Bioresorbable Zinc Staples for Anastomoses in the Digestive Tract

用于消化道吻合术的生物可吸收锌钉

基本信息

批准号：
10809825
负责人：
Yi-Xian Qin
金额：
$ 39.54万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-03 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10809825
关键词：
Alloys Anastomosis - action Animal Model Anti-Bacterial Agents Behavior Biocompatible Materials Biodegradation Blood Vessels Blood specimen Body Fluids Cell model Cells Characteristics Child Chronic Clinical Corrosion Edema Elasticity Elements Epithelial Cells Excision Extravasation Fatigue Fibroblasts Foreign Bodies Fracture Gastric Juice Gastrointestinal Surgical Procedures Gastrointestinal tract structure Generations Goals Growth Hand Hardness Hemorrhage Home Image Immersion Implant Implantation procedure In Vitro Infection Inflammation Intestines Length of Stay Life Mechanics Metals Methods Microbe Miniature Swine Mucous body substance Natural regeneration Nature Operative Surgical Procedures Outcome Patients Phase Pilot Projects Polymers Procedures Property Provider Resistance Second Look Surgery Series Shapes Skin Tissue Specimen Speed Stomach Structure Surgical sutures Surgical wound Tensile Strength Testing Thick Thinness Time Tissue Adhesives Tissues Titanium Toxic effect Vacuum Veterinary Surgery Zinc antimicrobial biodegradable polymer biomaterial compatibility clinical practice design fabrication gastrointestinal grasp healing hemocompatibility implantation improved in vivo innovation intestinal juice mechanical properties melting metallicity natural antimicrobial operation recruit response restraint screening stem cell differentiation stem cells success systemic toxicity wound wound closure wound healing

Alloys Anastomosis - action Animal Model Anti-Bacterial Agents Behavior Biocompatible Materials Biodegradation Blood Vessels Blood specimen Body Fluids Cell model Cells Characteristics Child Chronic Clinical Corrosion Edema Elasticity Elements Epithelial Cells Excision Extravasation Fatigue Fibroblasts Foreign Bodies Fracture Gastric Juice Gastrointestinal Surgical Procedures Gastrointestinal tract structure Generations Goals Growth Hand Hardness Hemorrhage Home Image Immersion Implant Implantation procedure In Vitro Infection Inflammation Intestines Length of Stay Life Mechanics Metals Methods Microbe Miniature Swine Mucous body substance Natural regeneration Nature Operative Surgical Procedures Outcome Patients Phase Pilot Projects Polymers Procedures Property Provider Resistance Second Look Surgery Series Shapes Skin Tissue Specimen Speed Stomach Structure Surgical sutures Surgical wound Tensile Strength Testing Thick Thinness Time Tissue Adhesives Tissues Titanium Toxic effect Vacuum Veterinary Surgery Zinc antimicrobial biodegradable polymer biomaterial compatibility clinical practice design fabrication gastrointestinal grasp healing hemocompatibility implantation improved in vivo innovation intestinal juice mechanical properties melting metallicity natural antimicrobial operation recruit response restraint screening stem cell differentiation stem cells success systemic toxicity wound wound closure wound healing

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项目摘要

Summary: For anastomoses in the digestive tract, titanium (Ti) staples are most-commonly used because of good mechanical strength and ductility but are not biodegradable. Their life-time presence may interfere with imaging examinations and impede growth especially in young patients. The long-term existence would also increase the chance of clinical complications such as leakage, stricture, chronic inflammation, foreign body response, bleeding and infection. A second revision/removal surgery must be performed if the situation gets worse. Biodegradable polymer materials such as PLA-PGA based staples are available but largely for subcuticular applications. Their poor mechanical properties restrain their applications in gastrointestinal (GI) anastomoses which need high closure strength. Thus, these identified inadequacies in the properties of Ti and polymer staples open opportunities for bioresorbable metal (i.e., zinc) as a new generation of anastomotic staples for the digestive tract. The use of metallic Zn as an alternative bioresorbable staple could offer some distinct advantages. The higher strength of Zn makes it ideal for GI anastomoses while its bioresorbable nature may minimize the chance of anastomotic leakage and stricture and will not impede growth or cause chronic inflammation, bleeding and infection. Plus, Zn is an essential and natural element for life, its toxicity should be of minimal concern. In fact, evidence showed that Zn implants could promote stem cell recruiting and differentiation. Zn is also a natural antimicrobial biomaterial that can minimize potential infection after surgical wound-closure as GI mucus is home to trillions of microbes. Additionally, their degradation speed and mechanical strength can be further manipulated through alloying. The goal hereby is to develop bioresorbable Zn-based staples for anastomoses in the digestive tract and to validate their efficacy in cells and animal models through biodegradation, biocompatibility, antimicrobial testing, stem cell differentiation, as well as wound healing including the GI mucus barrier regeneration.

概括：对于消化道中的吻合，钛（Ti）主食是最常见的机械强度和延展性，但不可生物降解。他们的终身存在可能会干扰成像检查并阻碍增长，尤其是在年轻患者中。长期存在将还增加临床并发症的机会，例如泄漏，狭窄，慢性炎症，异物反应，出血和感染。必须进行第二次修订/删除手术如果情况恶化。可生物降解的聚合物材料，例如基于PLA-PGA的主食是可用，但主要用于下部应用。他们不良的机械性能约束需要高闭合强度的胃肠道（GI）吻合。因此，这些在Ti和聚合物主食的性能中确定了不足的生物可吸收机会金属（即锌）是新一代的消化道吻合式主食。金属的使用 Zn作为替代生物可吸收的主食可能会带来一些不同的优势。更高的强度 Zn使其非常适合胃肠道吻合，而其生物吸收性可能最小吻合式泄漏和狭窄，不会阻碍生长或引起慢性炎症，出血和感染。另外，Zn是生命的必不可少的自然元素，其毒性应该很小忧虑。实际上，有证据表明，锌植入物可以促进干细胞募集和分化。 Zn也是一种天然的抗菌生物材料，可以最大程度地减少潜在的感染手术伤口闭合是Gi Mucus，是数万亿微生物的家园。此外，它们的退化速度和机械强度可以通过合金来进一步操纵。特此目标是开发可生物可吸收的基于Zn的基准钉，以在消化道中吻合并验证其通过生物降解，生物相容性，抗菌测试，茎在细胞和动物模型中的功效细胞分化以及包括GI粘液屏障再生在内的伤口愈合。