Histories of Social Engagement and Cognitive Functioning

社会参与和认知功能的历史

• 批准号: 7653309
• 负责人: Teresa E SEEMAN
• 金额: $ 51.43万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7653309
• 关键词: Abuse Reporting; Address; Adult; Affect; Age; Attention; Biological; Biology; California; Cessation of life; Child; Childhood; Cognition; Cognitive; Cognitive aging; Conflict (Psychology); Coronary heart disease; Critiques; Data; Data Set; Databases; Dementia; Divorce; Elderly; Emotional; Etiology; Event; Exhibits; Faculty; Family; Fathers; Funding; Future; Goals; Grant; Health; Healthcare; Impaired cognition; Individual; Interdisciplinary Study; Intervention; Investigation; Knowledge; Lead; Life Cycle Stages; Light; Link; Measures; Mental Health; Occupations; Outcome; Parents; Participant; Pattern; Performance; Physiology; Population; Positioning Attribute; Published Comment; Recording of previous events; Relative (related person); Reporting; Research; Research Personnel; Risk; Risk Factors; Role; Sampling; Series; Siblings; Social support; Socioeconomic Status; Subgroup; Testing; Time; Twin Multiple Birth; Validity of Self Report; Variant; Wages; Woman; Work; affection; aged; cardiovascular risk factor; cognitive change; cognitive function; cohort; effective intervention; experience; health disparity; high risk; improved; innovation; member; men; mortality; novel; physical abuse; physical conditioning; public health research; relating to nervous system; response; sex; social; sound; success; therapy design; therapy development

In response to the request for a revised set of Specific Aims, we propose to address the first two aims outlined in our June 2008 submission for R01 AG 032271 ("Social Engagement Histories and Cognition"). These two aims can be completed in a 2-year period and would test significant hypotheses regarding the potentially.. important relationships between patterns of social engagement from childhood through later adulthood and · sUbsequentadultcognition. Results of the proposed analyses will provide needed information on whether and how social relationships influence adult cognition - information that is crucial to our ability to develop effective interventions to reduce risks to cognition. Availability of such interventions will only become more critical as the fraction of the US population aged 65 and older (Le., those at high risk for poor cognition and its associated health care and other financial burdens) continues to grow rapidly in coming decades. ' I n consideration for the wider goals of the ARRA, we also note that the proposed work would fund two positions - one each at UCLA and Brandeis - for data analysts. In each case, these are positions that will be terminated unless this funding is received due to lack of adequate alternative grant support. Funding from this application would also cover portions of salaries for investigators who, although already on faculty at UCLA, " 'are supported solely by research funds so that their positions must be terminated if insufficient funding is available to cover their time (Le., they are not supported by State of California funds). Results of the proposed work hold the potential to create further jobs to the extent that findings lead to further efforts to develop interventions - with both intervention development and subsequent implementation involving new job opportunities. The reviewers were satisfied with the way we had addressed the majority of prior comments. Below, we provide brief responses to the few remaining questions raised by reviewers. Overall, we were gratified that reviewers felt that we were "very responsive to prior critiques", including provision of information "persuasive that the cognitive assessment is a strong measure of cognition", and that ours was a "very strong and innovative resubmission". We were also pleased that reviewers felt our application was "highly innovative", "addresses a significant issue with an innovative and sound approach", "demonstrates how interdisciplinary studies can be integrated in novel and unique ways", and "generates a high degree of enthusiasm",

为了响应修订具体目标的要求，我们建议解决 2008 年 6 月提交的 R01 AG 032271 中概述的前两个目标（“社会参与历史和认知”）这两个目标可以在 2 年内完成。 - 年期间，并将测试关于从童年到成年后期的社会参与模式与随后的成人认知之间潜在的重要关系的重要假设。所提出的分析结果将提供所需的结果。关于社会关系是否以及如何影响成人认知的信息——对于我们制定有效干预措施以降低认知风险的能力至关重要的信息，随着美国 65 岁及以上人口的比例增加，此类干预措施的可用性只会变得更加重要（Le.考虑到 ARRA 的更广泛目标，我们还注意到拟议的工作将资助两个职位——加州大学洛杉矶分校各一个，布兰代斯 - 对于数据分析师来说，除非由于缺乏足够的替代拨款支持而收到这笔资金，否则这些职位都将被终止。加州大学洛杉矶分校，“仅由研究基金支持，因此，如果没有足够的资金来支付他们的时间，他们的职位必须被终止（即，他们不受加利福尼亚州资金的支持）。拟议工作的结果有可能创造更多就业机会，只要调查结果导致进一步制定干预措施的干预措施——干预措施的制定和随后的实施涉及新的就业机会。 审稿人对我们处理之前大部分评论的方式感到满意，下面，我们对审稿人提出的少数剩余问题进行了简要答复。总体而言，我们很高兴审稿人认为我们“对之前的批评做出了非常积极的回应”。包括提供“有说服力的认知评估是认知评估的强有力的衡量标准”的信息，并且我们的申请是“非常有力且创新的重新提交”，我们也很高兴审稿人认为我们的申请“具有高度创新性”，“解决了一个重大问题”。 ”以创新和合理的方法提出问题”，“展示了如何以新颖和独特的方式整合跨学科研究”，并“产生高度的热情”，