Geriatric Oncology Research Infrastructure to Improve Clinical Care

改善临床护理的老年肿瘤学研究基础设施

• 批准号: 10667860
• 负责人: WILLIAM DALE
• 金额: $ 66.96万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667860
• 关键词: Acceleration; Achievement; Address; Advocacy; Advocate; Age; Aging; American Society of Clinical Oncology; Applications Grants; Area; Award; Cancer Research Infrastructure; Caregivers; Caring; Collaborations; Communication; Country; Data; Dedications; Development; Elderly; Equity; Fostering; Foundations; Geriatric Assessment; Goals; Grant; Guidelines; Infrastructure; Interdisciplinary Study; International; Intervention; Leadership; Malignant Neoplasms; Mentors; Mentorship; Methodology; Oncology; Population; Principal Investigator; Productivity; Publishing; Randomized, Controlled Trials; Research; Research Infrastructure; Research Personnel; Resources; Scholarship; Science; Site; Toxicity due to chemotherapy; Vision; anticancer research; career development; clinical care; clinical practice; design; equity, diversity, and inclusion; improved; infrastructure development; innovation; leadership development; member; next generation; novel; older patient; patient advocacy group; patient oriented; response; video chat; web site

ABSTRACT The overall goal of this five year R33 grant proposal, “Geriatric Oncology Research Infrastructure to Improve Clinical Care,” submitted on behalf of the Cancer and Aging Research Group (CARG; mycarg.org), is to further expand CARG’s national research infrastructure to support innovative investigators, leaders, and projects to answer significant interdisciplinary research questions at the aging and cancer interface. This proposal, in response to PAR 20-071, supports “advanced-stage development and utilization of novel research infrastructure to advance the science of aging in specific areas requiring interdisciplinary partnerships or collaborations.” Even after creating a robust aging and cancer research infrastructure over the last five years through the R21/33 mechanism, there remains substantial unmet need to expand this infrastructure to develop high-impact research at the aging and cancer interface. The overall goal remains to significantly and rapidly improve the lives of older adults with cancer through scholarship and leadership by expanding CARG’s impact. With the support of the R21/33 mechanism, the multiple Principal Investigators (MPI: Dale, Mohile, Hurria/Klepin) completed a coordinated, broad-based strategy to infuse aging principles into oncology research. Through the original grant’s Aims, CARG has become a recognized international leader for mentorship and scholarship in aging and cancer. CARG is a coalition of aging and cancer scholars dedicated to: 1) connecting interdisciplinary investigators together; 2) designing, implementing, and disseminating aging and cancer research; 3) mentoring new interdisciplinary investigators in the field; and 4) disseminating and advocating for equitable research and care for older adults. In exceeding the aims of the R21/R33 award, CARG successfully transitioned from infrastructure development (R21) to establishment (R33), centering around six Cores and a Leadership Team. This R33 renewal is sought to expand CARG’s impact through the following Aims: 1) Expand the reach of the infrastructure, using the Cores, to facilitate the design and rigor of CARG’s aging and cancer research; 2) Facilitate high-priority, impactful research at the interface of aging and cancer through pilot awards and the conduct of large, competitive multi-site studies; 3) Identify, cultivate, and mentor CARG investigators for leadership in aging and cancer research to develop the next generation of leaders in the field; 4) Build greater capacity for engagement with older patients with cancer and caregivers through CARG’s patient advocacy group (SCOREboard) to further grow patient-centered aging and cancer research; and 5) Develop and disseminate geriatric oncology-specific content including best clinical practices, research findings, and opportunities for collaboration and advocacy through a robust communication strategy. Ultimately, the proposed activities will substantially expand CARG’s infrastructure to advance high-impact research aimed at improving the care of older adults with cancer globally.

