Transduction; Structure; Talents; Tissue Model; Tobacco; Toxin; Trace metal; Training; Translating; Translational Research; United States; United States Department of Veterans Affairs; Universities; Work; Zinc deficiency; adduct; alcohol effect; alcohol misuse; alcohol research; animal tissue; cell injury; cigarette smoking; clinical translation; college; comorbidity; human tissue; insight; lifestyle factors; liver injury; member; metal metabolism; multidisciplinary; multiorgan damage; novel; pathogen; problem drinker; protein transport; recruit; symposium; tissue injury; training opportunity; Address; Age; Aging; Alcohol consumption; Alcoholic Fatty Liver; Alcoholic Liver Diseases; Alcohols; Aldehydes; Animals; Area; Bacterial Pneumonia; Basic Science; Biology; Brain; Categories; Cell model; Cigarette; Collaborations; Dedications; Development; Disease; Disease Progression; Environment; Environmental Exposure; Environmental Risk Factor; Etiology; Event; Exposure to; Faculty; Foundations; Functional disorder; Funding; Funding Opportunities; Future; Goals; Grant; Health; Heart Injuries; Hepatic; Hepatitis B Infection; Human; Immune; Immunity; Incidence; Individual; Infection; Institution; Interdisciplinary Study; Investigation; Knowledge; Liver; Lung; Marijuana Smoking; Medical center; Molecular; National Institute on Alcohol Abuse and Alcoholism; Natural Immunity; Nature; Nebraska; Nutritional; Nutritional status; Obesity; Occupational; Organ; Physiology; Pilot Projects; Predisposition; Research; Research Personnel; Research Project Grants; Resources; Role; Scientist; Services; Shapes; Signal Transduction; Structure; Talents; Tissue Model; Tobacco; Toxin; Trace metal; Training; Translating; Translational Research; United States; United States Department of Veterans Affairs; Universities; Work; Zinc deficiency; adduct; alcohol effect; alcohol misuse; alcohol research; animal tissue; cell injury; cigarette smoking; clinical translation; college; comorbidity; human tissue; insight; lifestyle factors; liver injury; member; metal metabolism; multidisciplinary; multiorgan damage; novel; pathogen; problem drinker; protein transport; recruit; symposium; tissue injury; training opportunity

The goal of the Alcohol Center of Research-Nebraska (ACORN) is to expand existing strengths and expertise in Nebraska to develop a novel niche in alcohol research, by creating a Center focused on the Alcohol Exposome. Alcohol research has been a major area of emphasis in Nebraska (at the Omaha VA Medical Center Research Service and at the University of Nebraska Medical Center) for over 5 decades. As a result, many contributions to the field of alcohol research and the treatment of alcoholic liver disease have been made. Studies examining the effects of alcohol on trace metal metabolism, lung biology and physiology, mechanisms of alcoholic fatty liver, role of aldehyde adducts in alcoholic cell injury, hepatic protein trafficking and signal transduction events and the role of immune mechanisms in alcoholic liver disease have been some of the key areas of investigation. Our goal is to translate to humans how factors in the exposome such as age, nutritional status, cigarette smoking, and exposure to pathogens interact in the presence or absence of alcohol administration. We know that a major component of the specific external environment is the lifestyle factor of alcohol consumption. Thus, under the comprehensive schema of the exposome, alcohol represents an environmental exposure that should be considered in context with other internal and external factors to understand causes and nature of disease progression. The overall hypothesis of our application is the following: the examination of alcohol in the context of the exposome will allow us to understand its role more fully in the etiology of disease and the subsequent manifestations of alcohol-induced human pathophysiology. The alcohol-exposome theme of the center is unique among alcohol centers and has the potential to be highly translational. Our investigators represent an outstanding team of interdisciplinary investigators that will be supported by an Administrative Core, a Biospecimen Core, and a Pilot Projects Core. ACORN investigators will have access to state-of-the art facilities at UNMC, Nebraska Medical Center and University of Nebraska-Lincoln. We include faculty from 5 departments and 3 colleges. Our proposed Specific Aims for the ACORN are to: 1) Facilitate interdisciplinary research and identify factors so that we can translate in humans how age, nutritional status, cigarette smoking, and exposure to pathogens interact in the presence or absence of alcohol administration. 2) Create a Biospecimen Core to aid Center investigators in promotion and development of translational animal and human tissue and cell models. 3) Enhance the collaborative ACORN environment and provide opportunities for funding through training, symposia, and pilot grants. Work on our 4 research projects, with participation of the Administration Core and the Biospecimen Core will allow us to realize our goals. Overall, this new P50 will utilize the expertise and knowledge of past research efforts to examine how alcohol, in the setting of various external and internal environmental factors will influence disease in a variety of organs and help us shape our future animal and human studies.

研究 - 内布拉斯加州（ACORN）酒精中心的目标是扩大现有的优势和专业知识 在内布拉斯加州，通过建立一个专注于酒精的中心来开发酒精研究中的新颖利基 展示体。酒精研究一直是内布拉斯加州重点的主要领域（在奥马哈VA医疗 中心研究服务和内布拉斯加州大学医学中心）已有50多年的历史了。因此， 对酒精研究领域和酒精性肝病治疗的许多贡献已经 制成。研究饮酒对痕量金属代谢，肺部生物学和生理学的影响， 酒精性脂肪肝的机制，醛加合物在酒精细胞损伤中的作用，肝蛋白运输 和信号转导事件以及免疫机制在酒精性肝病中的作用已经有些 调查的关键领域。我们的目标是将人类转化为诸如年龄之类的杂志中的因素如何 营养状况，吸烟和暴露于病原体的情况下在存在或不存在酒精的情况下相互作用 行政。我们知道，特定外部环境的主要组成部分是 饮酒。因此，在杂物体的全面模式下，酒精代表 环境暴露应与其他内部和外部因素进行考虑 了解疾病进展的原因和性质。我们应用的总体假设是 以下内容：在杂物体的背景下对酒精的检查将使我们能够理解其作用 在疾病的病因学和随后的酒精引起的人类的表现中更充分 病理生理学。该中心的酒精期主题在酒精中心是独一无二的，并且具有 潜力高度转化。我们的调查人员代表了一个杰出的跨学科团队 将由行政核心，生物镜核心和试点项目核心支持的调查人员。 橡子调查人员将可以在UNMC，内布拉斯加州医疗中心和 内布拉斯加州林肯大学。我们包括来自5个系和3所大学的教职员工。我们提出的具体 橡子的目的是：1）促进跨学科研究并确定因素，以便我们可以翻译 在人类中，年龄，营养状况，吸烟和暴露于病原体的情况如何 或缺乏饮酒。 2）创建一个生物循环核心，以促进促进中心调查员 以及转化动物和人体组织和细胞模型的发展。 3）增强协作 橡子环境，通过培训，研讨会和试点赠款提供资金的机会。工作 在我们的四个研究项目中，随着行政核心和生物循环核心的参与，我们将使我们 实现我们的目标。总体而言，这个新的P50将利用过去研究工作的专业知识和知识 检查酒精如何在各种外部和内部环境因素的情况下如何影响疾病 在各种器官中，并帮助我们塑造未来的动物和人类研究。