Vanderbilt Clinical Oncology Research Career Development Program

范德比尔特临床肿瘤学研究职业发展计划

• 批准号: 7649460
• 负责人: Kenneth R Hande
• 金额: $ 56.96万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-21 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7649460
• 关键词: Adult; Area; Award; Cancer Center; Childhood; Clinical; Clinical Investigator; Clinical Oncology; Clinical Oncology Supplement (K12); Clinical Research; Clinical Trials; Clinical Trials Design; Communities; Diagnostic Procedure; Discipline; Ensure; Environment; Faculty; Goals; Grant; Health; Hematology; Interdisciplinary Study; Laboratory Research; Light; Malignant Neoplasms; Master of Science; Medical; Medical Oncology; Mentors; Operative Surgical Procedures; Pediatric Hematology/Oncology; Peer Review; Physicians; Positioning Attribute; Radiation Oncology; Recruitment Activity; Research; Research Project Grants; Research Support; SECTM1 gene; Scientist; Series; Surgical Oncology; Therapeutic Human Experimentation; Time; Training; Training Programs; anticancer research; base; care systems; career; cost; design; effective therapy; experience; lectures; novel; novel diagnostics; oncology; patient oriented; patient oriented research; patient safety; programs; quality assurance; success

DESCRIPTION (provided by applicant): This is the first competing continuation application for the Vanderbilt Clinical Oncology Research Career Development Program (VCORCDP). The goals and objectives of the program remain unchanged from our original proposal: to train physicians for careers in academic-oriented, clinical oncology therapeutic research. The VCORCDP was originally designed to include three oncology disciplines and recruited candidates from fourth and fifth year surgical residents and second and third year fellows in pediatric or medical oncology/hematology. Based in part to the great success of the K12 sponsored training program, and in light of the decision to submit a recent NCI training grant to support the Division of Hematology and Oncology junior-level fellows, we are requesting support to restructure and expand the K12 VCORCDP to include senior level fellows and/or junior faculty candidates from four existing Vanderbilt oncology disciplines: (1) Adult Hematology and Oncology, (2) General Surgery/Surgical Oncology, (3) Pediatric Hematology and Oncology, and (4) Radiation Oncology. Trainees will participate in a comprehensive, didactic lecture series which focuses on the important aspects of clinical research (20% time commitment). All trainees will also participate in a mentored, patient-oriented, hypothesis-driven clinical research project which exposes them to Vanderbilt's extensive multidisciplinary research community (80% time commitment). Trainees are supported for a minimum of two years and research projects involve multiple mentors with both clinical and laboratory research experiences. The proposed training program faculty consists of thirty-eight mentors who are experienced clinical investigators or basic scientists within the Vanderbilt-lngram Cancer Center. All of the proposed faculty mentors have peer-reviewed research support directly related to cancer as well as a proven track record in mentoring fellows and junior faculty in an academic environment. Trainees successfully completing the two-year didactic lectures and patient-oriented research will be awarded a Master of Science in Clinical Investigation degree fromj Vanderbilt. Support is being requested for three training positions per year. The health and medical care system is creating an environment that places greater priority and demand on well-designed clinical trials. Cost-effective therapies, novel treatments and new diagnostic procedures need to be evaluated while ensuring patient safety and quality assurance. However, there are a number of obstacles limiting our ability to succeed in this area including a significant national concern regarding the shortage of physicians who choose academic careers in clinical research. The Vanderbilt-lngram Cancer Center is in a strong position to provide a strong training experience within a rich research environment, both of which are critical factors in determining successful careers in cancer research.

描述（由申请人提供）：这是范德比尔特临床肿瘤学研究职业发展计划（VCORCDP）的第一个竞争性延续申请。该计划的目的和目标与我们最初的提议保持不变：培训医生从事学术导向的临床肿瘤治疗研究。 VCORCDP 最初旨在包括三个肿瘤学学科，并从第四年和第五年的外科住院医师以及儿科或内科肿瘤学/血液学的第二年和第三年的研究员中招募候选人。部分基于 K12 赞助的培训计划取得的巨大成功，并考虑到最近决定提交 NCI 培训补助金以支持血液学和肿瘤学部初级研究员，我们请求支持以重组和扩大 K12 VCORCDP 将包括来自范德比尔特现有四个肿瘤学学科的高级研究员和/或初级教员候选人：(1) 成人血液学和肿瘤学，(2) 普通外科/肿瘤外科， (3) 儿科血液学和肿瘤学，以及 (4) 放射肿瘤学。学员将参加全面的教学系列讲座，重点关注临床研究的重要方面（投入 20% 的时间）。所有学员还将参加一个有指导的、以患者为导向、以假设为驱动的临床研究项目，让他们接触范德比尔特广泛的多学科研究社区（80% 的时间投入）。学员获得至少两年的支持，研究项目涉及多名具有临床和实验室研究经验的导师。拟议的培训计划教师由 38 名导师组成，他们是范德比尔特-英格拉姆癌症中心内经验丰富的临床研究人员或基础科学家。所有拟议的教师导师都拥有与癌症直接相关的同行评审研究支持，以及在学术环境中指导研究员和初级教师的良好记录。成功完成两年教学讲座和以患者为导向的研究的学员将获得范德比尔特大学临床研究理学硕士学位。每年请求支持三个培训职位。健康和医疗保健系统正在创造一个环境，更加重视和要求精心设计的临床试验。需要评估具有成本效益的疗法、新颖的治疗方法和新的诊断程序，同时确保患者安全和质量保证。然而，有许多障碍限制了我们在这一领域取得成功的能力，包括全国范围内对选择临床研究学术职业的医生短缺的重大担忧。范德比尔特-英格拉姆癌症中心处于有利地位，可以在丰富的研究环境中提供强大的培训经验，这两者都是决定癌症研究职业成功的关键因素。