抽象的 这项五年 R33 拨款提案的总体目标是“改善老年肿瘤学研究基础设施” 代表癌症与衰老研究小组（CARG；mycarg.org）提交的《临床护理》旨在 进一步扩大 CARG 的国家研究基础设施，以支持创新的研究人员、领导者、 以及回答有关衰老和癌症的重要跨学科研究问题的项目 该提案响应 PAR 20-071，支持“高级阶段开发和利用”。 新颖的研究基础设施，在需要跨学科的特定领域推进老龄化科学 即使在建立了强大的老龄化和癌症研究基础设施之后 在过去五年中，通过 R21/33 机制，仍然存在大量未满足的需求 扩大这一基础设施，以在衰老和癌症相互作用方面开展高影响力的研究。 总体目标仍然是通过以下方式显着、快速地改善患有癌症的老年人的生活 在 R21/33 机制的支持下，通过扩大 CARG 的影响力来发挥学术和领导作用。 多名首席研究员（MPI：Dale、Mohile、Hurria/Klepin）完成了一项协调一致、基础广泛的研究 通过最初资助的目标，CARG 制定了将衰老原理融入肿瘤学研究的战略。 成为衰老和癌症领域公认的指导和学术领域的国际领导者。 老龄化和癌症学者联盟致力于：1）将跨学科研究人员联系在一起；2） 设计、实施和传播衰老和癌症研究；3) 指导新的跨学科研究； 该领域的研究人员；4) 传播和倡导对老年人的公平研究和护理。 为了超越 R21/R33 奖项的目标，CARG 成功从基础设施开发转型 （R21）到建立（R33），以六个核心和一个领导团队为中心。这次 R33 更新是。 寻求通过以下目标扩大 CARG 的影响： 1) 扩大基础设施的覆盖范围， 使用核心，促进 CARG 衰老和癌症研究的设计和严谨性 2) 促进高优先级、 通过试点奖励和开展大型竞争性研究，在衰老和癌症的界面上进行有影响力的研究 3) 识别、培养和指导 CARG 研究人员在衰老和癌症研究中发挥领导作用 培养该领域的下一代领导者；4）增强与老年患者接触的能力； 通过 CARG 的患者倡导小组 (SCOREboard) 与癌症和护理人员合作，进一步发展以患者为中心 衰老和癌症研究；5) 开发和传播老年肿瘤学特定内容，包括最佳内容 临床实践、研究结果以及通过强有力的合作和宣传的机会 最终，拟议的活动将大大扩展 CARG 的基础设施 旨在改善全球癌症老年人护理的高影响力研究。

项目成果

Risk Factors for Hospitalizations Among Older Adults with Gastrointestinal Cancers.

患有胃肠癌的老年人住院的危险因素。

• DOI: 10.1093/oncolo/oyab016
• 发表时间: 2022-02-03
• 期刊: The oncologist
• 作者: Li D;Sun CL;Allen R;Crook CJ;Levi A;Ballena R;Klepin HD;Elias R;Mohile SG;Tew WP;Owusu C;Muss HB;Lichtman SM;Gross CP;Chapman AE;Gajra A;Cohen HJ;Katheria V;Hurria A;Dale W
• 通讯作者: Dale W

Visitation policies at NCI-designated comprehensive cancer centers during the COVID-19 pandemic.

• DOI: 10.1007/s00520-021-06183-z
• 发表时间: 2021-09
• 期刊: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
• 作者: Yeh JC;Subbiah IM;Dhawan N;Thompson BW;Hildner Z;Jawed A;Prommer E;Sinclair CT
• 通讯作者: Sinclair CT

Improving personalized treatment decision-making for older adults with cancer: The necessity of eliciting patient preferences.

• DOI: 10.1016/j.jgo.2021.06.001
• 发表时间: 2022-01
• 期刊: Journal of geriatric oncology
• 影响因子: 3
• 作者: Richardson DR;Loh KP
• 通讯作者: Loh KP

Adaptation of Serious Illness Care Program to be delivered via telehealth for older patients with hematologic malignancy.

• DOI: 10.1182/bloodadvances.2022008996
• 发表时间: 2023-05-09
• 期刊: BLOOD ADVANCES
• 影响因子: 7.5
• 作者: LoCastro, Marissa;Sanapala, Chandrika;Mendler, Jason H.;Norton, Sally;Bernacki, Rachelle;Carroll, Thomas;Klepin, Heidi D.;Watson, Erin;Liesveld, Jane;Huselton, Eric;O'Dwyer, Kristen;Baran, Andrea;Flannery, Marie;Kluger, Benzi;Loh, Kah Poh
• 通讯作者: Loh, Kah Poh

Study design and methods for the using exercise to relieve joint pain and improve AI adherence in older breast cancer survivors (REJOIN) trial.

• DOI: 10.1016/j.jgo.2021.05.011
• 发表时间: 2021-09
• 期刊: Journal of geriatric oncology
• 影响因子: 3
• 作者: Bluethmann SM;Truica C;Klepin HD;Olsen N;Sciamanna C;Chinchilli VM;Schmitz KH
• 通讯作者: Schmitz KH