Mentoring the Next Generation of Geriatric Oncology and Supportive Care Researchers in Patient-Oriented Research to Improve the Care of Older Adults with Cancer

指导下一代老年肿瘤学和支持性护理研究人员进行以患者为导向的研究，以改善患有癌症的老年人的护理

• 批准号: 10807909
• 负责人: WILLIAM DALE
• 金额: $ 18.57万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10807909
• 关键词: Achievement; Address; Age; Aging; American; American Society of Clinical Oncology; Award; Cancer Center; Cancer Patient; Caring; Cessation of life; Cities; Communities; Country; Data; Data Reporting; Databases; Dedications; Development; Development Plans; Diagnosis; Disease; Doctor of Philosophy; Educational process of instructing; Elderly; Ensure; Equity; Faculty; Fostering; Foundations; Funding; Future; Geriatric Assessment; Geriatrics; Goals; Grant; Guidelines; Health; Incidence; Individual; Infrastructure; Inherited; Institute of Medicine (U.S.); Intervention; Intervention Trial; Latinx; Lead; Leadership; Learning Skill; Left; Malignant Neoplasms; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Mexico; Midcareer Investigator Award in Patient-Oriented Research; National Cancer Institute; National Institute on Aging; Oncology; Outcome; Patient-Centered Care; Patient-Focused Outcomes; Patients; Persons; Population; Provider; Publications; Publishing; Recommendation; Research; Research Personnel; Resources; Risk; Risk Factors; Scholarship; Secure; Site; Standardization; Supportive care; Surveys; Toxic effect; Toxicity due to chemotherapy; Training; United States National Institutes of Health; Update; Vision; Work; cancer therapy; career; career development; clinical implementation; clinical practice; community setting; driving force; evidence base; high risk; human old age (65+); improved; infrastructure development; innovation; meetings; member; mid-career faculty; multidisciplinary; next generation; older patient; patient navigation; patient oriented research; prevent; programs; scale up; skills; standard of care; treatment optimization

ABSTRACT I have two overall career goals, which directly align with the aims of this proposal: 1) to generate high quality patient- oriented research at the nexus of geriatric oncology and supportive care interventions, generating the critically needed evidence to inform and improve the care of older adults with cancer through the use of new infrastructure underlying the City of Hope’s Center for Cancer and Aging and the national Cancer and Aging Research Group (CARG), both of which I lead; and 2) to mentor the next generation of geriatric oncology and supportive care scholars and future leaders in patient-oriented research based on newly-created infrastructure to ensure a healthy cadre of well-trained researchers in aging and cancer poised to sustain the field. This is important because one in three Americans over the age of 60 will be diagnosed with cancer in their lifetime. From 2010 to 2030, cancer incidence is expected to rise 67% for individuals age ≥ 65, making cancer a disease of aging. Dr. Arti Hurria, my close colleague from whom I inherited this award, dedicated her career to developing and validating the CARG Geriatric Assessment (GA) and conducting evidence-based research showing the positive patient-centered outcomes of GA-guided care. I am carrying out her vision cut short with her death. Although GA is now considered the standard of care, only 20% of older patients with cancer receive a GA in the community setting. The goal of this K24 Renewal for the Midcareer Investigator Award in Patient-Oriented Research is to: 1) unite the fields of geriatrics, oncology, and supportive care by building and sustaining the infrastructure to provide equitable patient-centered care for an aging oncology population, and 2) mentor the next generation of geriatric oncology and supportive care investigators and future leaders using this infrastructure. There are three components proposed in this application. The first is a comprehensive mentoring program to foster the career development of trainees from diverse backgrounds by teaching patient-oriented research skills for geriatric oncology and supportive care. This includes the development of an individualized career development plan that will enable each mentee to learn the skills of patient-oriented research; 1:1 mentor-mentee meetings; and seminars and coursework to foster mentees’ career development. The second component is to leverage the recently received infrastructure grants (NIA R33 grant, Rising Tide Foundation GOTO Grant, PI: W. Dale) to support the conduct of patient-oriented research focused on improving the care of older adults with cancer. The third component is my own career development plan, which will include expanding recent interventional and implementation work’s impact by leveraging newly developed infrastructure, and expanding my skill set in national aging scholarship through 1:1 mentoring. The research, mentorship, and training proposed in this application address key priorities identified by the National Institute of Aging, National Cancer Institute, Institute of Medicine, and American Society of Clinical Oncology to improve the care of older adults with cancer.

