Molecular & Developmental Biology in Pediatric Research

分子

• 批准号: 7224278
• 负责人: FREDERICK J SUCHY
• 金额: $ 41.04万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7224278
• 关键词: Animals; Area; Arts; Award; Basic Science; Biochemistry; Biomedical Research; Biophysics; Cells; Child; Child health care; Childhood; Clinical; Credentialing; Development; Developmental Biology; Disease; Educational workshop; Faculty; Fetus; Funding; Gene Expression Profiling; Genes; Goals; Human Genetics; Image; Immunobiology; Individual; Institution; Internal Medicine; K-Series Research Career Programs; Knock-out; Laboratories; Mentors; Methodology; Molecular; NCI Scholars Program; Nature; Pediatric Research; Pediatrics; Pharmacology; Physiology; Production; Qualifying; Recruitment Activity; Research; Research Personnel; Resources; Scientist; Screening procedure; Site; Training; Transgenic Organisms; Underrepresented Minority; base; career; design; experience; interest; laboratory facility; medical schools; mouse model; multidisciplinary; novel strategies; pediatric department; pediatrician; programs

DESCRIPTION (provided by applicant): The Child Health Research Career Development Award (CHRCDA) Program at the Mount Sinai School of Medicine is designed to provide mentored, intensive basic research experience for a period of 2-3 years necessary to prepare pediatricians for productive and independent careers in biomedical research and academic pediatrics. The theme of this proposal, "Molecular and Developmental Biology in Pediatrics," has unique relevance to the most common disorders seen in childhood. It encompasses normal developmental biology as well as adaptation of the fetus and child to insults occurring during ontogenesis. The multidisciplinary nature of the program - drawing from the experience of established scientists in the Department of Pediatrics, Human Genetics, Internal Medicine, Molecular, Cellular and Developmental Biology, Immunobiology, Pharmacology and Biological Chemistry, and Physiology and Biophysics - has evolved from common interests, frequent interactions, past training of pediatric scientists, and several areas of ongoing collaborative research of the faculty. The program will provide rigorous and flexible basic research experience for young pediatric scientists through collegial interaction with Center faculty, through startup funding as provided by new project development awards, and through the program's educational core. The selection of new project development scholars by the Program Executive Committee will be highly competitive and only those individuals with exceptional credentials or potential will be accepted by the program's Executive Committee. A novel strategy to recruit under-represented minorities to the program will be implemented. A career plan will be prepared for each scholar that will consider specific long and short-term research career goals and the competencies that will contribute to development as an independent investigator. The laboratories of the program's faculty in the Department of Pediatrics and in basic science departments will serve as sites for pediatric research faculty development. The CHRCDA program will utilize the Shared Core Laboratories at Mount Sinai School of Medicine such as state of the art methodology for cell and whole animal imaging, for production of transgenic and knockout mouse models, and for high throughput gene screening and gene expression profiling. All CHRCDA scholars will participate in didactic sessions designed to enhance their mentored program. Regular research seminars and periodic laboratory workshops will also promote interactions among young investigators and program faculty. Overall, the program is enhanced by centralization of laboratory facilities and faculty, the existing interactions amongst research programs within the institution, the many core laboratory resources which are readily available to researchers, and the recruitment base of highly qualified applicants already attracted to the excellence of Mount Sinai's clinical departments and basic sciences.

描述（由申请人提供）：西奈山医学院的儿童健康研究职业发展奖（CHRCDA）计划旨在提供2 - 3年的指导，密集的基础研究经验，以便为儿科医生为生物医学研究和学术儿科医生的生产和独立职业做准备。该提议的主题是“儿科中的分子和发育生物学”，与童年时期最常见的疾病具有独特的相关性。它涵盖了正常的发育生物学以及胎儿和儿童对异化过程中发生的侮辱的适应。该计划的多学科性质 - 从儿科，人类遗传学，内科医学，分子，细胞和发育生物学，免疫生物学，药理学，药理学和生物学以及生理学和生物物理学的经验中汲取的经验 - 从普通兴趣，频繁的相互作用，对培训科学家进行培训的经常相互作用，以及在培养的科学方面进行了培训。该计划将通过与中心教师的联盟互动，通过新项目开发奖提供的启动资金以及通过该计划的教育核心，为年轻的儿科科学家提供严格而灵活的基础研究经验。计划执行委员会选择新的项目开发学者将具有很高的竞争力，只有那些具有卓越证书或潜力的个人才能被该计划的执行委员会接受。将实施一种新的招募代表性不足的少数群体的策略。将为每个学者准备一个职业计划，该计划将考虑特定的长期和短期研究职业目标以及将有助于发展成为独立研究者的能力。该计划在儿科和基础科学部门的实验室将作为儿科研究教师发展的地点。 CHRCDA计划将利用西奈山医学院的共享核心实验室，例如用于细胞和整个动物成像的艺术方法，生产转基因和敲除小鼠模型，以及高吞吐量基因筛选和基因表达分析。所有CHRCDA学者将参加旨在增强其指导计划的教学会议。定期的研究研讨会和定期实验室研讨会也将促进年轻研究人员和计划教师之间的互动。总体而言，通过集中化实验室设施和教师的集中化，机构内研究计划之间的现有互动，研究人员容易获得的许多核心实验室资源以及已经吸引了西奈山临床部门和基本科学的卓越性，可以提高该计划。