Molecular & Developmental Biology in Pediatric Research

分子

• 批准号: 7534059
• 负责人: FREDERICK J SUCHY
• 金额: $ 41.04万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7534059
• 关键词: Animals; Area; Arts; Award; Basic Science; Biochemistry; Biomedical Research; Biophysics; Cells; Child; Child health care; Childhood; Clinical; Credentialing; Development; Developmental Biology; Disease; Educational workshop; Faculty; Fetus; Funding; Gene Expression Profiling; Genes; Goals; Human Genetics; Image; Immunobiology; Individual; Institution; Internal Medicine; K-Series Research Career Programs; Knockout Mice; Laboratories; Mentors; Methodology; Molecular; NCI Scholars Program; Nature; Pediatric Research; Pediatrics; Pharmacology; Physiology; Production; Qualifying; Recruitment Activity; Research; Research Personnel; Resources; Scientist; Screening procedure; Site; Training; Transgenic Organisms; Underrepresented Minority; base; career; design; experience; flexibility; interest; laboratory facility; medical schools; mouse model; multidisciplinary; novel strategies; pediatric department; pediatrician; programs

The Child Health Research Career Development Award (CHRCDA) Program at the Mount Sinai School of Medicine is designed to provide mentored, intensive basic research experience for a period of 2-3 years necessary to prepare pediatricians for productive and independent careers in biomedical research and academic pediatrics. The theme of this proposal, "Molecular and Developmental Biology in Pediatrics," has unique relevance to the most common disorders seen in childhood. It encompasses normal developmental biology as well as adaptation of the fetus and child to insults occurring during ontogenesis. The multidisciplinary nature of the program - drawing from the experience of established scientists inthe Department of Pediatrics, Human Genetics, Internal Medicine, Molecular, Cellular and Developmental Biology, Immunobiology, Pharmacology and Biological Chemistry, and Physiology and Biophysics - has evolved from common interests, frequent interactions, past training of pediatric scientists, and several areas of ongoing collaborative research of the faculty. The program will provide rigorous and flexible basic research experience for young pediatric scientists through collegia! interaction with Center faculty, through startup funding as provided by new project development awards, and through the program's educational core. The selection of new project development scholars by the Program Executive Committee will be highly competitive and only those individuals with exceptional credentials or potential will be accepted by the program's Executive Committee. A novel strategy to recruit under-represented minorities to the program will be implemented. A career plan will be prepared for each scholar that will consider specific long and short- term research career goals and the competencies that will contribute to development as an independent investigator. The laboratories of the program's faculty in the Department of Pediatrics and in basic science departments will serve as sites for pediatric research faculty development. The CHRCDA program will utilize the Shared Core Laboratories at Mount Sinai School of Medicine such as state of the art methodology for cell and whole animal imaging, for production of transgenic and knockout mouse models, and for high- throughput gene screening and gene expression profiling. All CHRCDA scholars will participate in didactic sessions designed to enhance their mentored program. Regular research seminars and periodic laboratory workshops will also promote interactions among young investigators and program faculty. Overall, the program is enhanced by centralization of laboratory facilities and faculty, the existing interactions amongst research programs within the institution, the many core laboratory resources which are readily available to researchers, and the recruitment base of highly qualified applicants already attracted to the excellence of Mount Sinai's clinical departments and basic sciences.

西奈山学校的儿童健康研究职业发展奖（CHRCDA）计划 医学旨在提供2 - 3年的指导，密集的基础研究经验 为生物医学研究中的生产和独立职业准备儿科医生的必要条件 学术儿科。该提议的主题是“儿科中的分子和发育生物学”的主题 与童年时期最常见的疾病的独特相关性。它包括正常发展 生物学以及胎儿和儿童对个体发生过程中发生的侮辱。这 该计划的多学科性质 - 从既定科学家的经验中汲取 儿科，人类遗传学，内科，分子，细胞和发育部 生物学，免疫生物学，药理学和生物学以及生理学和生物物理学 - 从共同利益，频繁的相互作用，过去对小儿科学家的培训以及几个领域发展而来 对教师的持续合作研究。该计划将提供严格且灵活的基本 通过Collegia为年轻的儿科科学家提供研究经验！与中心教师的互动，通过 新项目开发奖提供的启动资金以及通过该计划的教育 核。计划执行委员会选择新项目开发学者将是高度的 竞争激烈，只有那些具有特殊证书或潜力的人才能接受 计划的执行委员会。招募该计划中代表性不足的少数群体的新型策略将 实施。将为每个学者准备一项职业计划，该计划将考虑特定的长期和短期 - 术语研究职业目标以及将有助于发展为独立发展的能力 研究者。该计划教师在儿科和基础科学系的实验室 部门将作为儿科研究教师发展的场所。 CHRCDA计划将使用 西奈山医学院的共享核心实验室，例如艺术方法论 细胞和整个动物成像，用于生产转基因和基因敲除小鼠模型，以及高 吞吐量基因筛选和基因表达分析。所有CHRCDA学者将参加教学 旨在增强其指导计划的会议。定期研究研讨会和定期实验室 讲习班还将促进年轻研究人员和计划教师之间的互动。总体而言， 实验室设施和教职员工的集中化增强了计划，这是现有的互动 机构内的研究计划，许多核心实验室资源很容易可用 研究人员以及高素质申请人的招聘基地已经吸引了卓越 西奈山的临床部门和基础科学。