抽象的 我有两个总体职业目标，这与本提案的目标直接一致：1）培养高质量的患者- 以老年肿瘤学和支持性护理干预之间的关系为导向的研究，产生了关键的 需要证据来通过使用新的基础设施来告知和改善患有癌症的老年人的护理 希望之城癌症与老龄化中心和国家癌症与老龄化研究小组的基础 (CARG)，这两个项目都是我领导的；2) 指导下一代老年肿瘤学和支持性护理学者 和基于新创建的基础设施的以患者为导向的研究的未来领导者，以确保健康的骨干队伍 训练有素的衰老和癌症研究人员准备维持这一领域，这一点很重要，因为三分之一的研究人员。 60岁以上的美国人一生中将被诊断出患有癌症 从2010年到2030年，癌症发病率是 我的亲密同事 Arti Hurria 博士预计，年龄 ≥ 65 岁的人的癌症发病率将上升 67%，这使得癌症成为一种衰老疾病。 我从她那里继承了这个奖项，她的职业生涯致力于开发和验证 CARG 老年评估 (GA) 并进行循证研究，显示 GA 指导的护理 I 具有以患者为中心的积极成果。 虽然 GA 现在被认为是护理标准，但只有 20% 的患者正在实现她的愿景。 老年癌症患者在社区环境中接受 GA 本次 K24 职业中期更新的目标。 以患者为导向的研究中的研究者奖旨在：1）联合老年病学、肿瘤学和支持性研究领域 通过建设和维持基础设施来为老龄化肿瘤学提供公平的以患者为中心的护理 人口，2) 指导下一代老年肿瘤学和支持性护理研究人员和未来 使用此基础设施的领导者在此应用程序中提出了三个组件。 全面的指导计划，以促进来自不同背景的学员的职业发展 教授以患者为中心的老年肿瘤学研究技能和支持性护理。 个性化的职业发展计划，使每位学员能够学习以患者为中心的技能 研究；一对一导师与学员会议；以及促进学员职业发展的研讨会和课程作业。 第二个部分是利用最近收到的基础设施拨款（NIA R33 拨款、涨潮基金会 GOTO Grant，PI：W. Dale）支持开展以患者为中心的研究，重点是改善老年人的护理 第三个组成部分是我自己的职业发展计划，其中包括扩大近期的发展。 通过利用新开发的基础设施并扩大我的干预实施和工作影响 通过 1:1 指导的国家老龄化奖学金中提出的研究、指导和培训技能。 该应用程序解决了国家老龄化研究所、国家癌症研究所确定的关键优先事项， 医学研究所和美国临床肿瘤学会将改善老年人的护理 癌症。

项目成果

Signal Variability and Cognitive Function in Older Long-Term Survivors of Breast Cancer with Exposure to Chemotherapy: A Prospective Longitudinal Resting-State fMRI Study.

• DOI: 10.3390/brainsci12101283
• 发表时间: 2022-09-23
• 期刊: BRAIN SCIENCES
• 影响因子: 3.3
• 作者: Chen, Bihong T.;Chen, Zikuan;Deng, Frank;Patel, Sunita K.;Sedrak, Mina S.;Root, James C.;Ahles, Tim A.;Razavi, Marianne;Kim, Heeyoung;Sun, Can-Lan;Dale, William
• 通讯作者: Dale, William

Improving Care for Spanish-Speaking Older Adults with Breast Cancer: Feasibility, Reliability, and Validity of a Self-Administered Spanish Language Geriatric Assessment.

• DOI: 10.3390/cancers13112685
• 发表时间: 2021-05-29
• 期刊: Cancers
• 影响因子: 5.2
• 作者: Soto-Perez-de-Celis E;Vazquez J;Kim H;Sun CL;Charles K;Celis A;Katheria V;Li D;Dale W;Sedrak MS
• 通讯作者: Sedrak MS

The epidemiology of social isolation and loneliness among older adults during the last years of life.

• DOI: 10.1111/jgs.17366
• 发表时间: 2021-11
• 期刊: Journal of the American Geriatrics Society
• 影响因子: 6.3
• 作者: Kotwal AA;Cenzer IS;Waite LJ;Covinsky KE;Perissinotto CM;Boscardin WJ;Hawkley LC;Dale W;Smith AK
• 通讯作者: Smith AK

Predictors of hospital readmission among older adults with cancer.

• DOI: 10.1016/j.jgo.2020.03.008
• 发表时间: 2020-09
• 期刊: Journal of geriatric oncology
• 影响因子: 3
• 作者: Burhenn P;Sun CL;Scher KS;Hsu J;Pandya P;Chui CY;Arsenyan A;Mitani D;Morrison R;Katheria V;Hurria A
• 通讯作者: Hurria A

Reply to S. Sommerlatte et al.

回复 S. Sommerlatte 等人。

• DOI: 10.1200/jco.21.01865
• 发表时间: 2021
• 期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• 作者: DuMontier,Clark;Loh,KahPoh;Soto-Perez-de-Celis,Enrique;Dale,William
• 通讯作者: Dale,William