Geriatric Oncology Research Infrastructure to Improve Clinical Care

改善临床护理的老年肿瘤学研究基础设施

• 批准号: 10667860
• 负责人: WILLIAM DALE
• 金额: $ 66.96万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667860
• 关键词: Acceleration; Achievement; Address; Advocacy; Advocate; Age; Aging; American Society of Clinical Oncology; Applications Grants; Area; Award; Cancer Research Infrastructure; Caregivers; Caring; Collaborations; Communication; Country; Data; Dedications; Development; Elderly; Equity; Fostering; Foundations; Geriatric Assessment; Goals; Grant; Guidelines; Infrastructure; Interdisciplinary Study; International; Intervention; Leadership; Malignant Neoplasms; Mentors; Mentorship; Methodology; Oncology; Population; Principal Investigator; Productivity; Publishing; Randomized, Controlled Trials; Research; Research Infrastructure; Research Personnel; Resources; Scholarship; Science; Site; Toxicity due to chemotherapy; Vision; anticancer research; career development; clinical care; clinical practice; design; equity, diversity, and inclusion; improved; infrastructure development; innovation; leadership development; member; next generation; novel; older patient; patient advocacy group; patient oriented; response; video chat; web site; Acceleration; Achievement; Address; Advocacy; Advocate; Age; Aging; American Society of Clinical Oncology; Applications Grants; Area; Award; Cancer Research Infrastructure; Caregivers; Caring; Collaborations; Communication; Country; Data; Dedications; Development; Elderly; Equity; Fostering; Foundations; Geriatric Assessment; Goals; Grant; Guidelines; Infrastructure; Interdisciplinary Study; International; Intervention; Leadership; Malignant Neoplasms; Mentors; Mentorship; Methodology; Oncology; Population; Principal Investigator; Productivity; Publishing; Randomized, Controlled Trials; Research; Research Infrastructure; Research Personnel; Resources; Scholarship; Science; Site; Toxicity due to chemotherapy; Vision; anticancer research; career development; clinical care; clinical practice; design; equity, diversity, and inclusion; improved; infrastructure development; innovation; leadership development; member; next generation; novel; older patient; patient advocacy group; patient oriented; response; video chat; web site

ABSTRACT The overall goal of this five year R33 grant proposal, “Geriatric Oncology Research Infrastructure to Improve Clinical Care,” submitted on behalf of the Cancer and Aging Research Group (CARG; mycarg.org), is to further expand CARG’s national research infrastructure to support innovative investigators, leaders, and projects to answer significant interdisciplinary research questions at the aging and cancer interface. This proposal, in response to PAR 20-071, supports “advanced-stage development and utilization of novel research infrastructure to advance the science of aging in specific areas requiring interdisciplinary partnerships or collaborations.” Even after creating a robust aging and cancer research infrastructure over the last five years through the R21/33 mechanism, there remains substantial unmet need to expand this infrastructure to develop high-impact research at the aging and cancer interface. The overall goal remains to significantly and rapidly improve the lives of older adults with cancer through scholarship and leadership by expanding CARG’s impact. With the support of the R21/33 mechanism, the multiple Principal Investigators (MPI: Dale, Mohile, Hurria/Klepin) completed a coordinated, broad-based strategy to infuse aging principles into oncology research. Through the original grant’s Aims, CARG has become a recognized international leader for mentorship and scholarship in aging and cancer. CARG is a coalition of aging and cancer scholars dedicated to: 1) connecting interdisciplinary investigators together; 2) designing, implementing, and disseminating aging and cancer research; 3) mentoring new interdisciplinary investigators in the field; and 4) disseminating and advocating for equitable research and care for older adults. In exceeding the aims of the R21/R33 award, CARG successfully transitioned from infrastructure development (R21) to establishment (R33), centering around six Cores and a Leadership Team. This R33 renewal is sought to expand CARG’s impact through the following Aims: 1) Expand the reach of the infrastructure, using the Cores, to facilitate the design and rigor of CARG’s aging and cancer research; 2) Facilitate high-priority, impactful research at the interface of aging and cancer through pilot awards and the conduct of large, competitive multi-site studies; 3) Identify, cultivate, and mentor CARG investigators for leadership in aging and cancer research to develop the next generation of leaders in the field; 4) Build greater capacity for engagement with older patients with cancer and caregivers through CARG’s patient advocacy group (SCOREboard) to further grow patient-centered aging and cancer research; and 5) Develop and disseminate geriatric oncology-specific content including best clinical practices, research findings, and opportunities for collaboration and advocacy through a robust communication strategy. Ultimately, the proposed activities will substantially expand CARG’s infrastructure to advance high-impact research aimed at improving the care of older adults with cancer globally.

抽象的 这五年R33赠款提案的总体目标是“老年肿瘤学研究基础设施 临床护理，代表癌症和衰老研究小组（carg; mycarg.org）提交的是 进一步扩大了卡格的国家研究基础设施，以支持创新的研究人员，领导者， 和项目以回答衰老和癌症的重大跨学科研究问题 界面。该提议响应第20-071套第20杆的响应，支持“先进的阶段开发和利用 新的研究基础设施，以推进需要跨学科的特定领域衰老科学 伙伴关系或合作。 在过去的五年中，通过R21/33机制，仍然没有必要 扩展这种基础设施以在衰老和癌症界面进行高影响研究。这 总体目标仍然可以通过 奖学金和领导力通过扩大卡格的影响。在R21/33机制的支持下 多个主要研究人员（MPI：戴尔，莫希尔，赫里亚/克莱平）完成了协调的，广泛的基础 将衰老原理注入肿瘤学研究的策略。通过原始赠款的目的，Carg有 成为公认的国际衰老和癌症心理和科学领导者。卡格是一个 衰老和癌症学者联盟致力于：1）将跨学科研究人员联系在一起； 2） 设计，实施和传播衰老和癌症研究； 3）心理新的跨学科 该领域的调查人员； 4）为老年人提供公平研究和护理。 在超过R21/R33奖的目标时，Carg成功地从基础设施开发过渡 （R21）建立（R33），以六个核心和一个领导团队为中心。此R33更新是 试图通过以下目的扩大Carg的影响：1）扩大基础设施的影响范围， 利用核心，促进卡尔格衰老和癌症研究的设计和严格； 2）促进高优先级， 通过试点奖和大型，竞争激烈的行为，在衰老和癌症界面的有影响力的研究 多站点研究； 3）识别，培养和心理CARG研究人员的衰老和癌症研究领导 发展该领域的下一代领导者； 4）建立更大的能力与老年患者互动 通过Carg的患者倡导小组（记分牌）与癌症和护理人员一起进一步发展以患者为中心 衰老和癌症研究； 5）开发和传播老年肿瘤学特定内容，包括最佳 通过强大的临床实践，研究结果以及协作和倡导的机会 沟通策略。最终，拟议的活动将大大扩展Carg的基础设施 提前的高影响力研究旨在改善全球癌症老年人的护理。