Integrated Public Health and Academic Collaboration for Infectious Diseases Control (iPHAC-IDC): Implementation of One Health approaches to pandemic preparedness and adolescent HIV prevention

传染病控制综合公共卫生和学术合作 (iPHAC-IDC)：实施“同一个健康”方法来预防大流行病和青少年艾滋病毒预防

• 批准号: 10807957
• 负责人: Supaporn Wacharapluesadee
• 金额: $ 40万
• 依托单位: CHULALONGKORN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2028-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10807957
• 关键词: Integrated; Public; Health; Academic; Collaboration

PROJECT SUMMARY/ABSTRACT Public health threats including emerging infectious diseases (EIDs) have highlighted the need for strengthening surveillance and laboratory systems for faster and smarter outbreak response. The Thai Department of Diseases Control (DDC), the Department of Medical Sciences (DMSc), Ministry of Public Health have collaboratively worked with Chulalongkorn University (CU) and the Thai Red Cross Society (TRC) on HIV research and other emerging endemic infectious disease surveillance, prevention, and control. This proposal will launch the “Integrated Public Health and Academic Collaboration for Infectious Diseases Control (iPHAC- IDC): Implementation of One Health approaches to pandemic preparedness and adolescent HIV prevention”, a collaborative nested network among infectious disease control researchers from DDC, DMSc, CU and TRC, as well as EID experts in the USA and France. The iPHAC-IDC will establish an integrated and sustainable network to prepare for future disease outbreaks in Thailand. We will conduct research to 1) Develop and implement the NextGen Public Health Surveillance Approaches by using the PCR, next-generation sequencing, and multiplex serology assays to identify novel viruses, characterize the genomes of new-rare viral strains of endemic diseases, EIDs, and AMR. These genomic data will be integrated with clinical and epidemiologic data to create a pathogen genomic surveillance platform. In addition, genomic-mathematic models will be developed and embedded in the platform for real-time analysis. One Health surveillance approaches in the environment, including wastewater and air, and SARS-CoV-2 reverse zoonoses in wildlife will be pursued. 2) Develop and implement the GLLP curriculum at the School of Global Health by creating a GLLP curriculum at the Faculty of Medicine, Chulalongkorn University, in two pattern courses; A mandatory course in the One Health Branch of the Medical Sciences program and an elective course for other graduate students and a lifelong learning platform for all participants with an option to keep the credits for further claims after enrollment to CU. 3) Develop a youth-focused HIV prevention service model in the government hospital network by establishing youth-focused clinics that provide comprehensive HIV education and prevention with pre-exposure prophylaxis leveraging social network strategies, and improving gonorrhea antimicrobial genomics resistance surveillance. This research will advance our understanding of the risk of EIDs and endemic diseases and strengthen in- country public health research capacity and promote laboratory workforce development for pandemic preparedness and adolescent HIV prevention.

项目概要/摘要 包括新发传染病 (EID) 在内的公共卫生威胁凸显了加强 泰国卫生部的监测和实验室系统，以实现更快、更智能的疫情应对。 疾病控制中心 (DDC)、医学科学司 (DMSc)、公共卫生部 与朱拉隆功大学 (CU) 和泰国红十字会 (TRC) 就艾滋病毒问题开展合作 研究和其他新发地方传染病的监测、预防和控制。 将启动“传染病控制综合公共卫生与学术合作”（iPHAC- IDC）：实施“同一个健康”方法来预防大流行病和预防青少年艾滋病毒”， 来自 DDC、DMSc、CU 和 TRC 的传染病控制研究人员之间的协作嵌套网络， 以及美国和法国的 EID 专家将建立一个综合的、可持续的。 网络，为泰国未来的疾病爆发做好准备。我们将进行研究：1) 开发和实施。 通过使用 PCR、下一代实施下一代公共卫生监测方法 测序和多重血清学测定来识别新病毒，表征新稀有病毒的基因组 地方病、EID 和 AMR 的病毒株这些基因组数据将与临床和耐药性相结合。 流行病学数据创建病原体基因组监测平台。 将开发模型并将其嵌入到 One Health 监测平台中。 环境中的方法，包括废水和空气，以及 SARS-CoV-2 逆转野生动物中的人畜共患病 2) 通过创建一个全球健康学院来开发和实施 GLLP 课程。 朱拉隆功大学医学院的 GLLP 课程，分为两门必修课程； 医学科学项目“一个健康分支”的课程和其他毕业生的选修课 学生和所有人的终身学习平台，可以选择保留学分以供进一步索赔 3) 在公立医院建立以青少年为中心的艾滋病预防服务模式。 通过建立以青年为中心的诊所，提供全面的艾滋病毒教育和预防，建立网络 利用社交网络策略进行暴露前预防，并改善淋病抗菌药物 基因组学耐药性监测。 这项研究将增进我们对 EID 和地方病风险的了解，并加强我们的研究。 国家公共卫生研究能力并促进大流行实验室劳动力发展 准备和青少年艾滋病毒预防。