Culture-specific neurodevelopmental assessment of HIV-affected children: Home-Based Evaluation through Cloud-Readiness Enhancement

对受艾滋病毒影响的儿童进行特定文化的神经发育评估：通过云准备增强进行家庭评估

• 批准号: 10598698
• 负责人: Michael Joseph Boivin
• 金额: $ 43.22万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10598698
• 关键词: Administrative Supplement; Affect; Africa; African; Apache; Architecture; Attention; Award; Brain; COVID-19 outbreak; Child; Clinic; Clinical; Cloud Service; Communities; Computer software; Computers; Consult; Data; Development; Documentation; Environment; Evaluation; Goals; Grant; HIV; Home; Home environment; Internet; Intervention; Learning; Linux; Malawi; Nature; Network-based; Neurocognitive; Participant; Play; Provider; Readiness; Rehabilitation therapy; Research Personnel; Risk; School-Age Population; Schools; Short-Term Memory; Site; Source Code; Structure; Tablets; Technology; Testing; Time; Training; Uganda; United States National Institutes of Health; Width; Work; base; brain behavior; cloud based; cognitive testing; cognitive training; data sharing; executive function; health care settings; interoperability; low and middle-income countries; open source; pilot test; professor; scale up; software development; tool; usability

In R01HD098027 we have rolled out our Africa Brain Powered Games (BPG) tablet-based games app for use with HIV-affected children at our Kampala Uganda and Blantyre Malawi study clinic sites. BPG is a package of cognitive training games originally clinically tested (with NIH support) with HIV+ school children in Uganda. As a child plays, BPG gathers game data for neurocognitive assessment. During the lockdowns in 2020-2021 associated with COVID-19 outbreak in Uganda, we shifted BPG sessions from the clinic to the participant’s homes. Developing a cloud architecture would allow us to deliver content and receive data faster given the distributed nature of the cloud structure. If we could manage neurocognitive training app requests using the cloud-based integrated network of many servers, local mobile network bandwidth constraints in Africa could be circumvented. Real-time data requests could be scaled up to meet demand and therefore, not overwhelm a single local server. This is the overarching goal of making our computer-based assessment/rehabilitative apps with at-risk African children “cloud-ready” with the support of this supplemental grant. In Study Aim 1 we will evaluate concurrent and predictive validity of BPG and a newly developed prosocial game of reasoning and planning called Village Builder (VB) to other proven computer-based and testing battery indicators of brain/behavior integrity of neurocognitive function. Supplemental Development Activity for Study Aim 1. The software development activities most relevant to our 1st study aim is re-factoring software to scale efficiently to the cloud. Cloud-readiness consulting experts will work with R01 co-investigator and BPG and VB apps developer Professor Brian Winn to move the apps developed in his “serious games for entertainment and learning” (GEL) lab from the LAMP (Linux, Apache, MySQL, PHP) web stack to AWS or other cloud providers. We will then move our current PHP API used for internet-based data gathering to a REST API componentized application. Supplemental Development Activity for Study Aim 2 involves provisioning of standard source code structure, documentation, version management, build and test support in codebases that promotes community open-source enhancement. We will do so with such provisioning tools as Git/GitHub, that we have use for other software adaptations to the cloud. Prof. Winn’s GEL lab programmers will utilize JSON (JavaScript Object Notation). Most of the REST APIs and any native cloud services are going to utilize JSON as our R01 training/assessment apps (BPG and VB) are transitioned for cloud readiness in this supplemental software development initiative. Supplemental Development Activity for Study Aim 3 will pilot test the usability, interoperability and scalability of BPG under increasing internet real-time bandwidth at both sites (Uganda and Malawi). These include making use of enhanced hardware and clustering technology. Conclusion. This administrative supplement allows us to effectively interfacing the cloud to mobile-based internet real-time BPG and VB app management in the child’s home environment.

在R01HD098027中 在我们的坎帕拉乌干达（Kampala）和马拉维·马拉维（Blantyre Malawi）研究诊所的受艾滋病毒影响的儿童。 BPG是一个包裹 最初在乌干达与艾滋病毒+学童的认知培训游戏（在NIH支持下）。 小时候，BPG收集了游戏数据以进行神经认知评估。在2020-2021的锁定期间 与乌干达的Covid-19爆发有关，我们将BPG会议从诊所转移到了参与者的 房屋。开发云体系结构将使我们能够传递内容并更快地接收数据 云结构的分布性质。如果我们可以使用 许多服务器的基于云的集成网络，非洲本地移动网络带宽约束可以 被绕开。实时数据请求可以扩展以满足需求，因此，不是不知所措 一台本地服务器。这是进行基于计算机的评估/康复的总体目标 在这项补充赠款的支持下，拥有高危非洲儿童“准备云”的应用程序。在学习目标中1 我们将评估BPG的并发和预测有效性和新开发的亲社会游戏 推理和计划称为乡村建筑商（VB），以证明基于计算机和测试电池 神经认知功能的大脑/行为完整性的指标。补充发展活动 研究目的1。与我们的第一研究目标最相关的软件开发活动是重新输入软件 有效地扩展到云。云准备咨询专家将与R01共同研究员合作，并 BPG和VB应用程序开发人员Brian Winn教授将在他的“认真游戏中开发的应用程序 娱乐和学习”（凝胶）实验室（Linux，Apache，MySQL，PHP）网络堆栈到AWS或 其他云提供商。然后，我们将将当前用于基于Internet数据收集的当前PHP API移至 REST API组成应用程序。研究目标2的补充发展活动涉及 提供标准源代码结构，文档，版本管理，构建和测试支持 在促进社区开源增强的代码库中。我们将使用此类供应工具这样做 作为git/github，我们可以用于对云的其他软件改编。温恩教授的凝胶实验室 程序员将使用JSON（JavaScript对象符号）。大多数REST API和任何本地云 服务将使用JSON，因为我们的R01培训/评估应用程序（BPG和VB）已过渡 该补充软件开发计划中的云准备就绪。补充发展活动 对于学习目标3，将试用在互联网增加的互联网下测试BPG的可用性，互操作性和可伸缩性 两个地点的实时带宽（乌干达和马拉维）。这些包括利用增强的硬件和 聚类技术。结论。这种行政补充使我们能够有效地接口 在孩子家庭环境中，云到基于移动的Internet实时BPG和VB应用程序管理。