Prioritizing diversity in polygenic risk prediction of primary open-angle glaucoma

原发性开角型青光眼多基因风险预测中优先考虑多样性

• 批准号: 10813253
• 负责人: Jessica N Cooke Bailey
• 金额: $ 13.87万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10813253
• 关键词: Acceleration; Administrative Supplement; Africa; African ancestry; Categories; Clinical Data; Data; Data Set; Doctor of Philosophy; Ensure; Exposure to; Eye; Funding; Genetic; Geography; Glaucoma; Goals; Grant; Individual; International; Lead; Meta-Analysis; Methods; Minority Groups; Nigeria; Parents; Primary Open Angle Glaucoma; Research; Risk; Sample Size; Site; Statistical Methods; Structure; United States National Institutes of Health; Universities; Work; genome wide association study; genome-wide analysis; member; parent grant; risk prediction; statistics; time use

Abstract This administrative supplement will facilitate completion of the specific aims of the parent grant, R01EY033829 Prioritizing Diversity in Polygenic Risk for Primary Open-Angle Glaucoma, in several ways. The parent grant structure is a consortium of research groups, each of whom have genome-wide association (GWAS) data from individuals of global African ancestry with ocular data evaluated by experts and categorized as glaucoma cases or controls. Each contributing member of the consortium will conduct analyses on their own data and submit summary statistics for meta-analysis to the PI, Dr. Jessica Cooke Bailey, and her group at Case Western Reserve University (CWRU). One key contributing member of the consortium is the Eyes of Africa group, based in Ibadan, Nigeria. This group has collected GWAS and clinical data from more than 6500 individuals with continental African ancestry, comprising an especially powerful dataset due to geographic ancestry and sample size. This administrative supplement will enable the Eyes of Africa statistician, Dr. Onoja Akpa, PhD, to work alongside the team of Dr. Cooke Bailey, an international leader in the field of glaucoma genetics, to complete analyses described in the specific aims of the parent R01. This will be accomplished via Dr. Akpa’s exposure to and real-time use of the most up-to-date methods for statistical analysis of GWAS data. This supplement will not only ensure the efficient completion of the proposed parent grant aims, but will also greatly enhance Dr. Akpa’s ability to conduct further analyses for the parent grant once he returns to the University of Ibadan. It will also serve to enhance the involvement of minority individuals in NIH-funded research.

抽象的 该行政补充将有助于完成母基金 R01EY033829 的具体目标 通过多种方式优先考虑原发性开角型青光眼的多基因风险的多样性。 结构是一个由研究小组组成的联盟，每个研究小组都拥有来自以下组织的全基因组关联（GWAS）数据： 全球非洲血统的个体，其眼部数据经过专家评估并归类为青光眼 联盟的每个贡献成员将对其自己的数据和控制进行分析。 向 PI、Jessica Cooke Bailey 博士和她在 Case 的团队提交汇总统计数据以进行荟萃分析 西储大学 (CWRU) 是该联盟的主要贡献成员之一。 总部位于尼日利亚伊巴丹的小组该小组收集了超过 6500 名患者的 GWAS 和临床数据。 具有非洲大陆血统的个体，由于地理原因组成了一个特别强大的数据集 该行政补充将使非洲之眼统计学家 Onoja 博士受益。 Akpa 博士将与青光眼领域国际领先者 Cooke Bailey 博士的团队合作 遗传学，以完成母体 R01 的具体目标中描述的分析。 Akpa 博士接触并实时使用最新的 GWAS 数据统计分析方法。 该补充不仅将确保有效完成拟议的家长补助金目标，而且还将 大大增强了 Akpa 博士返回母校后对家长补助金进行进一步分析的能力 伊巴丹大学还将有助于加强少数族裔个人对 NIH 资助的参与。 研究。